St. Louis Cardinals vs Cincinnati Reds Prediction 4/30/25 MLB Picks

Recent betting trends and streaks involving the St. Louis Cardinals

Recent betting trends and streaks involving the Cincinnati Reds

Recent betting trends in games played between the Cardinals and Reds

A summary that ties it all together and produces a favorable betting outcome for the Cardinals vs Reds game

St. Louis Cardinals Betting Preview

St. Louis opened their campaign with a sweep versus the Minnesota Twins, then fell in a series versus the Los Angeles Angels, and faced a sweep by the Boston Red Sox. St. Louis fell in their next set versus the Pittsburgh Pirates, then got a set victory against Philadelphia. The Cardinals kept it going with a series victory versus the Houston Astros, then took a sweep by the Mets before a series loss against the Braves. After wins over the Brewers in their first two weekend games, on Sunday, St. Louis suffered a 7-1 loss and couldn’t complete the sweep. In the Monday matchup with the Reds, the Cards were out-hit 8-5 in a 3-1 defeat. 

In game two versus Cincinnati, St. Louis was rained out. That matchup will be made up as part of a doubleheader on Wednesday.

Starter for game one will be St. Louis’ Miles Mikolas. So far, over five games this year, Mikolas is 0-2 with a 5.70 ERA in 23.2 innings total. Mikolas is 64-66 with a 4.19 ERA in 215 career games (187 starts). As a starter for Wednesday’s game two, the Cardinals are rolling with Steven Matz. So far this year, Matz is 2-0 with a 1.80 ERA in eight games (one start). Over 201 games (171 starts) in his MLB career, Matz is 57-60 with a 4.24 ERA. 

Cincinnati Reds Betting Preview

Over on the Reds’ side, they started things off with three straight series losses versus the San Francisco Giants, the Texas Rangers, and the Milwaukee Brewers. Cincinnati would then win a series in the rematch with the Giants before a sweep over the Pirates. After another series loss against the Mariners, the Reds beat Baltimore in a series, then fell to the Marlins in two of three. Cincinnati then took out the Rockies in their first two installments of the weekend set. In the Sunday finale, the Reds kept rolling with 14 team hits and secured an 8-1 blowout victory. In Monday’s game, Cincinnati got a solo home run from Jose Trevino and 6.0 innings with one earned run from starter Nick Martinez. 

Brady Singer will start the Wednesday opener for Cincinnati. This year, Singer is 4-0 with a 3.62 ERA in five starts over 27.1 innings of work. Singer is 40-44 with a 4.26 ERA in 132 career games (129 starts) in the MLB. For Wednesday’s game two, we should be seeing Andrew Abbott if the initial penciled-in matchup holds. 

Why the Cincinnati Reds will win

• The Cardinals have lost eight of their last nine road games.
• The Reds have won seven of their last eight home games against NL Central opponents.
• The Reds have covered the run line in eight of their last nine home games against NL Central opponents.
• The Cardinals have failed to cover the run line in seven of their last eight games against NL Central opponents.
• The Reds have led after 3 innings in seven of their last nine games at Great American Ball Park against National League opponents that held a losing record.
• The Cardinals have trailed after 5 innings in four of their last five games against National League opponents that held a winning record.

Why the St. Louis Cardinals will win

• The Reds have lost eight of their last nine games on the first leg of a doubleheader.
• The Cardinals have won five of their last six day games against the Reds at Great American Ball Park following a road loss.
• The Reds have failed to cover the run line in five of their last six home games on the first leg of a doubleheader.
• The Cardinals have covered the run line in each of their last three road games on the first leg of a doubleheader.
• The Reds have lost the first inning in three of their last four games against opponents that held a winning record at Great American Ball Park.

Total Runs Facts

• Eight of the last nine games between the Cardinals and Reds at Great American Ball Park have gone UNDER the total runs line.
• Four of the Cardinals' last five games against NL Central opponents have gone UNDER the total runs line.
• The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Reds' last five day games against NL Central opponents.
• The 'Inning 1 UNDER 0.5 runs' market has hit in 10 of the Cardinals' last 11 Wednesday games against NL Central opponents.

Cardinals vs Reds Prediction 

I’m leaning toward the Reds in game one. Cincinnati should be in relatively good hands with Singer on the mound. He’s been pretty decent overall lately—outside of three earned in 4.1 innings on six hits and three walks versus Seattle on April 17, that is. In total over his last three starts, Singer is 2-0 with eight earned runs in 15.1 innings on 12 hits and six walks. Singer will need a bit of a boost from the bats and the pen, but shouldn’t have a ton of issues with the Cardinals hitters if he’s on point.

As for game two, I was initially thinking of siding with the Reds, but I’ll lean toward the Cardinals instead. Matz may be tough to crack in the starting role. Over his last three outings, Matz is 2-0 with 8.1 innings and one earned run combined. If he bags another good start, St. Louis will be set up well.