Chicago White Sox vs St. Louis Cardinals Prediction 9/12/2026 Today’s MLB Picks

The Chicago White Sox and the St. Louis Cardinals meet Saturday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Chicago White Sox will send out Sean Newcomb for the start here and Newcomb is 2-4 with a 2.71 ERA and 74 strikeouts this season. Kyle Leahy will start for St. Louis and is 10-4 with a 3.41 ERA and 124 strikeouts this season.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to rebound from a 7-3 loss at the hands of St. Louis last time out to sit at 75-72 this season. After this series, the White Sox will head on the road for a series against the Cleveland Guardians.

White Sox Lose 4 Straight

Munetaka Murakami has 83 hits with 31 home runs and 64 RBIs while Miguel Vargas has 133 hits with 30 doubles, a triple, 30 home runs and 79 RBIs and Colson Montgomery has 109 hits with 23 doubles, 31 home runs and 83 RBIs. Luisangel Acuna has 46 hits and Tristan Peters has 112 hits with 30 doubles, 12 home runs and 53 RBIs so far this season. Chase Meidroth also has 140 hits with 27 doubles, 14 home runs and 53 RBIs this year.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to build on their win over Chicago last time out to sit at 73-75 this season. After this series, St. Louis will take on San Francisco at home.

Cardinals Snap Three-Game Slide

Jordan Walker has 159 hits, 33 doubles, 28 home runs and 100 RBIs while Alec Burleson has 159 hits with 35 doubles, 22 home runs and 106 RBIs. JJ Wetherholt has 122 hits with 17 home runs and 48 RBIs while Ivan Herrera has 138 hits with 25 doubles, 16 home runs and 64 RBIs. Masyn Winn’s added 103 hits with 19 doubles and 52 RBIs and Nathan Church has 95 hits with 10 home runs and 49 RBIs this season.

The Chicago White Sox @ St. Louis Cardinals Betting Trends: September 12, 2026

• Probable Starting Pitcher: Kyle Leahy      Record this season: 10-4      ERA: 3.41
• Home Record: 5-3
• Last 5 against White Sox: 0-1

Why the St. Louis Cardinals will win

• The White Sox have lost each of their last nine night games against NL Central opponents following a road loss.
• The Cardinals have won each of their last four games against the White Sox.
• The White Sox have failed to cover the run line in each of their last six games against NL opponents.
• The Cardinals have covered the run line in eight of their last nine home games after playing the previous day.
• The Cardinals have led after 3 innings in each of their last four games against the White Sox.
• The White Sox have trailed after 5 innings in each of their last six night games against NL opponents.
• The Cardinals have won the first inning in three of their last four games against AL Central opponents.

• Probable Starting Pitcher: Sean Newcomb      Record this season: 2-4      ERA: 2.71
• Road Record: 0-3
• Last 5 against Cardinals: 0-0

Why the Chicago White Sox will win

• The Cardinals have lost seven of their last eight games as favorites following a home win.
• The underdogs have won three of the White Sox’s last four games.
• The Cardinals have failed to cover the run line in each of their last 10 games as favorites following a win.
• The underdogs have covered the run line in nine of the Cardinals’ last 10 games at Busch Stadium.
• The Cardinals have lost the first inning in four of their last five games.
• The Cardinals have trailed after 5 innings in three of their last four night games.

Total Runs Facts

• Each of the Cardinals’ last seven night games against AL Central opponents have gone OVER the total runs line.
• Ten of the White Sox’s last 12 night games as underdogs have gone OVER the total runs line.
• There has been at least one run scored in the first inning in each of the Cardinals’ last six games as home favorites against AL Central opponents.
• There has been at least one run scored in the first inning in nine of the White Sox’s last 10 games as underdogs against NL Central opponents.

St. Louis Cardinals Player Prop Facts

• Nathan Church has recorded at least one hit in each of his last 12 appearances with the Cardinals as favorites.
• Kyle Leahy has recorded three or more strikeouts in each of his last nine appearances.
• Joshua Baez has hit at least one home run in three of the Cardinals’ last four Saturday games.
• Jordan Walker ranks T8th in the league in Hits (159) this season.

Chicago White Sox Player Prop Facts

• Chase Meidroth has hit at least one home run in each of the White Sox’s last two road games against NL opponents that held a losing record.
• Miguel Vargas has recorded at least one hit in each of the White Sox’s last 16 road games against NL opponents.
• Colson Montgomery ranks T10th in the league in Home Runs (31) this season.

Matchup/League Facts

• The Cardinals rank T4th in the league for home runs allowed this season (148).
• The Cardinals rank 26th in the league for slugging percentage this season (.386).
• The White Sox rank T5th in the league for walks this season (528).
• The White Sox rank T6th in the league for runs scored this season (688).

Chicago White Sox vs. St. Louis Cardinals Prediction

I’m on the Cardinals in this one. I just think that Leahy is the better starting option in this game and while Newcomb is likely an opener, I think that Leahy’s been a quietly underrated option in this Cardinal rotation. I think St. Louis finds a way to get the job done here so give me the Cardinals.

Chris Ruffolo's Pick: St. Louis -105