Guardians vs Reds Prediction 7/29/2026 Today’s MLB Picks

In this article we will formulate a Guardians vs Reds prediction for this MLB game on Wednesday, July 29th at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 55-54 this season after they split the doubleheader on Tuesday by scores of 6-5 and 0-2. In game two, Cleveland allowed a run in the first inning and never found any offense in the loss. The Guardians recorded three hits and they were led by Hedges, who went 1-3 in the game. Williams allowed three hits and two earned runs over 7.0 innings for the loss, while Espino threw a scoreless inning in relief. Prior to this series, Cleveland lost all three against the Rays and split four games with the Twins. 

This season, Cleveland has a 3.75 ERA with a 1.26 WHIP and a .239 opponent batting average, while they have scored 426 runs with a .230 batting average and a .309 on base percentage. Chase DeLauter has led the Guardians with 11 home runs and 51 RBIs, while Angel Martinez has added 11 home runs and 33 RBIs. The projected starting pitcher for Cleveland is Joey Cantillo, who is 8-6 with a 4.02 ERA and a 1.46 WHIP over 109.2 innings pitched this season. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 50-56 this year after they won game two by a score of 2-0 on Tuesday night. Cincinnati scored once in the first inning and once in the fifth in the shutout win. The Reds recorded three hits in the game and they were led by Bleday, who went 1-3 with one home run and one RBI. Ferguson opened the game, while Franco got the win and Pagan picked up the save. Prior to this series, Cincinnati won two out of three against the Cardinals and two out of three against the Mariners. 

This season, Cincinnati has a 4.46 ERA with a 1.41 WHIP and a .245 opponent batting average, while they have scored 439 runs with a .230 batting average and a .308 on base percentage. Sal Stewart has led the Reds with 22 home runs and 79 RBIs, while Elly De La Cruz has added 18 home runs and 47 RBIs. The projected starting pitcher for Cincinnati is Brady Singer, who is 5-9 with a 4.53 ERA and a 1.38 WHIP over 103.1 innings pitched this year. 

Why the Cincinnati Reds will win

• The Reds have won each of their last six games as underdogs against the Guardians following a home win.
• The Guardians have lost four of their last five games as road favorites against NL Central opponents.
• The Reds have covered the run line in each of their last six games against the Guardians following a home win.
• The Guardians have failed to cover the run line in 20 of their last 24 games as favorites after playing the previous day.
• The Reds have led after 3 innings in three of their last four night games against AL Central opponents that held a winning record.
• The Reds have led after 5 innings in each of their last four night games against AL Central opponents that held a winning record.

Why the Cleveland Guardians will win

• The Reds have lost each of their last seven games at Great American Ball Park following a win.
• The Guardians have won five of their last six night games against National League opponents following a road loss.
• The Reds have failed to cover the run line each of their last seven Wednesday games against American League opponents that held a winning record.
• The Guardians have covered the run line in each of their last four games against the Reds following a loss.

Total Runs Facts

• Ten of the Guardians’ last 11 games as road favorites have gone UNDER the total runs line.
• Eight of the last nine games between the Guardians and Reds at Great American Ball Park have gone UNDER the total runs line.
• There has been no run scored during the first inning in seven of Brady Singer’s eight previous home appearances as a starter against the Guardians.
• There has been no run scored during the first inning in four of Joey Cantillo’s last five appearances as a starter.

Cincinnati Reds Player Prop Facts

• Brady Singer has recorded five or more strikeouts in each of his last nine appearances with the Reds as underdogs.
• Elly De La Cruz has recorded at least one hit in 10 of his last 11 appearances against AL Central opponents.
• Nathaniel Lowe has hit at least one home run in three of the Reds’ last four games as home underdogs against AL Central opponents.
• Brady Singer has recorded a win in three of his last four home appearances against AL Central opponents.

Cleveland Guardians Player Prop Facts

• Angel Martinez has hit a home run in each of his last two appearances with the Guardians as favorites against NL Central opponents.
• Joey Cantillo has recorded seven or more strikeouts in four of his last five appearances with the Guardians as favorites.
• Steven Kwan has recorded at least one hit in each of his last 10 Wednesday appearances against teams that held a losing record.

Guardians vs Reds Prediction 

Cincinnati split the doubleheader on Tuesday, but they have been red hot over the last two weeks. The Reds are 23-29 at home this year, while the Guardians are 28-28 on the road. Cleveland has lost four of their last five games and they have been shutout in three of their last four. The Guardians are starting Cantillo, who has allowed nine earned runs in his last 8.2 innings, while Singer has allowed two earned runs or fewer in three of his last four outings. Take the Reds here.

David Racey's Pick: Reds ML