Cincinnati Reds vs Arizona Diamondbacks Prediction 8/22/2026 Today’s MLB Picks

The Cincinnati Reds and the Arizona Diamondbacks meet Friday in MLB action from Chase Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cincinnati Reds vs. Arizona Diamondbacks prediction.

Starting Pitching Matchup

The Cincinnati Reds will send out Rhett Lowder for the start here and Lowder is 4-8 with a 5.17 ERA and 82 strikeouts this season. Michael Soroka will start for the Diamondbacks here and is 8-3 with a 2.93 ERA and 88 strikeouts this season. 

Cincinnati Reds Recap

The Cincinnati Reds come into this game looking to rebound from a 9-0 loss at the hands of the Diamondbacks on Friday to fall to 61-68 this season. After this series, the Reds will head on the road for a game against the San Francisco Giants.

Reds Drop 7 Of Last 9

Elly De La Cruz has 111 hits with 19 doubles, 5 triples, 20 home runs and 57 RBIs while Sal Stewart has 127 hits with 24 doubles, 27 home runs and 96 RBIs. Spencer Steer has 81 hits with 14 doubles, 16 home runs and 40 RBIs and Matt McLain has 67 hits with 17 doubles, 12 home runs and 33 RBIs. JJ Bleday’s added 77 hits with 13 doubles, 20 home runs and 48 RBIs as well on the year.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to add on to their win over the Reds from Friday to sit at 68-61 on the year. After this game, Arizona will take on the Chicago Cubs in a matchup at home.

Diamondbacks Win Back-To-Back Games

Corbin Carroll has 116 hits including 27 doubles, 15 triples, 18 home runs and 57 RBIs. Ketel Marte has 117 hits with 23 doubles, 3 triples, 21 home runs and 67 RBIs and Geraldo Perdomo has 111 hits, with 18 doubles, 6 triples, 9 home runs and 44 RBIs as well this season. Nolan Arenado also has 101 hits with 20 doubles, 20 home runs and 64 RBIs and Gabriel Moreno has 111 hits with 26 doubles, 10 home runs and 63 RBIs this season. Ildemaro Vargas also has 96 hits with 17 doubles, 4 triples, 9 home runs and 61 RBIs.

Cincinnati Reds @ Arizona Diamondbacks Betting Trends: August 22, 2026

• Probable Starting Pitcher: Michael Soroka      Record this season: 8-3      ERA: 2.93
• Home Record: 4-2
• Last 5 against Reds: 0-2

Why the Arizona Diamondbacks will win

• The Reds have lost seven of their last eight night games against the Diamondbacks following a loss.
• The Diamondbacks have won six of their last seven games against NL Central opponents.
• The Reds have failed to cover the run line in eight of their last nine night games against National League opponents.
• The Diamondbacks have covered the run line in each of their last five games against NL Central opponents.
• The Diamondbacks have won the first inning in each of their last five home games.
• The Reds have trailed after 3 innings in each of their last nine games at Chase Field.
• The Reds have trailed after 5 innings in each of their last seven road night games.

• Probable Starting Pitcher: Rhett Lowder      Record this season: 4-8      ERA: 5.17
• Road Record: 2-7
• Last 5 against Diamondbacks: 0-0

Why the Cincinnati Reds will win

• The Reds have won five of their last six games as underdogs following a road loss.
• The Diamondbacks have lost three of their last four games as favorites after playing the previous day.
• The Reds have covered the run line in eight of their last nine games as underdogs against the Diamondbacks following a road loss.
• The Diamondbacks have failed to cover the run line in seven of their last eight games as home favorites against the Reds following a home win.
• The Diamondbacks have trailed after 3 innings in four of their last five games.
• The Reds have led after 5 innings in each of their last six Saturday night games as road underdogs.

Total Runs Facts

• Eight of the Reds’ last nine road games against NL West opponents have gone OVER the total runs line.
• Each of the Diamondbacks’ last four games have gone OVER the total runs line.
• There has been at least one run scored in the first inning in each of the Reds’ last six games against NL West opponents.
• There has been at least one run scored in the first inning in seven of the Diamondbacks’ last eight games against National League opponents.

Arizona Diamondbacks Player Prop Facts

• Corbin Carroll has recorded at least one hit in each of the Diamondbacks’ last seven games against NL opponents.
• Jordan Lawlar has hit a home run in each of his last two home appearances against NL opponents.
• Gabriel Moreno ranks 4th amongst qualified players for Batting Average (.308) this season.

Cincinnati Reds Player Prop Facts

• Eugenio Suarez has hit a home run in three of his last five appearances with his team as a road underdog against NL West opponents.
• Rhett Lowder has recorded four or more strikeouts in nine of his last 10 appearances with the Reds as underdogs.
• Sal Stewart has recorded at least one hit in each of the Reds’ last 12 road games against NL opponents that held a winning record.

Matchup/League Facts

• The Diamondbacks rank 1st in the league for triples this season (33).
• The Diamondbacks rank 2nd in the league for strikeouts against this season (940).
• The Reds rank 30th in the league for hits this season (962).
• The Reds rank 30th in the league for batting average this season (.225).

Cincinnati Reds vs. Arizona Diamondbacks Prediction

I’m on the Diamondbacks here. The Reds are just in poor form and I don’t expect that to change with Lowder on the road where he’s struggled for much of the year. Arizona’s been playing the much better baseball and for a lot of the year, Soroka was considered the 1 or 2 in this Arizona starting rotation. I think the Diamondbacks pick up another W here. Give me Arizona.

Chris Ruffolo's Pick: Arizona -165