Los Angeles Dodgers vs Arizona Diamondbacks Prediction 9/23/2025 Today’s MLB Picks

The Los Angeles Dodgers and the Arizona Diamondbacks meet Tuesday in MLB action from Chase Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Dodgers vs. Arizona Diamondbacks prediction.

Starting Pitching Matchup

The Los Angeles Dodgers will send out Shohei Ohtani for the start here and Ohtani is 1-1 with a 3.29 ERA and 54 strikeouts this season. This will be Ohtani’s second career start against Arizona. The Arizona Diamondbacks will send out Brandon Pfaadt for the start here and Pfaadt is 13-8 with a 5.02 ERA and 138 strikeouts this season. In his last five starts against the Dodgers, Pfaadt is 4-0 with a 3.81 ERA and 28 strikeouts.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to rebound from a 3-1 loss at the hands of the San Francisco Giants last time out to sit at 88-68 this season. After this series, the Dodgers will head on the road for a series against the Seattle Mariners.

Dodgers Have Four-Game Win Streak Snapped

Shohei Ohtani has 167 hits including 24 doubles, 53 home runs, 99 RBIs and 8 triples. Michael Conforto has 82 hits with 20 doubles while Teoscar Hernandez has 120 hits with 24 home runs, 28 doubles and 85 RBIs as well this season. Ohtani has a team-high 19 stolen bases while Max Muncy has 10 doubles but also has 73 strikeouts so far this season. Mookie Betts has also chipped in 20 home runs and 79 RBIs as well on the year. Freddie Freeman has also logged 158 hits with a team-high 39 doubles, 21 home runs and 85 RBIs. Andy Pages also has 155 hits with 27 doubles, 25 home runs and 82 RBIs as well this season.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to add on to their 9-2 win over the Philadelphia Phillies last time out to sit at 79-77 this season. After this series, the Diamondbacks will head on the road for a series against the San Diego Padres.

Diamondbacks Win 7 Of Their Last 10

Corbin Carroll has 143 hits with 31 home runs, 83 RBIs, 17 triples and 31 doubles this season. Carroll also has a team-high 30 stolen bases and Geraldo Perdomo has 26 stolen bases as well as 19 home runs and 97 RBIs with a team-high 166 hits this season. Ketel Marte’s added 26 home runs and 70 RBIs as well on the year and Lourdes Gurriel has 124 hits with 24 doubles, 19 home runs and 80 RBIs.

Los Angeles Dodgers @ Arizona Diamondbacks Betting Trends: September 23, 2025

• Probable Starting Pitcher: Brandon Pfaadt      Record this season: 13-8      ERA: 5.02
• Home Record: 9-3
• Last 5 against Dodgers: 4-0

Why the Arizona Diamondbacks will win

• The Diamondbacks have won each of their last five games as home underdogs.
• The Dodgers have lost four of their last five games as road favorites against National League opponents.
• The Diamondbacks have covered the run line in each of their last 12 games as underdogs following a win.
• The Dodgers have failed to cover the run line in each of their last eight games against the Diamondbacks following a home loss.
• The Dodgers have trailed after 3 innings in six of their last seven road games against National League opponents.
• The Diamondbacks have won the first inning in each of their last six games as home underdogs against National League opponents.
• The Diamondbacks have led after 5 innings in each of their last seven games as home underdogs against National League opponents.

• Probable Starting Pitcher: Shohei Ohtani      Record this season: 1-1      ERA: 3.29
• Road Record: 0-1
• Last 5 against Diamondbacks: 0-0

Why the Los Angeles Dodgers will win

• The Diamondbacks have lost seven of their last eight games against the Dodgers following a home win.
• The Dodgers have won seven of their last eight night games against NL West opponents.
• The Diamondbacks have failed to cover the run line in each of their last five home games against the Dodgers following a win.
• The Dodgers have covered the run line in each of their last four games as road favorites against the Diamondbacks following a loss.
• The Dodgers have led after 5 innings in eight of their last nine games against opponents that held a winning record.
• The Dodgers have led after 3 innings in three of their last four games as road favorites.

Total Runs Facts

• Four of the last five games between the Dodgers and Diamondbacks have gone UNDER the total runs line.
• Four of the Dodgers’ last five games as road favorites have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 16 of the Diamondbacks’ last 17 home games against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Dodgers’ last five night games against NL West opponents.

Arizona Diamondbacks Player Prop Facts

• Corbin Carroll has hit a home run in each of the Diamondbacks’ last two games against the Dodgers.
• Brandon Pfaadt has recorded six or more strikeouts in five of his last six appearances with the Diamondbacks as home underdogs.
• Geraldo Perdomo has recorded at least one hit in each of the Diamondbacks’ last 18 home games against NL opponents.
• Brandon Pfaadt has recorded a win in six of his last seven appearances with the Diamondbacks as home underdogs.
• Geraldo Perdomo has recorded a Double in each of the Diamondbacks’ last four night games.

Los Angeles Dodgers Player Prop Facts

• Freddie Freeman has hit at least one home run in four of the Dodgers’ last five games as road favorites against the Diamondbacks.
• Teoscar Hernandez has recorded a Double in each of his last three appearances with the Dodgers as road favorites against the Diamondbacks.
• Will Smith has recorded at least one hit in each of the Dodgers’ last 11 games as road favorites against the Diamondbacks.

Los Angeles Dodgers vs. Arizona Diamondbacks Prediction

I’m going to roll with Arizona here. It’s crazy to me to think that the Diamondbacks can get one past Shohei Ohtani, but Ohtani hasn’t always gone deep enough into games and for whatever reason, Pfaadt just keeps finding ways to succeed against the Dodgers. The Diamondbacks are a bit off the pace, but still have more to lose in this series. I think the Diamondbacks draw first blood here so give me Arizona in this one.