San Francisco Giants vs San Diego Padres Prediction 4/29/25 MLB Picks

In this article, we will formulate a Giants vs Padres prediction for this MLB game on Tuesday, April 29, at PETCO Park in San Diego, California. Let’s take a look at the prediction for this MLB matchup.

San Francisco Giants Betting Preview

The San Francisco Giants (19-10, 10-6 Away) spent the previous two series at home, where they beat the Brewers and Rangers. After losing the opening game of the series against Texas, the Giants secured a pair of identical 3-2 wins. In the latest one, Heliot Ramos walked off the Rangers with a Little League homer, while Jordan Hicks pitched for 5.0 innings in a no-decision, allowing two runs on seven hits with three strikeouts and no walks. Camilo Doval was credited with the win.

This season, the Giants average 4.66 runs per game (9th in the MLB) on a .229/.311/.377 slash line. Regarding pitching, the Giants’ staff has a 3.40 ERA (7th) and 1.24 WHIP (13th). Wilmer Flores leads the Giants with a .248 batting average, seven home runs, and 28 RBI this season.

The projected starting pitcher for the Giants is Logan Webb, who is 3-1 in six starts this season, with a 1.98 ERA and 1.10 WHIP in 36.1 innings.

San Diego Padres Betting Preview

The San Diego Padres (17-11, 12-4 Home) are going through their worst stretch of the season. They lost seven of the previous nine games and are currently on a four-game losing skid, during which the Padres scored just three runs. San Diego also suffered the first sweep of the year, as they lost all three games to the Rays at home. In the most recent 4-2 defeat, Randy Vasquez took the loss after allowing three runs on five hits with one strikeout and two walks in 4.2 innings.

This year, the Padres average 3.79 runs per game (22nd in the MLB) on a .255/.324/.386 triple-slash. When it comes to pitching, the Padres’ staff has a 2.82 ERA (3rd) and 1.14 WHIP (6th). Fernando Tatis Jr. leads the Padres with a .346 batting average, eight home runs, and 18 RBI this season.

Nick Pivetta will take the mound for the Padres on Tuesday. The 32-year-old right-hander has a 4-1 record in five starts this year with a 1.20 ERA and 0.77 WHIP in 30.0 innings.

Total Runs Facts

• Seven of the Padres’ last eight home games have gone UNDER the total runs line.
• Each of the Giants’ last five road games against National League opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Padres’ last six games at Petco Park.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Giants’ last four night games.

Matchup/League Facts

• The Padres are one of only two teams in the league to rank top 10 in both strikeouts and on-base percentage this season.
• The Padres rank 2nd in the league for ERA this season (2.82).
• The Giants rank T6th in the league for strikeouts this season (259).
• The Giants rank T7th in the league for runs allowed this season (107).

Giants vs Padres Prediction

The Padres won six of the previous ten H2H encounters, including the last three. Seven of San Francisco’s last ten games went Under, which was the case in seven of San Diego’s previous ten games. Logan Webb vs. Nick Pivetta is a matchup favorable for the Under, and I expect to see a low-scoring affair. Pivetta allowed a .191 BA in 94 at-bats against the Giants, while Webb allowed a .120 BA in 75 at-bats against the Padres. This game has Under written all over it.

Oliver Zivic's Pick: Under 7.5