Cleveland Guardians vs Chicago White Sox Prediction 8/10/2025 Today’s MLB Picks

The Cleveland Guardians and the Chicago White Sox meet Sunday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Cleveland Guardians will send out Slade Cecconi for the start here and Cecconi is 5-4 with a 3.72 ERA and 69 strikeouts this season. This will be Cecconi’s first career start against the White Sox. Davis Martin will start this one for the White Sox and is 3-9 with a 4.11 ERA and 68 strikeouts this season. In his career, Martin is 0-2 with a 9.00 ERA and 7 strikeouts against the Guardians.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to add on to their 3-1 win over the White Sox from Saturday’s matchup to improve to 61-55 this season. After this series, the Guardians will head home for a series against the Miami Marlins.

Guardians Win 5 In A Row

Steven Kwan has 122 hits as part of a .284 batting average and 9 home runs, 20 doubles and 39 RBIs. Kyle Manzardo has 74 hits with 13 doubles, 2 triples, 18 home runs and 49 RBIs as well this year. Gabriel Arias has 19 doubles but also 100 strikeouts and Manzardo has 91 strikeouts so far this season. Arias has also added 8 home runs and 40 RBIs and Jose Ramirez has chipped in 23 home runs and 61 RBIs with 32 stolen bases as well. Carlos Santana has also added 84 hits with 11 home runs and 47 RBIs as well this season.

Why the Cleveland Guardians will win

• The Guardians have won 12 of their last 13 games against the White Sox.
• The White Sox have lost each of their last six games.
• The road team has covered the run line in each of the Guardians’ last eight games.
• The White Sox have failed to cover the run line in five of their last six games.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in each of the Guardians’ last two day games against opponents that held a losing record.
• Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.
• Lane Thomas has recorded at least one hit in each of his 12 previous road appearances against AL Central opponents that held a losing record.
• Jose Ramirez ranks 3rd in the league in Steals (33) this season.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to rebound from their loss at the hands of Cleveland last time out to sit at 42-75 this season. After this series, the White Sox will welcome the Detroit Tigers to town for a divisional series.

White Sox Lose 6 Straight

Lenyn Sosa has 97 hits including 16 doubles and 45 RBIs. Andrew Benintendi has 69 hits including 13 doubles, 14 home runs, 44 RBIs and a .226 batting average while Miguel Vargas has 90 hits, 25 doubles, 13 home runs and 44 RBIs. Brooks Baldwin has also added 25 RBIs while Luis Robert Jr. has a team-high 31 stolen bases along with 46 RBIs so far this season. Chase Meidroth has added 78 hits with 11 stolen bases as well as 12 doubles this season.

Why the Chicago White Sox will win

• The White Sox have won nine of their last 12 games as underdogs against American League opponents following a home loss.
• The Guardians have lost four of their last five day games against American League opponents.
• The White Sox have covered the run line each of their last eight day games against teams that held a winning record.
• The Guardians have failed to cover the run line each of their last five day games against teams that held a losing record.

Chicago White Sox Player Prop Facts

• Michael A. Taylor has hit a home run in three of the White Sox’s last four games as underdogs.
• Michael A. Taylor has recorded at least one hit in each of his last six appearances in day games against teams that held a winning record.
• Luis Robert ranks 5th in the league in Steals (31) this season.

Total Runs Facts

• Four of the Guardians’ last five road games after playing the previous day have gone UNDER the total runs line.
• Three of the White Sox’s last four day games after playing the previous day have gone OVER the total runs line.

Cleveland Guardians vs. Chicago White Sox Prediction

I’m on the Guardians here. Davis Martin is still a decent option for the White Sox so far this season, but the White Sox have really cooled off in a big way in the last week or so, while the Guardians are playing some of their best baseball of the entire year and are doing so at the best possible time as they’re trying to make up ground in the AL Central race behind the Detroit Tigers. You could make a case that Cecconi has been Cleveland’s staff ace this season and I think that the Guardians back him up for the win here. Give me Cleveland.