Chicago White Sox vs Cleveland Guardians Prediction 9/14/2026 Today’s MLB Picks

The Chicago White Sox and Cleveland Guardians meet Monday in MLB action at Progressive Field. Here’s a Chicago White Sox vs. Cleveland Guardians Prediction. This article will include a Chicago White Sox vs Cleveland Guardians Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 76-73 on the year and play the Tigers and Royals next. The Chicago White Sox are batting .235 on the season, have a .318 OBP, and have a .403 slugging percentage. The Chicago White Sox pitching staff has a 4.13 ERA and a 1.31 WHIP. Chase Meidroth leads the Chicago White Sox with 140 hits and 54 RBI, while Sam Antonacci and Miguel Vargas have combined for 254 hits and 123 RBI.

Sean Newcomb gets the ball for the Chicago White Sox, and he is 2-4 with a 2.77 ERA and 78 strikeouts this season. Newcomb is 0-1 with a 0.87 ERA and 13 strikeouts in his career against the Cleveland Guardians.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 76-74 on the year and play the Red Sox and Athletics next. The Cleveland Guardians are batting .237 this season, with a .315 OBP and a .374 slugging percentage. The Cleveland Guardians pitching staff has a 3.78 ERA and a 1.26 WHIP. Steven Kwan leads the Cleveland Guardians with 139 hits and 30 RBI, while Chase DeLauter and Brayan Rocchio have combined for 257 hits and 127 RBI.

Gavin Williams is 13-7 with a 3.78 ERA and 228 strikeouts this season. Williams is 1-1 with a 4.91 ERA and 35 strikeouts in his career against the Chicago White Sox.

Why the Cleveland Guardians will win

• The White Sox have lost seven of their last eight road games against the Guardians following a loss.
• The Guardians have won seven of their last eight games against the White Sox at Progressive Field following a win.
• The White Sox have failed to cover the run line in seven of their last eight games.
• The Guardians have covered the run line in four of their last five games against AL opponents.
• The Guardians have led after 3 innings in five of their last six home games against opponents that held a winning record.
• The Guardians have led after 5 innings in eight of their last nine Monday night games against the White Sox at Progressive Field.

Why the Chicago White Sox will win

• The Guardians have lost five of their last six games as favorites against AL Central opponents following a win.
• The White Sox have won four of their last five games as underdogs against the Guardians.
• The Guardians have failed to cover the run line in each of their last six home games.
• The White Sox have covered the run line in 10 of their last 11 games against the Guardians.

Total Runs Facts

• Each of the Guardians’ last four night games against AL Central opponents have gone UNDER the total runs line.
• Ten of the White Sox’s last 12 night games as underdogs have gone OVER the total runs line.
• There has been at least one run scored in the first inning in seven of the White Sox’s last eight games as road underdogs against AL Central opponents.
• There has been at least one run scored in the first inning in four of the Guardians’ last five home games against AL Central opponents.

Cleveland Guardians Player Prop Facts

• Gavin Williams has recorded 10+ strikeouts in six of his last seven appearances at Progressive Field.
• Steven Kwan has recorded at least one hit in each of his last 11 appearances against AL opponents that held a winning record.
• Austin Hedges has hit a home run in two of his last three home appearances against AL opponents that held a winning record.
• Jose Ramirez ranks T7th in the league in Steals (31) this season.

Chicago White Sox Player Prop Facts

• Colson Montgomery has hit a home run in each of the White Sox’s last two games at Progressive Field.
• Chase Meidroth has recorded at least one hit in each of his 10 previous Monday appearances against AL teams that held a winning record.

Matchup/League Facts

• The Guardians rank 3rd in the league for strikeouts this season (1415).
• The Guardians rank 27th in the league for runs scored this season (615).
• The White Sox rank 26th in the league for strikeouts against this season (1366).
• The White Sox rank 5th in the league for walks this season (540).

Chicago White Sox vs Cleveland Guardians Prediction

This series is crucial to who wins the AL Central, and the Guardians should have the edge at home. However, I’ve backed the White Sox a ton this season, and they’ve rewarded me by being the third most profitable team in baseball. The White Sox haven’t gotten respect all season, but they’ve turned a profit only the Brewers and Rays have topped. Williams has been solid, but you can argue Newcomb has been better with a 2.77 ERA and 1.14 WHIP. Like I have all season, I’m going to grab the White Sox at the more favorable price.

Randy Chambers's Pick: Chicago White Sox