Arizona Diamondbacks vs San Francisco Giants Prediction 8/28/2026 Today’s MLB Picks

The Arizona Diamondbacks and the San Francisco Giants meet Friday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Diamondbacks vs. San Francisco Giants prediction.

Starting Pitching Matchup

The Arizona Diamondbacks did not have a starting pitcher announced at the time that this article was posted. The San Francisco Giants will send out Blade Tidwell for the start here and Tidwell is 0-0 with a 3.58 ERA and 27 strikeouts this season.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to bounce back from a 6-1 loss at the hands of the Giants on Thursday to fall to 71-64 on the year. After this series, the Diamondbacks will head home for a game against the Philadelphia Phillies.

Diamondbacks Have Two-Game Win Streak Snapped

Entering Thursday, Corbin Carroll has 121 hits including 28 doubles, 16 triples, 18 home runs and 58 RBIs. Ketel Marte has 117 hits with 23 doubles, 3 triples, 21 home runs and 67 RBIs and Geraldo Perdomo has 117 hits, with 18 doubles, 6 triples, 9 home runs and 46 RBIs as well this season. Nolan Arenado also has 103 hits with 20 doubles, 21 home runs and 65 RBIs and Gabriel Moreno has 113 hits with 28 doubles, 10 home runs and 65 RBIs this season. Ildemaro Vargas also has 99 hits with 18 doubles, 5 triples, 9 home runs and 63 RBIs.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to build on their win over Arizona from Thursday to sit at 55-79 on the year. After this series, the Giants will head on the road for a series against the Atlanta Braves.

Giants Win 3 Of Last 4

Going into Thursday, Willy Adames has 107 hits with 25 doubles, 21 home runs and 51 RBIs along with 139 strikeouts. Matt Chapman has 72 hits with 18 doubles, a triple, 7 home runs and 42 RBIs and Jung Hoo Lee has 133 hits with 27 doubles, 4 triples, 9 home runs and 47 RBIs. Rafael Devers also has 123 hits with 31 doubles, 29 home runs and 76 RBIs but also has 145 strikeouts this season.

Arizona Diamondbacks @ San Francisco Giants Betting Trends: August 28, 2026

• Probable Starting Pitcher: Blade Tidwell      Record this season: 0-0      ERA: 3.58
• Home Record: 0-0
• Last 5 against Diamondbacks: –

Why the San Francisco Giants will win

• The underdogs have won four of the Diamondbacks’ last five games at Oracle Park.
• The Diamondbacks have lost four of their last five games as favorites against NL West opponents.
• The Diamondbacks have failed to cover the run line in each of their last nine games as favorites against the Giants following a road loss.
• The Giants have covered the run line in 12 of their last 13 games as home underdogs against the Diamondbacks.
• The Diamondbacks have trailed after 3 innings in each of their last five road games.
• The Giants have led after 5 innings in each of their last six home games.
• The Giants have won the first inning in each of their last four games as underdogs.

• Probable Starting Pitcher: Kohl Drake      Record this season: 0-1      ERA: 5.40
• Road Record: 0-0
• Last 5 against Giants: –

Why the Arizona Diamondbacks will win

• The Diamondbacks have won each of their last six night games against NL opponents following a loss.
• The Giants have lost each of their last eight Friday night games against NL opponents.
• The Diamondbacks have covered the run line in each of their last eight night games against NL opponents following a loss.
• The Giants have failed to cover the run line each of their last six Friday night games against teams that held a winning record.
• The Diamondbacks have led after 3 innings in six of their last eight games at Oracle Park against opponents that held a losing record.
• The Giants have trailed after 5 innings in each of their last six Friday night games against opponents that held a winning record.
• The Diamondbacks have won the first inning in four of their last five games against NL West opponents.

Total Runs Facts

• Each of the Giants’ last four games as home underdogs have gone UNDER the total runs line.
• Six of the Diamondbacks’ last seven games as road favorites have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in nine of the last 10 night games between the Diamondbacks and Giants.
• There has been at least one run scored in the first inning in seven of the Diamondbacks’ last eight games as favorites.

San Francisco Giants Player Prop Facts

• Rafael Devers has hit a home run in four of the Giants’ last five home games.
• Drew Gilbert has recorded at least one hit in each of his last 11 home appearances against NL opponents.

Arizona Diamondbacks Player Prop Facts

• Gabriel Moreno has hit a home run in each of the Diamondbacks’ last two road games against NL opponents.
• Gabriel Moreno has recorded at least one hit in each of his last 13 road appearances against NL West opponents.
• Gabriel Moreno ranks 6th amongst qualified players for Batting Average (.303) this season.

Matchup/League Facts

• The Giants rank 30th in the league for walks this season (354).
• The Giants rank 1st in the league for home runs allowed this season (124).
• The Diamondbacks rank 1st in the league for triples this season (35).
• The Diamondbacks rank 2nd in the league for strikeouts against this season (975).

Arizona Diamondbacks vs. San Francisco Giants Prediction

I’m backing Arizona here. I still am not 100% sold on Tidwell’s game as he’s had control issues at times, and in August, the Diamondbacks have shown a lot of restraint and discipline at the plate with a high walk rate and low K rate. I think the Diamondbacks get to Tidwell here and continue their season-long dominance of San Francisco, despite Thursday’s loss. Give me Arizona.

Chris Ruffolo's Pick: Arizona -105