San Francisco Giants vs St. Louis Cardinals Prediction 9/14/2026 Today’s MLB Picks

The San Francisco Giants and St. Louis Cardinals meet Monday in MLB action at Busch Stadium. Here’s a San Francisco Giants vs. St. Louis Cardinals Prediction. This article will include a San Francisco Giants vs. St. Louis Cardinals Pick.

San Francisco Giants Betting Preview

The San Francisco Giants are 62-88 on the year and play the Twins and Dodgers next. The San Francisco Giants are batting .247 on the season, have a .308 OBP, and have a .407 slugging percentage. The San Francisco Giants’ pitching staff has a 4.38 ERA and a 1.36 WHIP. Rafael Devers leads the San Francisco Giants with 144 hits and 98 RBI, while Jung Hoo Lee and Willy Adames have combined for 250 hits and 106 RBI.

Landen Roupp gets the ball for the San Francisco Giants, and he is 9-13 with a 4.00 ERA and 139 strikeouts this season. Roupp is 1-1 with a 5.59 ERA and 6 strikeouts in his career against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 74-76 this year and play the Nationals and Pirates next. The St. Louis Cardinals are batting .243 on the season, with a .317 OBP and a .385 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.29 ERA and a 1.35 WHIP. Alec Burleson leads the St. Louis Cardinals with 160 hits and 109 RBI, while Jordan Walker and Ivan Herrera have combined for 297 hits and 164 RBI.

Quinn Mathews gets the ball for the St. Louis Cardinals, and he is 1-3 with a 4.11 ERA and 28 strikeouts this season. This will be Mathews’ second career game against the San Francisco Giants.

Why the St. Louis Cardinals will win

• The Giants have lost 10 of their last 11 games against the Cardinals at Busch Stadium following a loss.
• The home team has won five of the Cardinals’ last six games.
• The Cardinals have covered the run line in seven of their last eight home games.
• The Giants have failed to cover the run line in eight of their last 10 games against the Cardinals following a loss.
• The Giants have trailed after 3 innings in three of their last four games as underdogs.
• The Cardinals have led after 5 innings in seven of their last nine games at Busch Stadium against NL West opponents that held a losing record.

Why the San Francisco Giants will win

• The Cardinals have lost seven of their last eight games as home favorites following a home win.
• The underdogs have won five of the last six games between the Giants and Cardinals.
• The Cardinals have failed to cover the run line in each of their last 14 games as home favorites against NL West opponents following a win.
• The Giants have covered the run line each of their last six night games against NL Central opponents that held a losing record.
• The Cardinals have trailed after 3 innings in three of their last four games against NL opponents.
• The Cardinals have trailed after 5 innings in each of their last three night games against opponents that held a losing record.
• The Giants have won the first inning in five of their last six games against NL opponents.

Total Runs Facts

• Each of the Giants’ last four games as underdogs have gone OVER the total runs line.
• Five of the Cardinals’ last six games as favorites have gone OVER the total runs line.
• There has been at least one run scored in the first inning in each of the Giants’ last 12 night games against NL opponents.
• There has been at least one run scored in the first inning in seven of the Cardinals’ last eight games against NL West opponents.

St. Louis Cardinals Player Prop Facts

• Ivan Herrera has hit a home run in five of the Cardinals’ last 12 games against NL West opponents that held a losing record.
• Nathan Church has recorded at least one hit in each of the Cardinals’ last 12 games.
• Jordan Walker ranks T9th in the league in Hits (159) this season.

San Francisco Giants Player Prop Facts

• Osleivis Basabe has hit a home run in four of his last seven appearances with the Giants as road underdogs against NL opponents.
• Bryce Eldridge has recorded at least one hit in 16 of his last 17 appearances in night games.

Matchup/League Facts

• The Cardinals rank 6th in the league for strikeouts against this season (1183).
• The Cardinals rank T24th in the league for triples this season (14).
• The Giants rank 27th in the league for on-base percentage this season (.308).
• The Giants rank 27th in the league for strikeouts this season (1121).

San Francisco Giants vs St. Louis Cardinals Prediction

I’m looking at the over in this spot. Roupp has a 4.00 ERA and 1.28 WHIP, and he has a 4.28 ERA and a .239 allowed batting average on the road. Mathews has a 4.11 ERA and 1.50 WHIP as he’s a rookie who is still trying to find his footing. He’s been better lately, but when he’s hit, he’s usually hit hard, and he still has issues with control. Mathews has walked 6 in his last 11 innings. Two pitchers who aren’t doing much for me these days. I expect some offense between two teams that have nothing to play for at this stage. Give me the over.

Randy Chambers's Pick: Over