Cincinnati Reds vs St. Louis Cardinals Prediction 7/25/2026 Today’s MLB Picks

In this article, we will formulate a Reds vs Cardinals Prediction for this MLB matchup on Saturday, July 25th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

St. Louis Cardinals Preview

The St. Louis Cardinals have a 52-51 record this season and are sitting in the 4th place of the NL Central. They have a 26-28 home record and are coming off a 2-4 home loss against the Reds. They will face the Cubs and the Blue Jays next.

The St. Louis Cardinals have a .240 batting average this season, .316 OBP and .382 Slugging percentage. St. Louis’s pitching staff has a 4.17 ERA and 1.34 WHIP. Jordan Walker is the team’s best hitter with a .288 batting average, leads the team in RBI with 77, and adds a team-high 22 home runs.

Andre Pallante (R) is the projected starting pitcher for the St. Louis Cardinals, and he has a 10-6 record, 4.02 ERA and 1.26 WHIP.

Cincinnati Reds Preview

The Cincinnati Reds have a 48-54 record this season and are sitting in the 5th place of the NL Central. They have a 26-26 away record and are coming off a 4-2 road win against the Cardinals. They will face the Guardians and the Pirates next.

The Cincinnati Reds have a .230 batting average this season, .309 OBP and .400 Slugging percentage. Cincinnati’s pitching staff has a 4.53 ERA and 1.43 WHIP. Elly De La Cruz is the team’s best hitter with a .276 batting average. Sal Stewart leads the team in RBI with 75, adding a team-high 21 home runs.

Hunter Greene (R) is the projected starting pitcher for the Cincinnati Reds, and he has a 2-1 record, 6.06 ERA and 1.16 WHIP.

Cincinnati Reds @ St. Louis Cardinals Betting Trends: July 25, 2026

• Probable Starting Pitcher: Andre Pallante      Record this season: 10-6      ERA: 4.02
• Home Record: 4-6
• Last 5 against Reds: 2-3

Why the St. Louis Cardinals will win

• The Reds have lost each of their last six Saturday night games at Busch Stadium.
• The home team has won four of the last five games between the Reds and Cardinals.
• The Cardinals have covered the run line in four of their last five games against National League opponents that held a losing record.
• The Reds have failed to cover the run line in three of their last four games against the Cardinals following a win.
• The Cardinals have led after 3 innings in three of their last four games against National League opponents that held a losing record.
• The Cardinals have led after 5 innings in each of their last four night games against National League opponents that held a losing record.
• The Cardinals have won the first inning in three of their last four home games.

• Probable Starting Pitcher: Hunter Greene      Record this season: 2-1      ERA: 6.06
• Road Record: 1-0
• Last 5 against Cardinals: 2-2

Why the Cincinnati Reds will win

• The Cardinals have lost each of their last four games as favorites.
• The Reds have won five of their last six games as road underdogs.
• The Cardinals have failed to cover the run line in 13 of their last 14 games as favorites after playing the previous day.
• The Reds have covered the run line in eight of their last nine games as underdogs against the Cardinals following a win.
• The Reds have led after 5 innings in each of their last six Saturday night games as road underdogs.

Total Runs Facts

• Each of the Reds’ last six night games against NL Central opponents have gone UNDER the total runs line.
• Each of the Cardinals’ last five night games after playing the previous day have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in seven of the Reds’ last eight road games against National League opponents.
• There has been no run scored during the first inning in each of the Cardinals’ last four games as favorites against NL Central opponents.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in three of the Cardinals’ last four games against NL opponents that held a losing record.
• Andre Pallante has recorded a win in three of his last four appearances with the Cardinals as favorites.
• Andre Pallante has recorded five or more strikeouts in each of his last five appearances against opponents that held a losing record.
• Jordan Walker has recorded at least one hit in each of the Cardinals’ last eight Saturday games as favorites.
• Jordan Walker ranks T8th in the league in Hits (112) this season.

Cincinnati Reds Player Prop Facts

• Eugenio Suarez has hit a home run in each of the Reds’ last four games against opponents that held a winning record.
• Hunter Greene has recorded a win in three of his last four appearances against opponents that held a winning record.
• Hunter Greene has recorded seven or more strikeouts in each of his last four appearances against NL Central opponents.
• Tyler Stephenson has recorded at least one hit in each of his last 16 road appearances against NL opponents.
• Elly De La Cruz is one of only seven players to record 10+ Home Runs and 4+ Triples this season.

Matchup/League Facts

• The Cardinals rank T2nd in the league for home runs allowed this season (102).
• The Cardinals rank T2nd in the league for home runs allowed this season (102).
• The Reds rank 29th in the league for hits this season (788).
• The Reds rank 29th in the league for hits this season (788).

Reds vs Cardinals Prediction

The Cardinals are 3-1 in their last 4 meetings against the Reds and are 3-1 in their last 4 meetings in Cincinnati.    

In this Reds vs Cardinals Prediction, the Cardinals are coming as -120 home favorites. I don’t like the pitching in this matchup, as both pitchers have a combined 10.08 ERA and Pallante has been in poor form with a 5.71 ERA across his last three starts and much weaker at home with a 4.99 ERA. Both bullpens have been the third and fourth-worse in baseball after the break, so I’m expecting runs in this game. Take the over 8 in this one.

Nikos Lagouretos's Pick: Over 8