Chicago Cubs vs Cincinnati Reds Prediction 9/19/2025 Today’s MLB Picks

In this article, we will formulate a Cubs vs Reds Prediction for this MLB game on Friday, September 19th at the Great American Ball Park in the second game of this series, with the Reds having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Cincinnati Reds Preview

The Cincinnati Reds have a 77-76 record this season and are sitting in the third place of the NL Central. The Reds have a 41-34 home record and are 57-88 in over/under. They are coming off a 1-0 home victory over the Cubs, and are 3-1 in their last 4 games. Under is 8-3 in their last 11 games and are playing the Pirates and the Brewers next.

The Reds have a .245 batting average this season, .316 OBP and .390 slugging percentage. Cincinnati’s pitching staff has a 3.94 ERA and 1.23 WHIP.  Elly De La Cruz leads the Reds with 156 hits, and in RBI, with 82, adding a team-high 19 home runs. Gavin Lux is the team’s best hitter with a .267 batting average.

Nick Lodolo (L) is the projected starting pitcher for the Reds, and he has an 8-8 record, 3.30 ERA and 1.04 WHIP.

Chicago Cubs Preview

The Chicago Cubs have an 88-65 record this season and are sitting on the second place of the NL Central. The Cubs have a 42-36 road record and are 68-73 in over/under. They are coming off a 0-1 road defeat by the Reds, that ended their four-game winning streak. Under is 9-4 in their last 13 games and are playing the Mets and the Cardinals next.

The Cubs have a .249 batting average this season, .321 OBP and .426 Slugging percentage. Chicago’s pitching staff has a 3.80 ERA and 1.18 WHIP. Nico Hoerner leads the Cubs with 168 hits, and he is the team’s best hitter with a .301 batting average. Seiya Suzuki leads the team in RBI, with 91, while Pete Crow-Armstrong adds a team-high 29 home runs.

Shota Imanaga (R) is the projected starting pitcher for the Cubs, and he has a 9-7 record, 3.29 ERA and 0.95 WHIP.

The Chicago Cubs @ Cincinnati Reds Betting Trends: September 19, 2025

• Probable Starting Pitcher: Nick Lodolo      Record this season: 8-8      ERA: 3.30
• Home Record: 3-2
• Last 5 against Cubs: 1-1

Why the Cincinnati Reds will win

• The Reds have won four of their last five games as underdogs against National League opponents.
• The Cubs have lost each of their last six Friday night games against teams that held a winning record.
• The Reds have covered the run line in each of their last six games as underdogs against National League opponents.
• The Cubs have failed to cover the run line each of their last six Friday night games against teams that held a winning record.
• The Reds have led after 3 innings in six of their last seven games as home underdogs against NL Central opponents.
• The Cubs have trailed after 5 innings in each of their last four games at Great American Ball Park.
• The Reds have won the first inning in each of their last four games as underdogs against the Cubs at Great American Ball Park.

• Probable Starting Pitcher: Shota Imanaga      Record this season: 9-7      ERA: 3.29
• Road Record: 5-5
• Last 5 against Reds: 1-0

Why the Chicago Cubs will win

• The Reds have lost each of their last four home games against NL Central opponents following a home win.
• The Cubs have won five of their last six road games.
• The Cubs have covered the run line in each of their last six road games.
• The Reds have failed to cover the run line in nine of their last 10 games at Great American Ball Park following a win.
• The Cubs have led after 3 innings in four of their last five night games against opponents that held a winning record.
• The Cubs have led after 5 innings in eight of their last 10 night games.

Total Runs Facts

• Each of the Cubs’ last nine night games against National League opponents have gone UNDER the total runs line.
• Seven of the Reds’ last eight games against National League opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last six games between the Cubs and Reds.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Cubs’ last six games as favorites.

Cincinnati Reds Player Prop Facts

• Nick Lodolo has recorded six or more strikeouts in each of his four previous home appearances against NL Central opponents that held a winning record.
• Austin Hays has recorded at least one hit in each of his last 11 appearances in night games.
• Spencer Steer has hit a home run in two of his last three appearances with the Reds as underdogs against NL Central opponents.
• Elly De La Cruz ranks T7th in the league in Steals (35) this season.

Chicago Cubs Player Prop Facts

• Seiya Suzuki has recorded at least one Double in each of the Cubs’ last five road games against the Reds.
• Ian Happ has hit a home run in three of the Cubs’ last four games as favorites.
• Shota Imanaga has recorded a win in four of his last five road appearances against opponents that held a winning record.
• Shota Imanaga has recorded five or more strikeouts in seven of his last eight appearances against opponents that held a winning record.
• Ian Happ has recorded at least one hit in each of the Cubs’ last seven road games against NL Central opponents that held a winning record.
• Nico Hoerner ranks T5th in the league in Hits (168) this season.

Matchup/League Facts

• The Reds rank 24th in the league for home runs this season (153).
• The Reds rank 8th in the league for opponent batting average this season (.235).
• The Cubs rank 1st in the league for walks allowed this season (387).
• The Cubs rank 3rd in the league for steals this season (154).

Cubs vs Reds Prediction

The Red are 3-1 in their last 4 head-to-head meetings against the Cubs, and both teams are tied 2-2 wins in their last 4 meetings in Cincinnati. Under is 6-1 in their last 7 meetings.

In this Cubs vs Reds Prediction, the Cubs are coming as -125 road favorites. This is a classic case of a pitcher’s duel between two southpaws. Both pitchers are coming into this matchup in bad form, and that is why the total is set at 8.5 runs. Yesterday’s game had only one total runs and both teams are far weaker against southpaws, averaging 8.1 runs per game combined againt lefties. Take the under 8.5 runs in this one.