Philadelphia Phillies vs Chicago Cubs Prediction 4/26/25 MLB Picks

In this article, we will formulate a Phillies vs Cubs prediction for this MLB game on Saturday, April 26, at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup.

Philadelphia Phillies Betting Preview

The Philadelphia Phillies (13-13, 4-9 Away) are experiencing their worst sequence of the year after losing five straight games. For the first time this season, the Phillies were swept in a series as the Mets beat them in three games, and then they opened this series in Chicago with a 4-0 defeat. Philadelphia failed to score for the second time this season. Taijuan Walker took the loss after allowing two runs on six hits with four strikeouts and two walks in 3.0 innings.

This year, the Phillies average 4.27 runs per game (15th in the MLB) on a .248/.337/.375 triple-slash. When it comes to pitching, the Phillies’ staff has a 4.33 ERA (23rd) and 1.35 WHIP (21st). Kyle Schwarber leads the Phillies with a .250 batting average, seven home runs, and 16 RBI this season.

Jesus Luzardo will take the mound for the Phillies on Saturday. The 27-year-old left-hander has a 2-0 record in five starts this year with a 2.08 ERA and 1.09 WHIP in 30.1 innings.

Chicago Cubs Betting Preview

The Chicago Cubs (17-10, 9-5 Home) defeated the Diamondbacks and swept the Dodgers in a two-game series to take the lead over the reigning champions in the season series with 4-3. The Cubs were rock-solid against the Phillies in Game 1 of the current series. Colin Rea got the win after allowing no runs on three hits with seven strikeouts and two walks over 5.0 innings of work.

This season, the Cubs average 6.19 runs per game (1st in the MLB) on a .267/.347/.461 slash line. Regarding pitching, the Cubs’ staff has a 4.13 ERA (18th) and 1.35 WHIP (22nd). Kyle Tucker leads the Cubs with a .308 batting average, seven home runs, and 25 RBI this season.

The projected starting pitcher for the Cubs is Ben Brown, who is 2-1 in four starts this season, with a 4.57 ERA and 1.75 WHIP in 21.2 innings.

Why the Phillies will beat the Cubs

• The Cubs have lost 12 of their last 13 games as underdogs against NL East opponents following a win.
• The Phillies have won five of their last six day games against NL Central opponents following a road loss.
• The Cubs have failed to cover the run line in six of their last seven games as underdogs against National League opponents following a win.
• The Phillies have covered the run line in four of their last five games as favorites against NL Central opponents following a road loss.

Total Runs Facts

• Each of the Phillies’ last six games as road favorites have gone UNDER the total runs line.
• Each of the Cubs’ last four day games against NL East opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Cubs’ last eight games as underdogs against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Phillies’ last seven games as road favorites against NL Central opponents.

Matchup/League Facts

• The Cubs rank 1st in the league for doubles this season (55).
• The Cubs rank 1st in the league for triples this season (8).
• The Phillies rank T3rd in the league for walks this season (112).
• The Phillies rank 28th in the league for opponent batting average this season (.261).

Phillies vs Cubs Prediction

The Phillies won seven of the previous ten H2H duels, but the Cubs were better in three of the last five. Even though the Phillies are going through their toughest patch of the season, I am backing them because of Luzardo, who has been impressive so far this year. Luzardo allowed more than two runs only once, while he allowed a .152 BA in 66 at-bats against the Cubs in his career. Ben Brown, on the other hand, posted two strong starts in a row, but the Phillies scored zero runs in Game 1, and I believe they will bounce back with 4+ runs in the opening five or six innings. Brown will be heavily tested in this one. I am backing the Phillies.