Cardinals vs Nationals Prediction 4/6/2026 Today’s MLB Picks

In this article we will formulate a Cardinals vs Nationals prediction for this MLB game on Monday, April 6th at Nationals Park in Washington, DC. Let’s take a look at the prediction for this MLB matchup. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 5-4 this season after they lost two out of three against the Tigers by scores of 0-4, 6-11, and 5-3. In their game three win, St. Louis trailed 2-0 early in the game, but they scored five of the last six runs for the comeback victory. The Cardinals recorded six hits in the game and they were led by Herrera, who went 1-3 with two RBIs. Leahy allowed five hits and two earned runs over 5.0 innings for the win, while O’Brien got the save in the ninth. 

This season, St. Louis has a 4.94 ERA with a 1.56 WHIP and a .273 opponent batting average, while they have scored 40 runs with a .217 batting average and a .294 on base percentage. Jordan Walker has led the Cardinals with two home runs and eight RBIs, while Alec Burleson has added one home run and six RBIs. The projected starting pitcher for St. Louis is Andre Pallante, who is 1-0 with a 0.00 ERA and a 1.20 WHIP over 5.0 innings pitched this season. 

Washington Nationals Betting Preview

The Washington Nationals are 3-6 this year after they lost all three games against the Dodgers by scores of 6-13, 5-10, and 6-8. In their game three loss, Washington led 6-1 in the fourth inning, but they allowed seven runs in the last four innings for the tough loss. The Nationals recorded seven hits and they were led by Wood, who went 1-4 with one home run and four RBIs in the game. Griffin allowed five hits and one earned run over 5.0 innings in the no decision, while Perez allowed four earned runs in relief. 

This season, Washington has a 6.27 ERA with a 1.61 WHIP and a .283 opponent batting average, while they have scored 55 runs with a .270 batting average and a .340 on base percentage. CJ Abrams has led the Nationals with three home runs and 12 RBIs, while Joey Wiemer has added two home runs and four RBIs. The projected starting pitcher for Washington is Zack Littell, who is 0-1 with a 5.40 ERA and a 1.60 WHIP over 5.0 innings pitched this year. 

Why the Washington Nationals will win

• The Cardinals have lost 10 of their last 12 games as favorites following a win.
• The Nationals have won each of their last five games against NL Central opponents following a loss.
• The Cardinals have failed to cover the run line in each of their last 12 games as favorites following a win.
• The Nationals have covered the run line in each of their last five games against NL Central opponents following a loss.

Why the St. Louis Cardinals will win

• The Nationals have lost nine of their last 10 home games.
• The Cardinals have won each of their last five games at Nationals Park.
• The Nationals have failed to cover the run line in each of their last 10 games at Nationals Park.
• The road team has covered the run line in 13 of the Nationals’ last 14 games.
• The Nationals have trailed after 5 innings in each of their last four games at Nationals Park against NL Central opponents that held a winning record.
• The Nationals have trailed after 3 innings in each of their last three home games against NL Central opponents that held a winning record.

Total Runs Facts

• Each of the Nationals’ last four games as underdogs have gone OVER the total runs line.
• Each of the Cardinals’ last four night games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the Cardinals’ last five games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in three of the Nationals’ last four games.

Matchup/League Facts

• The Nationals rank 30th in the league for home runs allowed this season (19).
• The Nationals rank 30th in the league for hits allowed this season (91).
• The Cardinals rank 27th in the league for opponent batting average this season (.273).
• The Cardinals rank 26th in the league for ERA this season (4.94).

Cardinals vs Nationals Prediction 

Washington had a couple of chances to win games against the Dodgers in their last series, but their pitching staff was horrible and they ended up getting swept. The Nationals are 0-3 at home this year and they are starting Littell, who was decent against the Phillies in his first start. St. Louis is 1-2 on the road and they have won three of their last five games. The Cardinals are starting Pallante, who pitched very well in his first start. The Nationals are playing in extremely high scoring games right now and with their pitching staff in shambles, I like the over here.

David Racey's Pick: Over 8