Minnesota Twins vs Houston Astros Prediction 6/29/2026 Today’s MLB Picks

The Minnesota Twins and the Houston Astros meet Saturday in MLB action from Target Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Minnesota Twins vs. Houston Astros prediction.

Starting Pitching Matchup

The Minnesota Twins will send out Zebby Matthews for the start here and Matthews is 3-5 with a 4.56 ERA and 39 strikeouts this season. Peter Lambert will start for the Astros this season and is 6-4 with a 3.28 ERA and 64 strikeouts this season.

Minnesota Twins Recap

The Minnesota Twins come into this game looking to add on to their 3-2 win over Colorado from Sunday’s matchup to sit at 40-45 this season. After this series, the Twins will head on the road for a series against the Yankees.

Twins Alternate Wins & Losses In 4 Straight

Byron Buxton has 81 hits with 15 doubles, a triple, 25 home runs and 43 RBIs while Josh Bell’s added 72 hits with 16 doubles, 9 home runs and 51 RBIs. Luke Keaschall has 67 hits with 12 doubles, 2 homers and 24 RBIs. Brooks Lee has 14 home runs with 47 RBIs and Victor Caratini has 31 RBIs while Kody Clemens has 61 hits with 16 doubles, 2 triples, 13 home runs and 34 RBIs this season.

Houston Astros Recap

The Houston Astros come into this game looking to add on to their 7-5 win over Detroit last time out to sit at 42-44 this season. After this series, the Astros will take on the Tampa Bay Rays in a series at home.

Astros Win 5 Of Last 6

Yordan Alvarez has 94 hits with 16 doubles, 25 home runs and 56 RBIs while Christian Walker has 76 hits with 16 doubles, 19 home runs and 56 RBIs on the year. Jose Altuve’s chipped in 57 hits with 12 doubles, 8 home runs and 21 RBIs and Isaac Paredes has 73 hits with 16 doubles, 11 home runs and 45 RBIs. Cam Smith also has 61 hits with 12 doubles, 9 home runs and 30 RBIs.

Minnesota Twins @ Houston Astros Betting Trends: June 29, 2026

• Probable Starting Pitcher: Peter Lambert      Record this season: 6-4      ERA: 3.28
• Home Record: 4-3
• Last 5 against Twins: –

Why the Houston Astros will win

• The Twins have lost each of their last four night games after playing the previous day.
• The Astros have won five of their last six games.
• The Twins have failed to cover the run line in six of their last seven games against the Astros following a win.
• The Astros have covered the run line in five of their last six games.
• The Twins have trailed after 3 innings in five of their last six games at Daikin Park against opponents that held a losing record.
• The Twins have trailed after 5 innings in four of their last five games at Daikin Park against opponents that held a losing record.

• Probable Starting Pitcher: Zebby Matthews      Record this season: 3-5      ERA: 4.56
• Road Record: 1-3
• Last 5 against Astros: 0-1

Why the Minnesota Twins will win

• The Astros have lost each of their last seven games as favorites after going to extra innings.
• The Twins have won four of their last five games as road underdogs.
• The Astros have failed to cover the run line in each of their last 12 games as favorites after going to extra innings.
• The Twins have covered the run line in 14 of their last 15 games as road underdogs against AL West opponents.
• The Twins have won the first inning in each of their last five road games against AL West opponents.
• The Twins have led after 3 innings in each of their last six road games against AL West opponents.
• The Twins have led after 5 innings in each of their last six games as underdogs against AL West opponents.

Total Runs Facts

• Seven of the Twins’ last eight games as underdogs against American League opponents have gone OVER the total runs line.
• Seven of the Astros’ last eight games after going to extra innings have gone OVER the total runs line.
• There has been at least one run scored in the first inning in each of the Twins’ last six road games against AL West opponents.
• There has been no run scored during the first inning in each of the Astros’ last four games.

Houston Astros Player Prop Facts

• Yordan Alvarez has hit at least one home run in three of his last five home appearances against the Twins.
• Peter Lambert has recorded a win in each of his last three home appearances.
• Isaac Paredes has recorded at least one hit in each of his last nine appearances with the Astros as home favorites against AL opponents.
• Yordan Alvarez ranks 1st amongst qualified players for Slugging Percentage (.613) this season.

Minnesota Twins Player Prop Facts

• Byron Buxton has hit at least one home run in 11 of his last 14 appearances in night games against AL teams that held a losing record.
• Zebby Matthews has recorded a win in three of his last four road appearances against AL West opponents.
• Zebby Matthews has recorded six or more strikeouts in six of his last eight appearances with the Twins as road underdogs.
• Trevor Larnach has recorded at least one hit in each of his last 15 appearances with the Twins as underdogs against AL West opponents.
• Byron Buxton ranks T2nd in the league in Home Runs (25) this season.

Matchup/League Facts

• The Astros rank 29th in the league for steals this season (28).
• The Astros rank 29th in the league for walks allowed this season (374).
• The Twins rank 28th in the league for ERA this season (4.86).
• The Twins rank 28th in the league for runs allowed this season (442).

Minnesota Twins vs. Houston Astros Prediction

I’m on the Astros in this one. Both teams have hit right-handed pitching well in June, but it’s the Astros that are just playing the better baseball right now and I think that Lambert is the better starter by a fair margin in this matchup. All in all, I look for the Astros to get the job done in this game.

Chris Ruffolo's Pick: Houston -125