Colorado Rockies vs Chicago White Sox Prediction 9/25/2026 Today’s MLB Picks

In this article, we will formulate a Rockies vs White Sox Prediction for this MLB matchup on Friday, September 25th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Chicago White Sox Preview

The Chicago White Sox have a 82-77 record this season and are sitting in the 2nd place of the AL Central. They have a 46-32 home record and are coming off a 1-9 road loss against the Royals.

The Chicago White Sox have a .236 batting average this season, .321 OBP and .404 Slugging percentage. Chicago’s pitching staff has a 4.13 ERA and 1.32 WHIP. Chase Meidroth is the team’s best hitter with a .275 batting average. Miguel Vargas leads the team in RBI with 92, adding a team-high 33 home runs.

Sean Burke (R) is the projected starting pitcher for the White Sox, and he has a 10-7 record, 3.40 ERA and 1.20 WHIP.

Colorado Rockies Preview

The Colorado Rockies have a 57-102 record this season and are sitting in the 5th place of the NL West. They have a 25-53 away record and are coming off an 8-12 home loss against the Diamondbacks.

The Colorado Rockies have a .254 batting average this season, .323 OBP and .417 Slugging percentage. Colorado’s pitching staff has a 5.59 ERA and 1.53 WHIP. TJ Rumfield is the team’s best hitter with a .297 batting average. Hunter Goodman leads the team in RBI with 84, adding a team-high 39 home runs.

Tomoyuki Sugano (R) is the projected starting pitcher for the Rockies, and he has a 12-11 record, 5.36 ERA and 1.33 WHIP.

Colorado Rockies @ the Chicago White Sox Betting Trends: September 25, 2026

• Probable Starting Pitcher: Sean Burke      Record this season: 10-7      ERA: 3.40
• Home Record: 3-5
• Last 5 against Rockies: –

Why the Chicago White Sox will win

• The Rockies have lost each of their last 10 road games.
• The White Sox have won each of their last five night games against NL West opponents that held a losing record.
• The Rockies have failed to cover the run line in each of their last six road games.
• The White Sox have covered the run line in each of their last four night games against NL West opponents.
• The Rockies have trailed after 5 innings in each of their last 14 night games against opponents that held a winning record.
• The Rockies have trailed after 3 innings in eight of their last nine games against opponents that held a winning record.
• The Rockies have lost the first inning in each of their last six night games.

• Probable Starting Pitcher: Tomoyuki Sugano      Record this season: 12-11      ERA: 5.36
• Road Record: 5-4
• Last 5 against White Sox: –

Why the Colorado Rockies will win

• The White Sox have lost each of their last eight games against NL opponents following a win.
• The road team has won seven of the Rockies’ last eight games.
• The White Sox have failed to cover the run line in each of their last 14 games as favorites following a road win.
• The underdogs have covered the run line in each of the last four games between the Rockies and White Sox.
• The White Sox have lost the first inning in three of their last four games against NL West opponents.
• The White Sox have trailed after 5 innings in seven of their last eight home games against NL opponents.
• The White Sox have trailed after 3 innings in each of their last four games against NL West opponents.

Total Runs Facts

• Each of the White Sox’s last four games have gone OVER the total runs line.
• Each of the Rockies’ last four night games as underdogs have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of the Rockies’ last seven night games.
• There has been at least one run scored in the first inning in each of the White Sox’s last five night games.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit a home run in six of the White Sox’s last seven Friday games as favorites.
• Sam Antonacci has recorded at least one hit in each of the White Sox’s last seven games against NL opponents that held a losing record.
• Sean Burke has recorded a win in three of his last four appearances.

Colorado Rockies Player Prop Facts

• Hunter Goodman has hit at least one home run in three of his last five road appearances against AL Central opponents.
• Tomoyuki Sugano has recorded four or more strikeouts in each of his last four road appearances.
• Connor Norby has recorded at least one hit in each of his last eight appearances with his team as an underdog against AL Central opponents.
• TJ Rumfield ranks 3rd amongst qualified players for On Base Percentage (.388) this season.

Matchup/League Facts

• The White Sox rank 4th in the league for walks this season (584).
• The White Sox rank 5th in the league for runs scored this season (760).
• The Rockies rank 30th in the league for ERA this season (5.59).
• The Rockies rank 30th in the league for strikeouts this season (1092).

Rockies vs White Sox Prediction

Both teams are tied 5-5 in their last 10 meetings and the Reds are 3-1 in their last 4 visits in Toronto.

In this Rockies vs White Sox Prediction, the Blue Jays are coming as -225 home favorites. The White Sox are playing for the NL Central title and have been in excellent form, with a 4-1 record in their last 5 games, having scored 8+ runs in three of their last four games. They also have the best pitcher on the mound, as Sean Burke goes up against a struggling Tomoyuki Sugano, who has given up 5+ runs in five of his last seven starts. Take the White Sox to win this one comfortably and cover the ruline.

Nikos Lagouretos's Pick: Chicago White Sox -1.5