Los Angeles Dodgers vs San Francisco Giants Prediction 9/25/2026 Today’s MLB Picks

The Los Angeles Dodgers and the San Francisco Giants will meet Friday night in a National League West matchup at Oracle Park in San Francisco, California. Let’s take a look at this matchup from a betting perspective.

Los Angeles Dodgers Betting Preview

The Los Angeles Dodgers enter Friday’s contest with a 97-61 overall record (1st in the National League West) and a robust 46-32 mark on the road. Los Angeles arrives at this contest in below average form, losing the team’s last two games played this season, including a 5-1 loss to the San Diego Padres two days ago.

The Dodgers will turn to left hander Tarik Skubal in this game. In 25 starts made in 2026, Skubal has compiled an 11-7 win-loss record, a 2.85 ERA, a 0.99 WHIP and 176 strikeouts (22nd in MLB) in 151.2 innings pitched. Tarik Skubal has pitched well recently, allowing two earned runs or fewer in four of his last five starts made this season. Skubal will look to continue his recent dominant performances on the mound in tonight’s matchup with the Giants.

The Dodgers lineup features Shohei Ohtani and Freddie Freeman. Ohtani has tallied 30 home runs, 81 RBIs, a .278 batting average and a .903 OPS which ranks fourth in Major League Baseball. Freeman has compiled a .292 batting average, 16 home runs, 70 RBIs, 32 doubles and an .801 OPS.                                                                         

San Francisco Giants Betting Preview

The San Francisco Giants enter Friday’s contest with a 65-94 overall record (4th in the National League West) and a 37-41 mark at home. The Giants arrive at this contest in poor form, losing five of the team’s last six games, including a 3-2 loss to the Minnesota Twins.

The Giants will start right hander Yunior Marte in this contest. In four appearances made this season, Marte has compiled a 0-1 win-loss record, a 4.66 ERA, a 1.40 WHIP and 11 strikeouts in 19.1 innings pitched. Yunior Marte struggled in his most recent outing, allowing six earned runs while surrendering eight hits and three walks across 4.2 innings pitched in the Los Angeles Dodgers 10-4 defeat of the Giants last week.

Shifting our focus to the San Francisco offense, the Giants lineup features designated hitter Rafael Devers. Devers has compiled a team leading 37 home runs (6th in MLB), a .258 batting average, 36 doubles, 98 RBIs and an .865 OPS.                            

Why the Los Angeles Dodgers will win.

• Starting pitching. In 25 starts made in 2026, Tarik Skubal has compiled an 11-7 win-loss record, a 2.85 ERA, a 0.99 WHIP and 176 strikeouts in 151.2 innings pitched.

• Motivation. The Dodgers arrive at this contest on the heels of a two-game losing streak.

• Ability to win on the road. The Los Angeles Dodgers have amassed a 46-32 win-loss record away from home.

Why the San Francisco Giants will win.

• Starting pitching. In four appearances made this season, Yunior Marte has compiled a 4.66 ERA and a 1.40 WHIP in 19.1 innings pitched.

• Offensive production. Rafael Devers has amassed 37 home runs and 98 RBIs this season.

Los Angeles Dodgers vs. San Francisco Giants Prediction

In my opinion, this matchup favors the Los Angeles Dodgers. Why? Dodgers starting pitcher Tarik Skubal has been one of the best pitchers in Major League Baseball this season, compiling an 11-7 record with a 2.85 ERA, a 0.99 WHIP and 176 strikeouts. Additionally, Skubal has allowed two earned runs or fewer in four of his last five starts made in 2026. Conversely, Giants hurler Yunior Marte has been far more inconsistent, which is concerning when facing a formidable Dodgers lineup. With that said, I am backing the Los Angeles Dodgers to cover the 1.5 runs in this game.

Hans Geevers's Pick: Los Angeles Dodgers -1.5