Arizona Diamondbacks vs San Diego Padres Prediction 9/25/2026 Today’s MLB Picks

The Arizona Diamondbacks and the San Diego Padres will meet Friday night in a National League West matchup at Petco Park in San Diego, California. Let’s take a look at this matchup from a betting perspective.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks enter Friday’s contest with an 85-74 overall record (3rd in the National League West) and a 40-38 mark on the road. The Diamondbacks arrive at this contest on the heels of a five-game winning streak, including a 7-2 victory over the Colorado Rockies earlier this week.

The Diamondbacks will turn to right hander Brandon Pfaadt in this game. In 18 starts made in 2026, Pfaadt has compiled a 7-3 win-loss record, a 3.72 ERA, a 1.17 WHIP and 87 strikeouts in 128.1 innings pitched. Brandon Pfaadt performed at a high level in his most recent outing, allowing one earned run while scattering four hits and one walk across 4.1 innings pitched in the Arizona Diamondbacks 5-3 defeat of the New York Yankees last week. Pfaadt will look to continue that success in Friday night’s matchup.

The Arizona Diamondbacks lineup features catcher Gabriel Moreno and second baseman Ketel Marte. Moreno has compiled a .306 batting average (4th in MLB), 15 home runs, 77 RBIs, and an .866 OPS. Marte has tallied a .249 batting average, 22 home runs, 74 RBIs and a .749 OPS.                                                                    

San Diego Padres Betting Preview

The San Diego Padres enter Friday’s contest with an 88-70 overall record (2nd in the National League West) and a 49-29 mark at home. The Padres offense has been rather average this season. San Diego has compiled 695 runs scored (18th in MLB), 229 doubles, 180 home runs and a .242 team batting average which ranks 16th in Major League Baseball.

The Padres arrive at this contest in good form, winning six of the team’s last seven games.

The Padres will start right hander Casey Mize in this contest. In 25 starts made this season, Mize has compiled a 6-9 win-loss record, a 3.96 ERA, a 1.19 WHIP and 109 strikeouts in 127.1 innings pitched. Casey Mize has struggled recently, allowing four earned runs or more in two of his last four starts made in 2026.

The San Diego Padres lineup features Fernando Tatis Jr. and Manny Machado. Tatis Jr. enters this contest with a .287 batting average (15th in MLB), 25 home runs, 81 RBIs and an .825 OPS. Manny Machado has tallied a team leading 29 home runs, 87 RBIs and a .713 OPS.                          

Why the Arizona Diamondbacks will win.

• Starting pitching. In 28 appearances made in 2026, Brandon Pfaadt has compiled a 7-3 win-loss record, a 3.72 ERA, a 1.17 WHIP and 87 strikeouts in 128.1 innings pitched.

• Current form. The Arizona Diamondbacks have won five consecutive games.

• Offensive firepower. Nolan Arenado has amassed 27 home runs and 78 RBIs this season.    

Why the San Diego Padres will win.

• Home field advantage. The San Diego Padres have played exceptional baseball at home, compiling a 49-29 win-loss record at Petco Park.

• Starting pitching. In 25 starts made in 2026, Casey Mize has compiled a 3.96 ERA, a 1.19 WHIP and 109 strikeouts in 127.1 innings pitched.

• Recent form. The San Diego Padres have won six of the team’s last seven games.  

Arizona Diamondbacks vs. San Diego Padres Prediction

In my view, this matchup favors the Arizona Diamondbacks. Why? Arizona starting pitcher Brandon Pfaadt performed at a high level in his most recent outing, allowing one earned run while scattering four hits and one walk across 4.1 innings pitched in the Arizona Diamondbacks 5-3 defeat of the New York Yankees last week. Conversely, San Diego hurler Casey Mize has struggled recently, allowing four earned runs or more in two of his last four starts made in 2026. With that said, Arizona is the side to be on in this contest. I am backing the Arizona Diamondbacks on the moneyline in this game.

Hans Geevers's Pick: Arizona Diamondbacks ML