May 22, 2026; Philadelphia, Pennsylvania, USA; Cleveland Guardians infielder Kyle Manzardo (9) rounds the bases after hitting a home run against the Philadelphia Phillies in the ninth inning at Citizens Bank Park. Mandatory Credit: Kyle Ross-Imagn Images
Kyle Ross-Imagn Images

Guardians vs Phillies Prediction 5/23/2026 Today’s MLB Picks

Pick details

MATCHUP Cleveland Guardians Philadelphia Phillies
Team Records 31-22 25-26
Where Citizens Bank Park, Philadelphia, Pennsylvania
When Saturday, May 23, 2026
Time 04:05 PM EDT
TV MLB.TV

In this article we will formulate a Guardians vs Phillies prediction for this MLB game on Saturday, May 23rd at Citizens Bank Park in Philadelphia, Pennsylvania. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 31-22 this year after they won game one by a score of 1-0 on Friday night. Cleveland had more than a few baserunners in this game, but they didn’t score until the ninth, which was enough for the win. The Guardians recorded six hits and they committed one error in the game, while they were led by Manzardo, who went 1-1 with one home run and one RBI. Williams allowed four hits and zero earned runs over 8.0 innings for the win, while Smith picked up the save. Prior to this series, Cleveland swept the Tigers in four games and won two out of three against the Reds. 

This season, Cleveland has a 3.60 ERA with a 1.24 WHIP and a .232 opponent batting average, while they have scored 229 runs with a .230 batting average and a .323 on base percentage. Chase DeLauter has led the Guardians with seven home runs and 30 RBIs, while Jose Ramirez has added eight home runs and 24 RBIs. The projected starting pitcher for Cleveland is Slade Cecconi, who is 3-4 with a 5.16 ERA and a 1.49 WHIP over 52.1 innings pitched this year. 

Philadelphia Phillies Betting Preview

The Philadelphia Phillies are 25-26 this season after they lost game one by a score of 1-0 last night. Philadelphia struggled at the plate all night and never got the offense going in the shutout loss. The Phillies recorded four hits in the game and they were led by Marsh, who went 1-3. Sanchez allowed four hits and zero earned runs over 8.0 innings, while Duran allowed one earned run for the loss. Prior to this series, Philadelphia lost two out of three against the Reds, but did sweep the Pirates in three games before that. 

This season, Philadelphia has a 4.24 ERA with a 1.35 WHIP and a .264 opponent batting average, while they have scored 209 runs with a .230 batting average and a .297 on base percentage. Kyle Schwarber has led the Phillies with 20 home runs and 36 RBIs, while Bryce Harper has added 12 home runs and 31 RBIs. The projected starting pitcher for Philadelphia is Zack Wheeler, who is 3-0 with a 1.99 ERA and a 0.88 WHIP over 31.2 innings pitched this season. 

Why the Philadelphia Phillies will win

  • The Phillies have won 10 of their last 11 games against American League opponents that held a winning record.
  • The Guardians have lost five of their last six road games against National League opponents following a win.
  • The Phillies have covered the run line in seven of their last eight home games against American League opponents that held a winning record.
  • The Guardians have failed to cover the run line in four of their last five road games against National League opponents following a win.
  • The Guardians have trailed after 5 innings in three of their last four road games against NL East opponents that held a losing record.

Why the Cleveland Guardians will win

  • The underdogs have won eight of the Guardians’ last nine games at Citizens Bank Park.
  • The Phillies have lost each of their last three games as home favorites.
  • The underdogs have covered the run line in eight of the Guardians’ last nine games at Citizens Bank Park.
  • The Phillies have failed to cover the run line in seven of their last eight home games following a home loss.
  • The Phillies have trailed after 3 innings in three of their last four day games against American League opponents that held a winning record.

Total Runs Facts

  • Each of the Guardians’ last four road games have gone UNDER the total runs line.
  • Each of the Phillies’ last four games against American League opponents have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Guardians’ last four games.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the last six games between the Guardians and Phillies.

Philadelphia Phillies Player Prop Facts

  • Kyle Schwarber has hit at least one home run in four of his last five home appearances.
  • Bryson Stott has recorded at least one hit in each of his last nine home appearances against opponents that held a winning record.
  • Zack Wheeler has recorded seven or more strikeouts in each of his last six appearances with the Phillies as favorites against AL Central opponents.

Cleveland Guardians Player Prop Facts

  • Rhys Hoskins has hit a home run in two of his last three appearances at Citizens Bank Park against NL opponents that held a losing record.
  • Steven Kwan has recorded at least one hit in each of his last 11 Saturday day appearances with the Guardians as underdogs.

Guardians vs Phillies Prediction 

Cleveland was able to extend their winning streak with a low scoring win on Friday night and they have allowed two runs or fewer in four of their last five games. The Guardians are 16-12 on the road this year, while the Phillies are 13-15 at home. Philadelphia has lost three in a row and they have scored one run or fewer in two of those three losses. The Phillies are starting Wheeler, who has allowed two earned runs or fewer in four of his last five starts, while Cecconi has allowed two earned runs or fewer in three straight. Take the under here.

David Racey's Pick: Under 7.5

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