San Francisco Giants vs St. Louis Cardinals Prediction 9/6/2025 Today’s MLB Picks

The San Francisco Giants and the St. Louis Cardinals meet Saturday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco Giants vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The San Francisco Giants will send out Justin Verlander for the start here and Verlander is 3-10 with a 4.29 ERA and 114 strikeouts this season. In his last five starts against St. Louis, Verlander is 3-1 with a 4.80 ERA and 19 strikeouts. Andre Pallante will get the start for the Cardinals here and is 6-13 with a 5.38 ERA and 101 strikeouts this season. In his career, Pallante is 1-0 with a 6.97 ERA and 9 strikeouts against the Giants.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to add on to their 8-2 win over the St. Louis Cardinals on Friday to sit at 72-69 this season. After this series, the Giants will go home to take on the Arizona Diamondbacks in a series.

Giants Win 5 In A Row And 10 Of Last 11

Jung Hoo Lee has 129 hits including a team-high 30 doubles along with 10 triples, 7 home runs and 48 RBIs with 10 stolen bases while Heliot Ramos has 143 hits with 23 doubles, 16 home runs and 59 RBIs. Wilmer Flores also 15 home runs and 67 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 89 hits with 20 home runs and 64 RBIs along with 17 doubles and Willy Adames has 118 hits with 18 doubles, 26 home runs and 76 RBIs of his own this season. 

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to bounce back from their loss at the hands of the Giants on Friday to fall to 70-72 this season. After this series, the Cardinals will head on the road for a series against the Seattle Mariners.

Cardinals Have Two-Game Win Streak Snapped

Brendan Donovan has a team-high 118 hits along with 25 doubles, 9 home runs and 45 RBIs while Lars Nootbaar has 106 hits with 13 home runs, 44 RBIs, 22 doubles and 4 stolen bases. Nolan Arenado also has 85 hits with 15 doubles, 10 home runs and 43 RBIs of his own and Victor Scott II has 79 hits with 14 doubles, a triple, 35 RBIs and a team-high 31 stolen bases. Willson Contreras has also chipped in 120 hits with 30 doubles, 20 home runs and 78 RBIs of his own as well this season. Masyn Winn’s added 122 hits with 27 doubles, 9 home runs and 51 RBIs and Alec Burleson’s added 123 hits with 21 doubles, 16 home runs and 60 RBIs.

San Francisco Giants @ St. Louis Cardinals Betting Trends: September 6, 2025

• Probable Starting Pitcher: Andre Pallante      Record this season: 6-13      ERA: 5.38
• Home Record: 4-6
• Last 5 against Giants: 1-0

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last five games as underdogs against National League opponents following a loss.
• The Giants have lost each of their last five games as favorites against the Cardinals following a road win.
• The Cardinals have covered the run line in each of their last six games as underdogs against the Giants.
• The Giants have failed to cover the run line in each of their last five games as favorites against the Cardinals following a road win.
• The Cardinals have led after 5 innings in six of their last eight games against the Giants.
• The Cardinals have led after 3 innings in three of their last four games as home underdogs against National League opponents.

• Probable Starting Pitcher: Justin Verlander      Record this season: 3-10      ERA: 4.29
• Road Record: 1-4
• Last 5 against Cardinals: 1-0

Why the San Francisco Giants will win

• The Giants have won each of their last nine games against National League opponents.
• The Cardinals have lost each of their last four home games against teams that held a winning record.
• The Giants have covered the run line in each of their last seven road games.
• The Cardinals have failed to cover the run line in each of their last six home games against NL West opponents.
• The Giants have led after 3 innings in each of their last six night games.
• The Giants have won the first inning in eight of their last nine games.
• The Giants have led after 5 innings in five of their last six night games.

Total Runs Facts

• Eight of the last nine games between the Giants and Cardinals have gone OVER the total runs line.
• Each of the Giants’ last five night games after playing the previous day have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Giants’ last nine games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the last nine games between the Giants and Cardinals.

St. Louis Cardinals Player Prop Facts

• Masyn Winn has recorded a Double in three of his four previous appearances against the Giants after playing the previous day.
• Willson Contreras has hit a home run in four of his last eight appearances in night games against NL West teams that held a winning record.
• Brendan Donovan has recorded at least one hit in each of his last nine appearances against the Giants.
• Victor Scott II ranks 10th in the league in Steals (31) this season.

San Francisco Giants Player Prop Facts

• Rafael Devers has hit a home run in each of his four previous road appearances against the Cardinals.
• Justin Verlander has recorded six or more strikeouts in four of his last five appearances against opponents that held a losing record.
• Dominic Smith has recorded at least one hit in each of his last 18 appearances in night games.
• Wilmer Flores has recorded a Double in four of his last five appearances at Busch Stadium.
• Rafael Devers ranks 8th amongst qualified players for On Base Percentage (.381) this season.

Matchup/League Facts

• The Cardinals rank T29th in the league for triples this season (7).
• The Cardinals rank 29th in the league for strikeouts this season (1050).
• The Giants rank 1st in the league for home runs allowed this season (123).
• The Giants rank 29th in the league for steals this season (63).

San Francisco Giants vs. St. Louis Cardinals Prediction

I’m backing the Giants here. I just like the form that the Giants are in right now, and St. Louis just can’t get out of their own way. It’s never easy to back Justin Verlander in his form for much of the year, where the Giants have had a hard time winning his starts, but they’re playing too well for me to go against right now so give me San Fran in this one.