Cleveland Guardians vs Boston Red Sox Prediction 9/2/2025 Today’s MLB Picks

The Cleveland Guardians and the Boston Red Sox meet Tuesday in MLB action from Fenway Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs. Boston Red Sox prediction.

Starting Pitching Matchup

The Cleveland Guardians will send out Slade Cecconi here and Cecconi is 5-6 with a 4.41 ERA and 83 strikeouts this season. This will be Cecconi’s first career start against the Guardians. Garrett Crochet will get the start for the Red Sox here and is 14-5 with a 2.40 ERA and 214 strikeouts this season. This will be Crochet’s second career start against the Guardians.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to bounce back from their series-opening 6-4 loss at the hands of the Red Sox to fall to 68-68 this season. After this series, the Guardians will head on the road for a series against the Tampa Bay Rays.

Guardians Drop Back-To-Back Games

Steven Kwan has 139 hits as part of a .270 batting average and 10 home runs, 23 doubles and 43 RBIs. Kyle Manzardo has 89 hits with 14 doubles, 2 triples, 23 home runs and 60 RBIs as well this year. Gabriel Arias has 20 doubles but also 129 strikeouts and Manzardo has 114 strikeouts so far this season. Arias has also added 9 home runs and 45 RBIs and Jose Ramirez has chipped in 26 home runs and 68 RBIs with 36 stolen bases as well. Carlos Santana has also added 89 hits with 11 home runs and 52 RBIs as well this season.

Why the Cleveland Guardians will win

• The Guardians have won each of their last seven night games against teams that held a winning record.
• The Red Sox have lost three of their last four games as home favorites against American League opponents.
• The Guardians have covered the run line each of their last 11 night games against teams that held a winning record.
• The Red Sox have failed to cover the run line in each of their last three night games against the Guardians following a win.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in three of the Guardians’ last four road games against AL opponents that held a winning record.
• Steven Kwan has recorded a Double in three of the Guardians’ last four games against the Red Sox.
• Steven Kwan has recorded at least one hit in each of the Guardians’ last eight games against opponents that held a winning record.
• Jose Ramirez ranks T3rd in the league in Steals (36) this season.

Boston Red Sox Recap

The Boston Red Sox come into this game looking to add on to their series-opening win over Cleveland last time out to improve to 77-62 on the year. After this series, the Red Sox will head on the road for an interleague set against the Arizona Diamondbacks.

Red Sox Pick Up 6th Win In Last 8 Games

Alex Bregman has 99 hits including 24 doubles along with 16 home runs and 53 RBIs this season. Trevor Story’s added 132 hits with 22 home runs, 84 RBIs and 24 stolen bases while Jarren Duran has 138 hits with 35 doubles, 12 triples, 14 home runs, 76 RBIs and a team-high 22 stolen bases. Roman Anthony’s added 72 hits with 18 doubles, 8 home runs and 31 RBIs while Wilyer Abreu has 22 home runs with 69 RBIs and 6 stolen bases and Ceddanne Rafaela has 15 homers, 29 doubles, 3 triples, 56 RBIs and 19 stolen bases this season.

Why the Boston Red Sox will win

• The Guardians have lost each of their last six road games.
• The Red Sox have won eight of their last nine games against American League opponents.
• The Guardians have failed to cover the run line each of their last five games against AL East opponents that held a winning record.
• The Red Sox have covered the run line in seven of their last eight home games against American League opponents following a win.

Boston Red Sox Player Prop Facts

• Trevor Story has recorded at least one hit in each of his last 13 home appearances against AL Central opponents.
• Connor Wong has hit a home run in three of his last four appearances with the Red Sox as favorites against the Guardians.
• Garrett Crochet ranks 2nd in the league for total Strikeouts (214) this season.

Total Runs Facts

• Each of the Red Sox’s last six games against AL Central opponents have gone OVER the total runs line.
• Each of the Guardians’ last four games as underdogs against the Red Sox have gone OVER the total runs line.

Cleveland Guardians vs. Boston Red Sox Prediction

I’m on the Red Sox in this game. I get the case to be made for a big underdog in certain spots, but Cecconi has really regressed over the second half of the season, Crochet has been elite, and the Guardians have been a team that has really struggled against lefties all season long. I think the Red Sox in their current form keep rolling here so give me Boston.