Cincinnati Reds vs Toronto Blue Jays Prediction 9/25/2026 Today’s MLB Picks

In this article, we will formulate a Reds vs Blue Jays Prediction for this MLB matchup on Friday, September 25th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Toronto Blue Jays Preview

The Toronto Blue Jays have a 77-82 record this season and are sitting in the 5th place of the AL East. They have a 40-38 home record and are coming off a 2-4 road loss against the Orioles.

The Toronto Blue Jays have a .248 batting average this season, .310 OBP and .382 Slugging percentage. Toronto’s pitching staff has a 3.92 ERA and 1.30 WHIP. Ernie Clement is the team’s best hitter with a .264 batting average. Kazuma Okamoto leads the team in RBI with 89, adding a team-high 33 home runs.

Jose Soriano (R) is the projected starting pitcher for the Blue Jays, and he has a 12-8 record, 3.72 ERA and 1.26 WHIP.

Cincinnati Reds Preview

The Cincinnati Reds have a 74-85 record this season and are sitting in the 5th place of the NL Central. They have a 36-42 away record and are coming off a 7-6 road win against the Braves.

The Cincinnati Reds have a .228 batting average this season, .305 OBP and .395 Slugging percentage. Cincinnati’s pitching staff has a 4.85 ERA and 1.45 WHIP. Elly De La Cruz is the team’s best hitter with a .285 batting average. Sal Stewart leads the team in RBI with 110, adding a team-high 32 home runs.

Nick Lodolo (L) is the projected starting pitcher for the Reds, and he has a 3-6 record, 5.04 ERA and 1.47 WHIP.

Cincinnati Reds @ Toronto Blue Jays Betting Trends: September 25, 2026

• Probable Starting Pitcher: Jose Soriano      Record this season: 12-8      ERA: 3.72
• Home Record: 4-2
• Last 5 against Reds: 1-1

Why the Toronto Blue Jays will win

• The Reds have lost each of their last eight night games following a win.
• The Blue Jays have won eight of their last nine night games against NL Central opponents following a loss.
• The Reds have failed to cover the run line each of their last 11 night games against AL opponents that held a losing record.
• The Blue Jays have covered the run line in each of their last eight games against NL Central opponents following a road loss.
• The Reds have trailed after 5 innings in each of their last six games against opponents that held a losing record.
• The Reds have trailed after 3 innings in four of their last five games against opponents that held a losing record.
• The Blue Jays have won the first inning in four of their last five games as favorites against the Reds.

• Probable Starting Pitcher: Nick Lodolo      Record this season: 3-6      ERA: 5.04
• Road Record: 1-2
• Last 5 against Blue Jays: –

Why the Cincinnati Reds will win

• The Blue Jays have lost four of their last five games as favorites.
• The Reds have won three of their last four games as road underdogs.
• The Blue Jays have failed to cover the run line each of their last six night games against teams that held a losing record.
• The road team has covered the run line in each of the Reds’ last five games.
• The Blue Jays have trailed after 5 innings in five of their last six night games at Rogers Centre against NL opponents.
• The Blue Jays have trailed after 3 innings in four of their last five games against opponents that held a losing record.

Total Runs Facts

• Each of the last seven games between the Reds and Blue Jays have gone OVER the total runs line.
• Seven of the Reds’ last eight games as underdogs against AL East opponents have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of the Reds’ last four games at Rogers Centre.
• There has been at least one run scored in the first inning in four of the Blue Jays’ last five games.

Toronto Blue Jays Player Prop Facts

• George Springer has hit at least one home run in four of the Blue Jays’ last five games against the Reds.
• George Springer has recorded at least one hit in each of the Blue Jays’ last 13 games against NL Central opponents that held a losing record.
• Jose Soriano has recorded six or more strikeouts in each of his last six home appearances against NL opponents.
• Jose Soriano has recorded a win in three of his last four appearances with his team as a favorite .

Cincinnati Reds Player Prop Facts

• Eugenio Suarez has hit a home run in three of his last four road appearances against AL opponents.
• Nick Lodolo has recorded five or more strikeouts in each of his last seven road appearances against opponents that held a losing record.
• Eugenio Suarez has recorded at least one hit in each of his last eight appearances against the Blue Jays.
• Elly De La Cruz ranks 8th amongst qualified players for Slugging Percentage (.521) this season.

Matchup/League Facts

• The Blue Jays rank 30th in the league for runs scored this season (636).
• The Blue Jays rank 30th in the league for home runs this season (150).
• The Reds rank 30th in the league for hits this season (1206).
• The Reds rank 30th in the league for batting average this season (.228).

Reds vs Blue Jays Prediction

Both teams are tied 5-5 in their last 10 meetings and the Reds are 3-1 in their last 4 visits in Toronto.

In this Reds vs Blue Jays Prediction, the Blue Jays are coming as -135 home favorites. Both teams have nothing to play for and I like the Jays at home in this one. Soriano has been in bad shape, but Lodolo has been even worse, sitting on a 5.97 road ERA. On top of that, Toronto has a better bullpen and Cincinnati’s bats have been struggling lately, averaging just 3.1 runs per game in their last 10. Take the Blue Jays to win.

Nikos Lagouretos's Pick: Toronto Blue Jays ML