Houston Astros vs Baltimore Orioles Prediction 8/23/2025 Today’s MLB Picks

The Houston Astros and the Baltimore Orioles meet Saturday in MLB action from Camden Yards. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. Baltimore Orioles prediction.

Starting Pitching Matchup

The Houston Astros will start Cristian Javier and Javier is 1-1 with a 3.38 ERA and 7 strikeouts this season. In his career, Javier is 1-1 with a 1.89 ERA and 24 strikeouts against Baltimore. Dean Kremer will get the start for the Orioles and is 9-9 with a 3.97 ERA and 123 strikeouts this season. In his last five starts against Houston, Kremer is 4-0 with a 1.47 ERA and 26 strikeouts.

Houston Astros Recap

The Houston Astros come into this game looking to add on to their 10-7 win over the Orioles to sit at 71-58 this season. After this series, the Astros will head home for a series against the Colorado Rockies.

Astros Looking To Win Series

Jose Altuve has 132 hits including 19 doubles, 22 home runs and 64 RBIs. Jeremy Pena also has 119 hits with 22 doubles, 14 homers and 49 RBIs with 17 stolen bases as well. Jake Meyers has 15 doubles as well and Christian Walker has 18 home runs and 70 RBIs but has also accrued a team-high 137 strikeouts so far this season. Altuve also has 9 stolen bases while Jake Meyers has 14 stolen bases this season. Isaac Paredes also has 19 home runs with 50 RBIs of his own and Cam Smith has contributed 7 homers and 48 RBIs.

Why the Houston Astros will win

• The Astros have won eight of their last nine games as underdogs against the Orioles.
• The Orioles have lost four of their last five games as favorites.
• The Astros have covered the run line in each of their last 10 games as underdogs against AL East opponents following a road win.
• The Orioles have failed to cover the run line in each of their last five games as home favorites against AL West opponents.

Houston Astros Player Prop Facts

• Christian Walker has hit a home run in each of the Astros’ last three road games against opponents that held a losing record.
• Cristian Javier has recorded five or more strikeouts in 11 of his last 13 appearances in night games against AL teams that held a losing record.
• Cristian Javier has recorded a win in four of his last five appearances with the Astros as road underdogs against AL East opponents.
• Christian Walker has recorded at least one Double in three of the Astros’ last four games as underdogs against AL East opponents.
• Jake Meyers has recorded at least one hit in each of his last 16 road appearances against AL opponents.
• Jeremy Pena ranks 3rd amongst qualified players for Batting Average (.307) this season.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to rebound from their loss at the hands of the Astros on Friday to sit at 59-69 this season. After this series, the Orioles will take on the Boston Red Sox in a series at home.

Orioles Drop Back-To-Back Games

Adley Rutschman has 70 hits with 16 doubles, 9 homers and 29 RBIs. Jackson Holliday has 118 hits with 17 doubles, 2 triples, 15 homers and 49 RBIs. Gunnar Henderson has 128 hits with 29 doubles, 5 triples, 15 home runs and 57 RBIs with 16 stolen bases and 112 strikeouts while Holliday has a team-high 116 strikeouts as well this season. Heston Kjerstad’s added 4 homers and 19 RBIs while Jordan Westburg has 15 home runs and 34 RBIs this season.

Why the Baltimore Orioles will win

• The Astros have lost 10 of their last 12 games against American League opponents following a win.
• The Orioles have won six of their last eight games after playing the previous day.
• The Astros have failed to cover the run line in 17 of their last 19 games against American League opponents that held a losing record.
• The Orioles have covered the run line in seven of their last eight games after playing the previous day.

Baltimore Orioles Player Prop Facts

• Dean Kremer has recorded five or more strikeouts in each of his last seven appearances against opponents that held a winning record.
• Gunnar Henderson has recorded at least one hit in each of the Orioles’ last 11 home games.
• Dean Kremer has recorded a win in four of his five previous appearances against the Astros.
• Tyler O’Neill has hit a home run in four of his last five appearances with the Orioles as favorites.

Total Runs Facts

• Each of the Orioles’ last four games against AL West opponents have gone OVER the total runs line.
• Six of the Astros’ last seven games have gone OVER the total runs line.

Houston Astros vs. Baltimore Orioles Prediction

I’m going to side with Baltimore here. I’m still slightly concerned about Cristian Javier in a spot like this as he’s still working his way back from injury and while the Orioles did struggle in the first couple of games of this series, I think they can get on the board here. Kremer has been far more effective at home this season and also has great career numbers against the Astros. Give me Baltimore in this one.