Aug 16, 2025; Los Angeles, California, USA; Los Angeles Dodgers designated hitter Shohei Ohtani (17) reacts after a pitch during the first inning against the San Diego Padres at Dodger Stadium. Mandatory Credit: William Liang-Imagn Images

San Diego Padres vs Los Angeles Dodgers Prediction 8/17/2025 Today’s MLB Picks

Pick details

San Diego (69-54) vs Los Angeles (70-53)

August 17, 2025 at 04:10 PM EDT

The Line: Betting Odds: Los Angeles -145 — Over/Under: +8

(Get latest betting odds)

The San Diego Padres and the Los Angeles Dodgers meet Sunday in MLB action from Dodger Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Diego Padres vs. Los Angeles Dodgers prediction.

Starting Pitching Matchup

The San Diego Padres will send out Yu Darvish for the start here and is 2-3 with a 5.61 ERA and 29 strikeouts this season. In his last five starts against the Dodgers, Darvish is 2-0 with a 1.84 ERA and 22 strikeouts. Tyler Glasnow will get the nod for the Dodgers here and is 1-1 with a 3.08 ERA and 64 strikeouts this season. In his career, Glasnow is 0-0 with a 2.84 ERA and 21 strikeouts against the Padres.

San Diego Padres Recap

The San Diego Padres come into this game looking to rebound from a 6-0 loss at the hands of the Dodgers last time out to sit at 69-54 on the year. After this series, the Padres will head home for a series against the San Francisco Giants.

Padres Looking To Avoid Sweep

Manny Machado has 138 hits including a team-high 30 doubles, 20 home runs, 72 RBIs and 11 stolen bases while Fernando Tatis Jr. has 120 hits with 17 home runs and 49 RBIs along with 24 stolen bases of his own this season. Luis Arraez has added 136 hits with 23 doubles, 4 triples, 6 home runs and 46 RBIs while Jackson Merrill’s added 91 hits with 9 home runs and 51 RBIs as well. Xander Bogaerts also has 27 doubles and 19 stolen bases as well this season. Gavin Sheets also has 16 doubles, 15 home runs and 54 RBIs as well this season.

Why the San Diego Padres will win

  • The Dodgers have lost five of their last six games as home favorites against National League opponents following a win.
  • The Padres have won five of their last six games as underdogs after playing the previous day.
  • The Padres have covered the run line each of their last 10 day games against teams that held a winning record.
  • The Dodgers have failed to cover the run line in eight of their last nine day games against teams that held a winning record.

San Diego Padres Player Prop Facts

  • Manny Machado has hit at least one home run in four of his last 10 appearances in day games against NL West teams that held a winning record.
  • Jackson Merrill has recorded a Double in three of the Padres’ last four games as underdogs against NL West opponents.
  • Yu Darvish has recorded five or more strikeouts in 35 of his last 38 Sunday appearances in day games.
  • Gavin Sheets has recorded at least one hit in each of his last 11 appearances against NL West opponents that held a winning record.
  • Yu Darvish has recorded a win in six of his last eight appearances with the Padres as road underdogs.
  • Manny Machado ranks 3rd in the league in Hits (139) this season.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to build on their win over the Padres from Saturday to sit at 70-53 this season. After this series, the Dodgers will head on the road for a set at Coors Field against the Colorado Rockies.

Dodgers Win Back-To-Back Games

Shohei Ohtani has 132 hits including 16 doubles, 43 home runs, 80 RBIs and 8 triples while Tommy Edman has 69 hits with 12 home runs and 44 RBIs. Michael Conforto has 61 hits with 18 doubles while Teoscar Hernandez has 96 hits with 19 home runs, 23 doubles and 72 RBIs as well this season. Ohtani has a team-high 17 stolen bases while Max Muncy has 10 doubles but also has 71 strikeouts so far this season. Mookie Betts has also chipped in 12 home runs and 56 RBIs as well on the year. Freddie Freeman has also logged 122 hits with a team-high 29 doubles, 14 home runs and 66 RBIs. Andy Pages also has 122 hits with 20 doubles, 19 home runs and 69 RBIs as well this season.

Why the Los Angeles Dodgers will win

  • The Dodgers have won each of their last nine day games against NL West opponents.
  • The Padres have lost six of their last seven games at Dodger Stadium.
  • The Dodgers have covered the run line in each of their last five games as favorites against NL West opponents following a win.
  • The Padres have failed to cover the run line in four of their last five day games against the Dodgers at Dodger Stadium following a loss.

Los Angeles Dodgers Player Prop Facts

  • Teoscar Hernandez has hit at least one home run in three of the Dodgers’ last four games against NL opponents.
  • Tyler Glasnow has recorded six or more strikeouts in each of his last eight appearances at Dodger Stadium against opponents that held a winning record.
  • Teoscar Hernandez has recorded at least one hit in each of the Dodgers’ last nine games against NL West opponents.
  • Shohei Ohtani ranks T2nd in the league in Home Runs (43) this season.

Total Runs Facts

  • Each of the Padres’ last seven games as underdogs against NL West opponents have gone UNDER the total runs line.
  • Each of the Dodgers’ last six games as favorites against NL West opponents have gone UNDER the total runs line.

San Diego Padres vs. Los Angeles Dodgers Prediction

I’m on the Padres here. I get that the Dodgers have been the better team in this series, and Darvish historically can be a bit of a slow starter. However, I think that Glasnow is a bit overpriced and he’s a strikeout dependent starter that’s facing a Padres team that doesn’t strike out all that often. I think San Diego can ill afford to be swept here and I think the Padres salvage something. Give me the Padres in this one.

Chris Ruffolo's Pick: San Diego +125

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