Apr 15, 2026; San Diego, California, USA; Seattle Mariners left fielder Randy Arozarena hits a single during the fifth inning against the San Diego Padres at Petco Park. All MLB players are wearing number 42 today to honor Jackie Robinson. Mandatory Credit: Denis Poroy-Imagn Images
Denis Poroy-Imagn Images

Athletics vs Seattle Mariners Prediction 4/22/2026 Today’s MLB Picks

Pick details

MATCHUP Oakland Athletics Seattle Mariners
Team Records 13-11 10-15
Where T-Mobile Park, Seattle, Washington
When Wednesday, April 22, 2026
Time 04:10 PM EDT
TV MLB.TV

The Athletics and the Seattle Mariners meet Wednesday in MLB action from T-Mobile Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Athletics vs. Seattle Mariners prediction.

Starting Pitching Matchup

The Athletics will send out Aaron Civale for the start here and Civale is 2-1 with a 3.54 ERA and 16 strikeouts this season. Logan Gilbert will get the start for the Mariners and is 1-3 with a 4.03 ERA and 32 strikeouts this season.

Athletics Recap

The Athletics come into this game looking to add on to their 5-2 win over the Mariners from Tuesday’s matchup to sit at 13-11 this season. After this series, the Athletics will head on the road for a series against the Texas Rangers.

A’s Pushing For Sweep

Going into Tuesday, Shea Langeliers has 27 hits with 4 doubles, 7 home runs and 13 RBIs while Tyler Soderstrom’s added 19 hits with 7 doubles, a triple, 2 home runs and 15 RBIs. Brent Rooker has 6 hits with 2 home runs and 8 RBIs while Max Muncy has also chipped in 20 hits with 5 doubles, 2 triples, 2 home runs and 7 RBIs this season. Jacob Wilson also has 25 hits with 3 doubles, 2 home runs and 10 RBIs this season.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to bounce back from their loss at the hands of the Athletics on Tuesday to sit at 10-15 this season. After this series, the Mariners will head on the road for a series against the St. Louis Cardinals.

Mariners Drop Back-To-Back Games

Entering Tuesday, Brendan Donovan has 17 hits with 3 doubles, 3 home runs and 8 RBIs while Luke Raley has 5 home runs and 13 RBIs this season. Cole Young’s added 20 hits with 2 doubles, a triple, 2 home runs and 11 RBIs and Cal Raleigh has 15 hits with 3 doubles, 3 home runs and 12 RBIs as well this season. Randy Arozarena has 24 hits with 5 doubles, 2 home runs and 9 RBIs as well on the year. Josh Naylor also has 15 hits with 2 home runs and 8 RBIs as well on the year. 

Athletics @ Seattle Mariners Betting Trends: April 22, 2026

  • Probable Starting Pitcher: Logan Gilbert      Record this season: 1-3      ERA: 4.03
  • Home Record: 1-2
  • Last 5 against Athletics: 2-1

Why the Seattle Mariners will win

  • The Athletics have lost each of their last six day games against the Mariners following a win.
  • The Mariners have won 11 of their last 12 day games against AL West opponents following a home loss.
  • The Athletics have failed to cover the run line in each of their last six day games against AL West opponents following a win.
  • The Mariners have covered the run line in each of their last four day games against AL West opponents.
  • The Mariners have led after 3 innings in each of their last four day games.
  • The Mariners have won the first inning in each of their last four day games.
  • The Mariners have led after 5 innings in each of their last seven day games at T-Mobile Park against AL West opponents.

  • Probable Starting Pitcher: Aaron Civale      Record this season: 2-1      ERA: 3.54
  • Road Record: 2-0
  • Last 5 against Mariners: 2-2

Why the Athletics will win

  • The Athletics have won each of their last seven games as road underdogs.
  • The Mariners have lost each of their last six Wednesday games as favorites against American League opponents.
  • The Athletics have covered the run line in each of their last seven road games.
  • The Mariners have failed to cover the run line in each of their last nine Wednesday day games.
  • The Mariners have trailed after 5 innings in each of their last seven Wednesday day games against AL West opponents that held a winning record.

Total Runs Facts

  • Seven of the Athletics’ last eight day games against AL West opponents have gone OVER the total runs line.
  • Six of the last eight games between the Athletics and Mariners have gone UNDER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Mariners’ last 11 home games.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Athletics’ last six road games against AL West opponents.

Seattle Mariners Player Prop Facts

  • Cal Raleigh has hit at least one home run in each of the Mariners’ last three games against the Athletics.
  • Logan Gilbert has recorded a win in three of his last four home appearances against the Athletics.
  • Logan Gilbert has recorded seven or more strikeouts in each of his last 11 home appearances against AL West opponents.
  • Julio Rodriguez has recorded at least one hit in each of the Mariners’ last 14 home games against AL West opponents.

Athletics Player Prop Facts

  • Shea Langeliers has hit a home run in three of the Athletics’ last four games against AL West opponents.
  • Shea Langeliers has recorded at least one hit in each of his last seven road appearances after playing the previous day.
  • Shea Langeliers ranks T4th in the league in Home Runs (8) this season.

Matchup/League Facts

  • The Mariners rank 1st in the league for walks allowed this season (60).
  • The Mariners rank 27th in the league for batting average this season (.219).
  • The Athletics rank 28th in the league for walks allowed this season (119).
  • The Athletics rank 25th in the league for strikeouts against this season (223).

Athletics vs. Seattle Mariners Prediction

I’m on the Athletics in this one. Gilbert has been solid at home over the course of his career, but I’m still having trouble trusting the Mariners offense at the plate this season. I’m not necessarily president of the Aaron Civale fan club, but I think he’s a capable option that can pitch well away from Sacramento like a lot of A’s pitchers have with this new ballpark. Give me the Athletics here.

Chris Ruffolo's Pick: Athletics +1.5

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