White Sox vs Twins Prediction 4/23/25 MLB Picks

In this article, we will formulate a White Sox vs Twins prediction for this MLB game on Wednesday, April 23rd at Target Field in Minneapolis, Minnesota. Let’s take a look at the prediction for this MLB matchup. 

Chicago White Sox Betting Preview

The Chicago White Sox are 5-18 this season after they lost game one in this series by a score of 4-2. Chicago led 1-0 in the second inning, but they allowed the next four runs in the loss. The White Sox recorded 10 hits and they committed two errors in the game, while they were led by Amaya and Maton, who both had one RBI in the loss. Chicago started Martin, who allowed three hits and zero earned runs over 5.0 innings in the loss, while Vasil pitched the final three innings. 

Prior to this series, the White Sox lost three out of four against the Red Sox and all three against the Athletics. Chicago has lost eight of their last nine games, and they are currently last in the AL Central standings. The Chicago pitching staff has a 4.26 ERA with a 1.35 WHIP and a .234 opponent batting average, while the offense has scored 72 runs with a .201 batting average and a .274 on-base percentage this season. Andrew Benintendi has led Chicago with four home runs and eight RBIs, while Andrew Vaughn has added three home runs and 10 RBIs this year. The projected starting pitcher for Chicago is TBD.

Minnesota Twins Betting Preview

The Minnesota Twins are 8-15 this year after they won game one in this series by a score of 4-2 on Tuesday night. Minnesota led 2-1 in the later innings, and they added two more runs in the eighth, which ended up being the difference in the win. The Twins recorded five hits in the game, and they were led by Larnach, who went 2-3 with one home run, two RBIs, and one walk in the win. Minnesota started Ober, who allowed eight hits and one earned run over 6.0 innings for the win, while Duran allowed a run in the ninth, but still got the save. 

Prior to this series, the Twins lost all three against the Braves, but did win two out of three against the Mets before that. Minnesota has lost three of its last four games, and they are currently fourth in the AL Central standings. The Minnesota pitching staff has a 3.93 ERA with a 1.24 WHIP and a .245 opponent batting average, while their offense has scored 79 runs with a .210 batting average and a .284 on-base percentage this season. Harrison Bader has led Minnesota with three home runs and 12 RBIs, while Byron Buxton has added four home runs and 10 RBIs this year. The projected starting pitcher for Minnesota is David Festa, who is 0-0 with a 0.00 ERA and a 1.11 WHIP over 9.0 innings pitched this season. 

Why the Twins will beat the White Sox 

• The White Sox have lost each of their last 13 games at Target Field.
• The Twins have won each of their last nine home games against the White Sox following a win.
• The White Sox have failed to cover the run line in 12 of their last 13 games at Target Field against American League opponents that held a losing record.
• The favorites have covered the run line in each of the last six games between the White Sox and Twins at Target Field.
• The Twins have led after 5 innings in each of their last five home games against AL Central opponents that held a losing record.
• The White Sox have trailed after 3 innings in each of their last four games at Target Field.

Total Runs Facts

• Seven of the Twins’ last eight games against American League opponents have gone UNDER the total runs line.
• Four of the White Sox’s last five games against AL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Twins’ last four night games against AL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the White Sox’s last five night games against AL Central opponents.

Minnesota Twins Player Prop Facts

• Jonah Bride has recorded at least one hit in each of his last 10 appearances against AL opponents.
• Trevor Larnach has scored at least one run in each of his last six appearances against the White Sox at Target Field.
• Willi Castro has recorded at least one Single in each of his last four appearances against the White Sox at Target Field.
• Trevor Larnach has hit a home run in three of his last five appearances in night games against AL Central teams that held a losing record.
• Willi Castro has recorded at least one RBI in eight of his last nine appearances against the White Sox at Target Field.
• Jose Miranda has recorded at least one Double in three of his last four appearances at Target Field against AL Central opponents that held a losing record.

Chicago White Sox Player Prop Facts

• Andrew Benintendi has hit a home run in three of his last eight appearances against the Twins after playing the previous day.
• Andrew Benintendi has recorded a Single in each of his last four road appearances against opponents that held a losing record.
• Andrew Vaughn has recorded at least one hit in each of his last six appearances against the Twins after playing the previous day.
• Mike Tauchman has recorded at least one RBI in each of his three previous appearances against the Twins at Target Field.
• Mike Tauchman has scored at least one run in each of his three previous appearances at Target Field.

White Sox vs Twins Prediction 

Minnesota didn’t generate many hits on Tuesday night, but they were able to score four runs and get a much-needed win. The Twins are 5-5 at home this year, while the White Sox are 1-10 on the road. Chicago has just five wins on the season, and they have scored three runs or fewer in four of their last five games. The White Sox will be going against Festa, who has allowed zero earned runs over nine innings of work so far this year. I really like how Festa pitched against the Mets last time out, and he should have no issues with this White Sox lineup. Take Minnesota -1.5 here.