Jul 20, 2026; Boston, Massachusetts, USA; Boston Red Sox shortstop Tsung-Che Cheng (39) throws the ball for an out against the Baltimore Orioles during the sixth inning at Fenway Park. Mandatory Credit: Eric Canha-Imagn Images
Eric Canha-Imagn Images

Baltimore Orioles vs Boston Red Sox Prediction 7/22/2026 Today’s MLB Picks

Pick details

MATCHUP Baltimore Orioles Boston Red Sox
Team Records 49-52 51-48
Spread +1.5 -171 -1.5 141
Moneyline +121 -147
Total Over 9 (-108) Under 9 (-112)
Where Fenway Park, Boston, Massachusetts
When Wednesday, July 22, 2026
Time 07:10 PM EDT
TV MLB.TV

The Baltimore Orioles and the Boston Red Sox will meet on Wednesday in the second game of a four‑game American League East series at Fenway Park in Boston, Massachusetts.

Baltimore Orioles Betting Preview

The Baltimore Orioles enter Wednesday’s contest with a 49–52 overall record (4th in the American League East) and a 21–27 mark on the road. The Orioles offense has been competitive to this point in the season. Through 101 games played in 2026, Baltimore has compiled 464 runs scored (12th in MLB), 153 doubles, a .238 team batting average and 120 home runs which ranks 14th in Major League Baseball.

The Orioles arrive at this game in above average form. Baltimore has won three of the team’s last four games played this season, including a 5-2 victory over the Houston Astros two days ago.

Baltimore will turn to right hander Dean Kremer in this contest. In five starts made this season, Kremer has compiled a 1–2 win‑loss record, a 4.15 ERA, a 1.12 WHIP and 29 strikeouts, while allowing 22 hits and 7 walks in 26 innings pitched. Kremer will look to build on his steady performance from the first half of the regular season in tomorrow’s matchup with the Boston Red Sox.

The Baltimore Orioles lineup features first baseman Pete Alonso and outfielder Taylor Ward. Pete Alonso leads the team with 21 home runs (16th in MLB), 17 doubles, 54 walks, 66 RBIs (9th in MLB) and an .807 OPS. Taylor Ward enters this contest with a .251 batting average, 7 home runs and a .734 OPS.                                                                                                   

Boston Red Sox Betting Preview

The Boston Red Sox enter Wednesday’s matchup with a 51–48 overall record (3rd in the American League East) and a 22–27 mark at home. Boston has played outstanding baseball recently, winning fourteen consecutive games, including a convincing 10–0 shutout win over the Tampa Bay Rays four days ago.

Boston will start left hander Jake Bennett in this game. In nine starts made this season, Bennett has compiled a 5–3 record, a 2.35 ERA, a 0.88 WHIP and 38 strikeouts, while allowing 38 hits and 9 walks in 53.2 innings pitched. Jake Bennett has pitched exceptionally well recently, allowing one or fewer earned runs in four of his last five starts made in 2026.

The Boston Red Sox lineup features outfielder Wilyer Abreu and first baseman Willson Contreras. Wilyer Abreu enters this contest with a .267 batting average, 15 home runs, 21 doubles, 50 RBIs and an .800 OPS. Wilson Contreras has compiled a .289 batting average, 22 home runs (10th in MLB), 17 doubles and 66 RBIs.                                                         

Why the Baltimore Orioles will win.

• Offensive advantage. Pete Alonso and Taylor Ward lead the Baltimore Orioles lineup.

• Starting pitching. In five starts made this season, Dean Kremer has compiled a 1–2 win‑loss record, a 4.15 ERA, a 1.12 WHIP and 29 strikeouts in 26 innings pitched.

• Current form. The Baltimore Orioles have won three of the team’s last four games.     

Why the Boston Red Sox will win.

• Home field edge. Boston has historically played competitive baseball at Fenway Park.

• Starting pitching. In nine starts made this season, Jake Bennett has compiled a 5–3 record, a 2.35 ERA, a 0.88 WHIP and 38 strikeouts in 53.2 innings pitched.

• Recent form. The Red Sox arrive at this contest on the heels of a 14-game winning streak.

Baltimore Orioles vs. Boston Red Sox Prediction

In my view, this matchup favors the Boston Red Sox. Why? The Red Sox arrive at this contest on a rather impressive 14-game winning streak. Additionally, Boston hurler Jake Bennett has pitched exceptionally well recently, allowing one or fewer earned runs in four of his last five starts made in 2026. The data clearly indicates that Boston is the side to be on in this one. I am backing the Boston Red Sox on the moneyline in this game.

Hans Geevers's Pick: Boston Red Sox ML

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