Chicago Cubs vs San Diego Padres Prediction 4/14/25 MLB Picks

In this article, we will formulate a Cubs vs Padres prediction for this MLB game on Monday, April 14, at PETCO Park in San Diego, California. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Betting Preview

The Chicago Cubs (11-7, 7-3 Away) got revenge for the two-game series loss to the Los Angeles Dodgers in Tokyo with a series win in Los Angeles. The Dodgers did open with a 3-0 win, but the Cubs erupted for a 16-0 victory in Game 2 and concluded the series with a 4-2 win. Pete Crow-Armstrong led the offense with a couple of solo homers, while Chris Rea pitched for 3.2 innings in a no-decision, allowing one run on four hits with five strikeouts and one walk. Ethan Roberts was credited with a win.

This season, the Cubs average 6.44 runs per game (1st in the MLB) on a .256/.348/.439 slash line. Regarding pitching, the Cubs’ staff has a 4.02 ERA (18th) and 1.34 WHIP (21st). Kyle Tucker leads the Cubs with a .324 batting average, five home runs, and 15 RBI this season.

The projected starting pitcher for the Cubs is Jameson Taillon, who has a 1-1 record in three starts this year with a 6.06 ERA and 1.35 WHIP in 16.1 innings.

San Diego Padres Betting Preview

The San Diego Padres (13-3, 10-0 Home) continue to be the hottest team in baseball after sweeping the Colorado Rockies in three games without even allowing a single run! Prior to that, the Padres beat the A’s, lost to the Cubs, and swept the Guardians and Braves. In the latest 6-0 victory over the Rox, Jose Iglesias led the offense with two RBI, while Michael King recorded a complete-game shutout on two hits, with eight strikeouts and one walk.

This year, the Padres average 4.56 runs per game (10th in the MLB) on a .283/.348/.423 triple-slash. When it comes to pitching, the Padres’ staff has a 2.68 ERA (2nd) and 1.04 WHIP (2nd). Jackson Merrill leads the Padres with a .378 batting average, three home runs, and ten RBI this season.

Dylan Cease will take the mound for the Padres on Monday. The 29-year-old right-hander has a 1-1 record in three starts this season with a 7.98 ERA and 1.57 WHIP in 14.2 innings.

Total Runs Facts

• Each of the Cubs’ last five night games after playing the previous day have gone OVER the total runs line.
• Six of the Padres’ last seven home games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cubs’ last six games as road underdogs.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Padres’ last nine games as favorites against National League opponents.

Matchup/League Facts

• The Padres rank 1st in the league for opponent batting average this season (.181).
• The Padres rank 1st in the league for hits allowed this season (90).
• The Cubs rank 1st in the league for RBIs this season (113).
• The Cubs rank 1st in the league for steals this season (26).

Cubs vs Padres Prediction

The Padres won six of the previous ten H2H encounters, but the Cubs were better in two of the last three. Jameson Taillon and Dyaln Cease are not playing well early in the season, and this is an opportunity for the Over bettors to take and bet on Over. Taillon has a .306 BA in 111 at-bats against the Padres, and although Cease has better career-numbers against the Cubs, he is shaken following his latest start and nine allowed runs to the Athletics. Both will surrender multiple runs in the opening five innings.