Jul 21, 2025; Cleveland, Ohio, USA; Baltimore Orioles shortstop Gunnar Henderson (2) hits an RBI single in the first inning against the Cleveland Guardians at Progressive Field. Mandatory Credit: David Richard-Imagn Images

Cleveland Guardians vs Baltimore Orioles Prediction 07/24/2025 Picks

Pick details

Baltimore (44-57) vs Cleveland (51-50)

July 24, 2025 at 01:10 PM EDT

The Line: Betting Odds: Cleveland -115 — Over/Under: +9

(Get latest betting odds)

The Baltimore Orioles and the Cleveland Guardians meet Thursday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Baltimore Orioles vs. Cleveland Guardians prediction.

Starting Pitching Matchup

The Baltimore Orioles will send out Charlie Morton for the start here and Morton is 5-8 with a 5.58 ERA and 92 strikeouts this season. In his last five starts against the Guardians, Morton is 3-1 with a 2.76 ERA and 31 strikeouts. Logan Allen will get the start for Cleveland here and is 6-8 with a 4.06 ERA and 74 strikeouts this season. In his career, Allen is 2-0 with a 3.45 ERA and 21 strikeouts against the Orioles.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to rebound from a 3-2 loss at the hands of the Guardians last time out to sit at 44-57 on the year. After this series, the Orioles will head home for a series against the Colorado Rockies.

Orioles Lose Three Straight & 7 Of Their Last 8


Cedric Mullins has 62 hits so far this season as well as 14 doubles, 13 home runs and 42 RBIs with 14 stolen bases and a .216 batting average while Adley Rutschman has 55 hits with 9 doubles, 8 homers and 20 RBIs. Jackson Holliday has 95 hits with 14 doubles, 2 triples, 13 homers and 39 RBIs. Ryan Mountcastle has 46 hits with 13 doubles, 2 homers and 15 RBIs and Gunnar Henderson has a team-high 95 strikeouts as well this season. Ryan O’Hearn’s also chipped in 80 hits with 14 doubles and 12 home runs with 36 RBIs and Heston Kjerstad’s added 4 homers and 19 RBIs.

Cleveland Guardians Recap


The Cleveland Guardians come into this game looking to add on to their win over the Orioles from Wednesday’s matchup to sit at 51-50 this season. After this series, the Guardians will head on the road for a series with the Kansas City Royals.

Guardians Win 4 Straight & 7 Of Their Last 8

Steven Kwan has 105 hits as part of a .288 batting average and 6 home runs, 20 doubles and 32 RBIs. Kyle Manzardo has 60 hits with 12 doubles, 2 triples, 16 home runs and 38 RBIs as well this year. Gabriel Arias has 17 doubles but also 88 strikeouts and Manzardo has 76 strikeouts so far this season. Arias has also added 6 home runs and 31 RBIs and Jose Ramirez has chipped in 20 home runs and 55 RBIs with 29 stolen bases as well. Carlos Santana has also added 75 hits with 11 home runs and 43 RBIs as well this season.

Baltimore Orioles vs. Cleveland Guardians Prediction

I’m on the Guardians here. I just think that this is a bad matchup for the Orioles facing a lefty, as they’ve been one of the weaker lineups in baseball all season when it comes to facing southpaws and I think that the Orioles could struggle again in this one. The Guardians are still a decent lineup that’s been trending in the right direction in recent weeks and I just think they’re the play at this price. Give me Cleveland here.

Chris Ruffolo's Pick: Cleveland -115

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