Cardinals vs Mariners Prediction 9/8/2025 Today’s MLB Picks

In this article we will formulate a Cardinals vs Mariners prediction for this MLB game on Monday, September 8th at T-Mobile Park in Seattle, Washington. Let’s take a look at the prediction for this MLB matchup. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 72-72 this year after they won two out of three against San Francisco by scores of 2-8, 3-2, and 4-3. In their game three win, St. Louis scored four runs in the fifth inning, which was enough to get the close win. The Cardinals recorded eight hits in the game and they were led by Nootbaar, Herrera, and Gorman, who all had one RBI in the win. St. Louis started Gray, who allowed two hits and three earned runs over 5.1 innings for the win, while O’Brien picked up the save. 

Prior to that series, the Cardinals won two out of three against the Athletics and two out of three against the Reds. St. Louis has won four of their last five games and they are fourth in the NL Central standings. The St. Louis pitching staff has a 4.27 ERA with a 1.31 WHIP and a .259 opponent batting average, while their offense has scored 622 runs with a .246 batting average and a .315 on base percentage this season. Wilson Contreras has led St. Louis with 20 home runs, 78 RBIs, and four stolen bases, while Alec Burleson (IL) has added 16 home runs and 60 RBIs this year. The projected starting pitcher for St. Louis is Miles Mikolas, who is 7-10 with a 4.89 ERA and a 1.33 WHIP over 136.1 innings pitched this year. 

Seattle Mariners Betting Preview

The Seattle Mariners are 75-68 this season after they won two out of three against Atlanta by scores of 1-4, 10-2, and 18-2. In their game three win, Seattle scored the first 10 runs in the contest and cruised to the victory. The Mariners recorded 20 hits and they committed one error in the game, while they were led by Arozarena, Raleigh, Rodriguez, Suarez, and Polanco, who all had three RBIs in the win. Seattle started Castillo, who allowed four hits and one earned run over 6.0 innings for the win, while three pitchers combined to finish the final 3.0 innings. 

Prior to that series, the Mariners lost all three against the Rays and two out of three against the Guardians. Seattle has lost four of their last six games and they are currently second in the AL West standings. The Seattle pitching staff has a 4.01 ERA with a 1.26 WHIP and a .245 opponent batting average, while the offense has scored 667 runs with a .243 batting average and a .319 on base percentage this season. Cal Raleigh has led Seattle with 53 home runs and 113 RBIs, while Julio Rodriguez has added 30 home runs and 89 RBIs this year. The projected starting pitcher for Seattle is Bryan Woo, who is 12-7 with a 3.02 ERA and a 0.97 WHIP over 169.2 innings pitched this season. 

Why the Mariners will beat the Cardinals 

The Cardinals have lost seven of their last eight games against American League opponents that held a winning record.
The Mariners have won 11 of their last 13 games at T-Mobile Park.
The Cardinals have failed to cover the run line in 12 of their last 13 road games against AL West opponents following a win.
The favorites have covered the run line in three of the last four games between the Cardinals and Mariners.
The Cardinals have trailed after 5 innings in each of their last four games as road underdogs against American League opponents.

Total Runs Facts

Seven of the Mariners’ last eight night games against National League opponents have gone OVER the total runs line.
Each of the Cardinals’ last four night games as underdogs have gone UNDER the total runs line.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Mariners’ last eight games as home favorites against NL Central opponents.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Cardinals’ last six games.

Seattle Mariners Player Prop Facts

Cal Raleigh has hit a home run in each of the Mariners’ last two games.
Victor Robles has recorded at least one hit in 13 of his last 14 appearances.
Jorge Polanco has recorded a Double in three of the Mariners’ last four games against NL opponents at T-Mobile Park.
Cal Raleigh ranks 3rd amongst qualified players for Slugging Percentage (.581) this season.

St. Louis Cardinals Player Prop Facts

Miles Mikolas has recorded four or more strikeouts in three of his four previous appearances with his team as a road underdog against AL West opponents.
Alec Burleson has hit a home run in three of the Cardinals’ last five games as road underdogs against AL West opponents.
Alec Burleson has recorded at least one hit in each of his last nine road appearances against AL opponents.

Matchup/League Facts

The Mariners rank 29th in the league for triples this season (8).
The Mariners rank 28th in the league for strikeouts against this season (1273).
The Cardinals rank 3rd in the league for walks allowed this season (403).
The Cardinals rank 27th in the league for slugging percentage this season (.381).

Cardinals vs Mariners Prediction 

Seattle has played pretty poorly over the last two weeks, but they got the series win in Atlanta and only trail Houston by 2.5 games in the West. The Mariners are 41-27 at home this year, while the Cardinals are 31-38 on the road. St. Louis has won four of their last five games and they are starting Mikolas, who has allowed one earned run in back to back starts. Seattle is going with Woo, who has allowed two earned runs or fewer in three of his last four outings. I don’t trust Mikolas at all, so I like the Mariners -1.5 here.