Aug 27, 2025; Seattle, Washington, USA; San Diego Padres designated hitter Ryan O'Hearn (32) is congratulated by catcher Freddy Fermin (54) during the sixth inning at T-Mobile Park. Mandatory Credit: Stephen Brashear-Imagn Images

San Diego Padres vs Minnesota Twins Prediction 8/29/2025 Today’s MLB Picks

Pick details

San Diego (75-59) vs Minnesota (60-73)

August 29, 2025 at 08:10 PM EDT

The Line: Betting Odds: Minnesota +1.5 — Over/Under: +8.5

(Get latest betting odds)

The San Diego Padres and Minnesota Twins meet Friday in MLB action at Target Field. Here’s a San Diego Padres vs Minnesota Twins Prediction. This article will include a San Diego Padres vs Minnesota Twins Pick.

San Diego Padres Betting Preview

The San Diego Padres are 75-59 on the year and play the Orioles, Rockies, and Reds next. The San Diego Padres are batting .251 on the season, have a .321 OBP, and a .385 slugging percentage. The San Diego Padres pitching staff has a 3.60 ERA and a 1.19 WHIP. Manny Machado leads the San Diego Padres with 149 hits and 78 RBI, while Luis Arraez and Fernando Tatis Jr. have combined for 279 hits and 103 RBI.

Nestor Cortes gets the ball for the San Diego Padres, and he is 2-2 with a 4.66 ERA and 25 strikeouts this season. Cortes is 2-2 with a 4.13 ERA and 28 strikeouts in his career against the Minnesota Twins.

Minnesota Twins Betting Preview

The Minnesota Twins are 60-73 on the year and play the White Sox, Royals, and Angels next. The Minnesota Twins are batting .238 on the season, have a .310 OBP, and a .398 slugging percentage. The Minnesota Twins pitching staff has a 4.44 ERA and a 1.31 WHIP. Byron Buxton leads the Minnesota Twins with 104 hits and 64 RBI while Trevor Larnach and Brooks Lee have combined for 200 hits and 107 RBI.

Zebby Matthews gets the ball for the Minnesota Twins, and he is 3-4 with a 5.30 ERA and 67 strikeouts this season. This will be Matthews’ second career game against the San Diego Padres.

San Diego Padres vs Minnesota Twins Prediction

Cortes has been decent since coming over from Milwaukee, allowing 17 hits and seven runs in his last 21 innings. Cortes has allowed seven runs in his last 27 innings overall. Cortes looks like a pitcher who has turned the corner. The Twins have been a mess all year and Matthews doesn’t provide much confidence, as he has a 5.30 ERA and 1.52 WHIP on the season. Matthews has allowed 15 runs in his last 23.2 innings. Matthews has a 4.42 ERA and .270 allowed batting average in 18.1 home innings. I’m rolling with the Padres and this new and improved Cortes.

Randy Chambers's Pick: San Diego Padres

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