Cincinnati Reds vs San Diego Padres Prediction 9/10/2025 Today’s MLB Picks

The Cincinnati Reds and San Diego Padres meet Wednesday in MLB action at Petco Park. Here’s a Cincinnati Reds vs San Diego Padres Prediction. This article will include a Cincinnati Reds vs San Diego Padres Pick.

Cincinnati Reds Betting Preview

The Cincinnati Reds are 73-72 on the year and play the Athletics, Cardinals, and Cubs next. The Cincinnati Reds are batting .246 on the season, have a .316 OBP, and a .392 slugging percentage. The Cincinnati Reds pitching staff has a 3.93 ERA and a 1.24 WHIP. Elly De La Cruz leads the Cincinnati Reds with 152 hits and 81 RBI, while TJ Friedl and Spencer Steer have combined for 248 hits and 111 RBI.

Andrew Abbott gets the ball for the Cincinnati Reds, and he is 8-6 with a 2.88 ERA and 130 strikeouts this season. Abbott is 1-0 with a 0.92 ERA and 18 strikeouts in his career against the San Diego Padres.

San Diego Padres Betting Preview

The San Diego Padres are 79-66 on the year and play the Rockies, Mets, and White Sox next. The San Diego Padres are batting .252 on the season, have a .321 OBP, and a .386 slugging percentage. The San Diego Padres pitching staff has a 3.66 ERA and a 1.21 WHIP. Luis Arraez leads the San Diego Padres with 158 hits and 54 RBI while Manny Machado and Fernando Tatis Jr. have combined for 296 hits and 146 RBI.

Nick Pivetta gets the ball for the San Diego Padres, and he is 13-5 with a 2.85 ERA and 172 strikeouts this season. Pivetta is 1-1 with a 3.41 ERA and 35 strikeouts in his career against the Cincinnati Reds.

Cincinnati Reds @ San Diego Padres Betting Trends: September 10, 2025

• Probable Starting Pitcher: Nick Pivetta      Record this season: 13-5      ERA: 2.85
• Home Record: 8-1
• Last 5 against Reds: 0-0

Why the San Diego Padres will win

• The Padres have won 13 of their last 14 home games against National League opponents following a home loss.
• The Reds have lost each of their last five games against the Padres following a win.
• The Padres have covered the run line in each of their last six Wednesday games against the Reds.
• The Reds have failed to cover the run line in four of their last five games against the Padres following a win.
• The Reds have trailed after 5 innings in seven of their last nine games at Petco Park against National League opponents that held a winning record.

• Probable Starting Pitcher: Andrew Abbott      Record this season: 8-6      ERA: 2.88
• Road Record: 4-2
• Last 5 against Padres: 1-0

Why the Cincinnati Reds will win

• The Padres have lost four of their last five games as home favorites after playing the previous day.
• The road team has won six of the Padres’ last eight games.
• The Padres have failed to cover the run line in each of their last six games at Petco Park.
• The underdogs have covered the run line in seven of the Padres’ last eight games at Petco Park.
• The Reds have won the first inning in each of their last three games at Petco Park.
• The Reds have led after 3 innings in four of their last five games at Petco Park.

Total Runs Facts

• Five of the Reds’ last six games as road underdogs have gone UNDER the total runs line.
• Five of the Padres’ last six night games against NL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Padres’ last four games at Petco Park.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Reds’ last five games at Petco Park.

San Diego Padres Player Prop Facts

• Jake Cronenworth has recorded at least one hit in each of his last nine home appearances against NL Central opponents that held a winning record.
• Nick Pivetta has recorded seven or more strikeouts in five of his last six appearances with the Padres as home favorites against NL opponents.
• Nick Pivetta has recorded a win in each of his last three home appearances against NL Central opponents.
• Jake Cronenworth has hit a home run in three of his last six home appearances against NL Central opponents that held a winning record.
• Manny Machado ranks T7th in the league in Hits (155) this season.

Cincinnati Reds Player Prop Facts

• Austin Hays has hit a home run in two of the Reds’ last three games as underdogs against NL opponents.
• Miguel Andujar has recorded at least one hit in each of his last 11 Wednesday night appearances with his team as an underdog.

Matchup/League Facts

• The Padres rank 29th in the league for home runs this season (127).
• The Padres rank 2nd in the league for runs allowed this season (563).
• The Reds rank 23rd in the league for home runs this season (146).
• The Reds rank 22nd in the league for strikeouts against this season (1265).

Cincinnati Reds vs San Diego Padres Prediction

Abbott has been solid this season overall, but he’s been shaky lately, allowing 37 hits and 20 earned runs in his last 35 innings. Abbott has also walked 5 in his last 9.2 innings. Pivetta has allowed 26 hits and 14 earned runs in his last 42.2 innings, and he has a 2.39 ERA and .171 allowed batting average in 90.1 home innings. In 60 at bats against current Reds, Pivetta is allowing a .183 batting average and .246 on base percentage, with 14 strikeouts. The Padres should win this game at home with a pitcher who is in great form. Give me the Padres.