San Diego Padres vs San Francisco Giants Prediction 8/12/2025 Today’s MLB Picks

In this article, we will formulate a San Diego Padres vs San Francisco Giants Prediction for this MLB game on Tuesday, August 12th at the Oracle Park in the second game of this series, with the Padres having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

San Francisco Giants Preview

The San Francisco Giants have a 59-60 record this season and are sitting on the third place of the NL West. They have a 29-29 home record and are 54-60 in over/under. They are coming off a 1-4 home defeat by the Padres, and have three consecutive losses. Under is 4-0-1 in their last 5 games and are playing the Padres and the Rays next.

The Giants have a .233 batting average this season, .310 OBP and .375 Slugging percentage. San Francisco’s pitching staff has a 3.65 ERA and 1.28 WHIP. Heliot Ramos leads the Giants with 123 hits and is the team’s best hitter, with a .271 batting average. Willy Adames leads the team in RBI with 61, adding a team-high 18 home runs.

Robbie Ray (L) is the projected starting pitcher for the Giants, and he has a 9-5 record, 2.85 ERA and 1.13 WHIP.

San Diego Padres Preview

The San Diego Padres have a 67-52 record this season and are sitting on the second place of the NL West. They have a 29-32 road record, and are 50-66 in over/under. The Padres are coming off a 4-1 road victory over the Giants, and are 5-1 in their last 6 games. Over is 6-3 in their last 9 games and are playing the Dodgers and the Giants next.

The Padres have a .251 batting average this season, .321 OBP and .380 Slugging percentage. San Diego’s pitching staff has a 3.59 ERA and 1.21 WHIP. Manny Machado leads the Padres with 136 hits and team-high .297 batting average. He also leads the team in RBI, with 72, adding a team-high 20 home runs.

Nestor Cortes (L) is the projected starting pitcher for the Padres, and he has a 1-1 record, 7.11 ERA and 1.58 WHIP.

Why the San Francisco Giants will win

• The Padres have lost seven of their last nine games against NL West opponents following a win.
• The Giants have won three of their last four night games against NL West opponents.
• The Padres have failed to cover the run line in six of their last seven games against NL West opponents following a win.
• The Padres have lost the first inning in each of their last five road games against National League opponents that held a losing record.
• The Padres have trailed after 3 innings in four of their last five night games against NL West opponents that held a losing record.
• The Padres have trailed after 5 innings in each of their last six games against National League opponents that held a losing record.

Why the San Diego Padres will win

• The Giants have lost each of their last 11 home games after playing the previous day.
• The Padres have won each of their last four games as underdogs.
• The Padres have covered the run line in each of their last 14 games as underdogs against the Giants.
• The Giants have failed to cover the run line in each of their last 10 games as home favorites after playing the previous day.
• The Padres have won the first inning in four of their last five games at Oracle Park against National League opponents that held a losing record.
• The Padres have led after 3 innings in five of their last six games at Oracle Park against NL West opponents that held a losing record.
• The Padres have led after 5 innings in five of their last six games at Oracle Park against National League opponents that held a losing record.

Total Runs Facts

• Eleven of the Padres’ last 12 night games as underdogs have gone UNDER the total runs line.
• Eight of the Giants’ last nine games as favorites against the Padres have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Giants’ last eight games as home favorites against NL West opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Padres’ last four games as underdogs against NL West opponents.

Matchup/League Facts

• The Giants rank 1st in the league for home runs allowed this season (103).
• The Giants rank 29th in the league for steals this season (52).
• The Padres rank 1st in the league for hits allowed this season (885).
• The Padres rank 29th in the league for home runs this season (100).

San Diego Padres vs San Francisco Giants Prediction

The Padres are 8-2 in their last 10 meetings against the Giants, and are 5-2 in their 7 meetings this season. They are also 6-2 in their last 8 visits in San Francisco. Under is 4-1 in their last 5 meetings.

In this San Diego Padres vs San Francisco Giants Prediction, the Giants are coming as -125 road favorites. Padres have a better record and have been in far better form lately, but with Cortes on the mound, I’m bot rushing to back them up. Cortes has not yet find himself this season, and he is up against Robbie Ray, who has been dominating at home, with a 2.58 home ERA. The Padres are weaker against left-handed pitching, so this is the perfect opportunity for the hosts to bounce back. Take the San Francisco Giants on the moneyline at home in this one.