Chicago White Sox vs St. Louis Cardinals Prediction 9/13/2026 Today’s MLB Picks

The Chicago White Sox and the St. Louis Cardinals will meet Sunday afternoon in the final game of a three-game interleague series at Busch Stadium in St. Louis, Missouri. Let’s take a look at this matchup from a betting perspective.

Chicago White Sox Betting Preview

The Chicago White Sox enter Sunday’s matchup with a 76-72 overall record (1st in American League Central) and a 33-41 mark on the road. The White Sox offense has performed exceptionally well this season. Chicago has compiled 694 runs scored (7th in MLB), 233 doubles, a .235 team batting average and 193 home runs which ranks sixth in Major League Baseball.

The White Sox arrive at this contest in below average form. Chicago has lost four of the team’s last five games, including a 7-3 loss to the St. Louis Cardinals earlier this week.

The Chicago White Sox will turn to right hander Sean Burke in this game. In 25 starts made in 2026, Burke has compiled an 8-7 win-loss record, a 3.58 ERA, a 1.20 WHIP and 169 strikeouts (20th in MLB) in 156 innings pitched. Sean Burke struggled in his most recent outing, allowing seven earned runs, eight hits and two walks across 1.1 innings pitched in the Pittsburgh Pirates 9-3 defeat of the White Sox five days ago. Burke will look to rebound from his recent poor performance on the mound in this afternoon’s matchup with the St. Louis Cardinals.

Shifting our focus to the Chicago offense, the White Sox lineup features Miguel Vargas and Tristan Peters. Vargas has tallied 30 home runs (14th in MLB), 79 RBIs, 30 doubles and an .828 OPS. Tristan Peters has amassed a .279 batting average, 12 home runs, 54 RBIs, 30 doubles, 34 walks and an .807 OPS.                                                              

St. Louis Cardinals Betting Preview

The St. Louis Cardinals enter Sunday afternoon’s matchup with a 73-76 overall record (4th in the National League Central) and a 35-39 mark at home. St. Louis has played below average baseball lately, losing four of the team’s last five games.

The Cardinals will start right hander Michael McGreevy in this contest. In 28 starts made in 2026, McGreevy has compiled a 6-9 win-loss record, a 3.92 ERA, a 1.25 WHIP, and 106 strikeouts in 154 innings pitched. Michael McGreevy arrives at this contest in good form, allowing only two earned runs across 6.2 innings pitched while striking out four batters in his most recent outing against the San Francisco Giants.

The Cardinals lineup features Alec Burleson and Jordan Walker. Alec Burleson has amassed a .283 batting average, 22 home runs, 104 RBIs (2nd in MLB) and an .816 OPS. Jordan Walker has compiled a .281 batting average, 28 home runs (20th in MLB), 100 RBIs and an .826 OPS.                    

Why the Chicago White Sox will win.

• Starting pitching. Sean Burke has compiled an 8-7 win-loss record, a 3.58 ERA, a 1.20 WHIP and 169 strikeouts (20th in MLB) in 156 innings pitched.

• Power potential. The Chicago White Sox have amassed 193 home runs which ranks sixth in Major League Baseball.

• Motivation. The Chicago White Sox have lost four of the team’s last five games.

Why the St. Louis Cardinals will win.

• Home field advantage. The St. Louis Cardinals have played competitive baseball at Busch Stadium.

• Starting pitching. Michael McGreevy has compiled a 6-9 record, a 3.92 ERA, a 1.25 WHIP, and 106 strikeouts in 154 innings pitched.  

Chicago vs. St. Louis Cardinals Prediction

In my view, this matchup favors the St. Louis Cardinals. Why? White Sox starting pitcher Sean Burke struggled in his most recent outing, allowing seven earned runs, eight hits and two walks across 1.1 innings pitched in the Pittsburgh Pirates 9-3 defeat of the White Sox five days ago. Conversely, St. Louis hurler Michael McGreevy arrives at this contest in good form, allowing only two earned runs across 6.2 innings pitched while striking out four batters in his most recent outing against the San Francisco Giants. For the reasons just noted, I am backing the St. Louis Cardinals on the moneyline in this game.

Hans Geevers's Pick: St. Louis Cardinals ML