Boston Red Sox vs Arizona Diamondbacks Prediction 9/5/2025 Today’s MLB Picks

In this article, we will formulate a Red Sox vs Diamondbacks Prediction for this MLB game on Friday, September 5th at the Chase Field in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 70-71 record this season and are sitting on the 4th place of the NL West. The Diamondbacks have a 36-33 home record and are 66-66 in over/under They are coming off a 2-0 home victory over the Rangers, and are 6-2 in their last 8 games. Under is 5-2-1 in their last 8 games and are playing the Twins and the Giants next.

The Diamondbacks have a .249 batting average this season, .322 OBP and .436 slugging percentage. Arizona’s pitching staff has a 4.45 ERA and 1.33 WHIP. Geraldo Perdomo leads the Diamondbacks with 146 hits, adding a team-high 88 RBI. Ketel Marte is the team’s best hitter with a .290 batting average. Corbin Carroll leads the team in home runs with 28.

Eduardo Rodriguez (L) is the projected starting pitcher for the Diamondbacks, and he has a 6-8 record, 5.40 ERA and 1.62 WHIP.

Boston Red Sox Preview

The Boston Red Sox have a 78-63 record this season and are sitting on the third place of the AL East. The Red Sox have a 34-35 road record and are 69-69 in over/under. They are coming off a 1-8 home defeat by the Guardians, which ended their previous three-game winning streak. They are 4-1 to the over in their last 5 games and are playing the Athletics and the Yankees next.

The Red Sox have a .254 batting average this season, .325 OBP and .426 slugging percentage. Boston’s pitching staff has a 3.73 ERA and 1.29 WHIP.  Jarren Duran leads the Red Sox with 140 hits, and he is the team’s best hitter, with a .260 batting average. Trevor Story leads the team in RBI, with 88, adding a team-high 23 home runs.

Payton Tolle (R) is the projected starting pitcher for the Red Sox, and he has a 0-0 record, 3.38 ERA and 0.94 WHIP.

Red Sox vs Diamondbacks Prediction

The Dbacks have won their last four head-to-head meetings against the Red Sox, but the Red Sox are 3-1 in their last 4 visits in Arizona. Under is 3-1 in their last 4 meetings in Arizona.

In this Red Sox vs Diamondbacks Prediction, the Red Sox are coming as -125 road favorites. I don’t trust either pitcher in the matchup, as Rodriguez has been terrible for the Dbacks, and even weaker at home, with a 5.69 home ERA. On the flip side, we have not seen enough of Payton Tolle and I certainly don’t trust him in a road start. Both teams have electrifying offenses, averaging 10 runs per game combined, and the Dbacks have one of the weakest bullpens in baseball. I expect runs in this game, so take the over 8.5.