Milwaukee Brewers vs Pittsburgh Pirates Prediction 9/16/2026 Today’s MLB Picks

In this article, we will formulate a Brewers vs Pirates Prediction for this MLB matchup on Wednesday, September 16th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Pittsburgh Pirates Preview

The Pittsburgh Pirates have a 75-76 record this season and are sitting in the 3rd place of the NL Central. They have a 38-35 home record and are coming off a 1-5 home loss against the Brewers. They will face the Royals and the Cardinals next.

The Pittsburgh Pirates have a .253 batting average this season, .330 OBP and .401 Slugging percentage. Pittsburgh’s pitching staff has a 4.18 ERA and 1.30 WHIP. Nick Gonzales is the team’s best hitter with a .307 batting average. Brandon Lowe leads the team in RBI with 86, adding a team-high 30 home runs.

Jared Jones (R) is the projected starting pitcher for the Pirates, and he has a 4-6 record, 4.10 ERA and 1.17 WHIP.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 94-57 record this season and are sitting in the 1st place of the NL Central. They have a 42-31 away record and are coming off a 5-1 road win against the Pirates. They will face the Orioles and the Phillies next.

The Milwaukee Brewers have a .259 batting average this season, .342 OBP and .406 Slugging percentage. Milwaukee’s pitching staff has a 3.56 ERA and 1.19 WHIP. Jackson Chourio is the team’s best hitter with a .289 batting average. Brice Turang leads the team in RBI with 92, while Jake Bauers adds a team-high 26 home runs.

Logan Henderson (R) is the projected starting pitcher for the Brewers, and he has a 10-3 record, 2.34 ERA and 0.78 WHIP.

Milwaukee Brewers @ Pittsburgh Pirates Betting Trends: September 16, 2026

• Probable Starting Pitcher: Jared Jones      Record this season: 4-6      ERA: 4.10
• Home Record: 1-3
• Last 5 against Brewers: 1-1

Why the Pittsburgh Pirates will win

• The Brewers have lost seven of their last eight night games against the Pirates following a road win.
• The Pirates have won each of their last five home games following a loss.
• The Pirates have covered the run line in each of their last nine Wednesday night games as home underdogs against NL opponents.
• The Brewers have failed to cover the run line in seven of their last eight games as road favorites against NL Central opponents following a win.
• The Pirates have led after 5 innings in three of their last four night games.

• Probable Starting Pitcher: Logan Henderson      Record this season: 10-3      ERA: 2.34
• Road Record: 4-3
• Last 5 against Pirates: 1-0

Why the Milwaukee Brewers will win

• The Brewers have won seven of their last eight night games against teams that held a losing record.
• The Pirates have lost seven of their last eight night games against NL Central opponents that held a winning record.
• The Brewers have covered the run line in each of their last nine games against the Pirates following a win.
• The Pirates have failed to cover the run line each of their last six home games against NL opponents that held a winning record.
• The Brewers have won the first inning in three of their last four games at PNC Park against opponents that held a losing record.
• The Pirates have trailed after 5 innings in each of their last seven games against NL Central opponents that held a winning record.
• The Brewers have led after 3 innings in seven of their last eight night games against opponents that held a losing record.

Total Runs Facts

• Each of the Brewers’ last seven games as favorites against the Pirates have gone UNDER the total runs line.
• Each of the Pirates’ last six night games against NL Central opponents have gone UNDER the total runs line.
• There has been no run scored during the first inning in each of Logan Henderson’s last eight road appearances as a starter.
• There has been no run scored during the first inning in each of the last seven night games between the Brewers and Pirates.

Pittsburgh Pirates Player Prop Facts

• Brandon Lowe has hit a home run in each of the Pirates’ last two games against the Brewers.
• Jared Jones has recorded six or more strikeouts in each of his last four appearances in night games.
• Ryan O’Hearn has recorded at least one hit in each of his last 13 appearances in night games against NL Central teams that held a winning record.
• Nick Gonzales ranks 4th amongst qualified players for Batting Average (.307) this season.

Milwaukee Brewers Player Prop Facts

• William Contreras has hit a home run in four of his last five appearances against opponents that held a losing record.
• Logan Henderson has recorded seven or more strikeouts in each of his last five appearances against opponents that held a losing record.
• Logan Henderson has recorded a win in each of his last four appearances against opponents that held a losing record.
• Andrew Vaughn has recorded at least one hit in each of his last nine appearances in night games against NL teams that held a losing record.
• Jake Bauers ranks 3rd amongst qualified players for On Base Percentage (.393) this season.

Matchup/League Facts

• The Pirates rank T2nd in the league for hits this season (1312).
• The Pirates rank 2nd in the league for home runs allowed this season (145).
• The Brewers rank 1st in the league for hits this season (1331).
• The Brewers rank 1st in the league for on-base percentage this season (.342).

Brewers vs Pirates Prediction

The Brewers have won their last four meetings against the Pirates but are 1-3 in their last four visits in Pittsburgh.

In this Brewers vs Pirates Prediction, the Brewers are coming as -135 road favorites. I like the Brewers in this one, as they have been red-hot lately with a 6-1 record in their last 7 games and have Logan Henderson on the mound, who has a 2.34 ERA and 0.78 WHIP this season and has been in excellent form. Jones has also been very good as of late, but the Pirates’ bats have been ice-cold lately and their bullpen has an almost 7 ERA in their last 5 games. Take the Brewers to win.

Nikos Lagouretos's Pick: Milwaukee Brewers ML