Seattle Mariners vs Boston Red Sox Prediction 4/23/25 MLB Picks

In this article, we will formulate a Mariners vs Red Sox prediction for this MLB game on Wednesday, April 23, at Fenway Park in Boston, Massachusetts. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Betting Preview

The Seattle Mariners (12-11, 4-6 Away) opened their three-series road trip with wins over the Cincinnati Reds and Toronto Blue Jays. After winning four out of five games, the Mariners lost the opener of this series against the Red Sox. J.P. Crawford led the offense with two RBI in an 8-3 defeat, while Bryce Miller took the loss after allowing four runs on five hits with four strikeouts and four walks in 4.2 innings.

This season, the Mariners average 4.45 runs per game (13th in the MLB) on a .224/.320/.394slash line. Regarding pitching, the Mariners’ staff has a 3.76 ERA (12th) and 1.34 WHIP (21st). Randy Arozarena leads the Mariners with a .193 batting average, four home runs, and 17 RBI this season.

The projected starting pitcher for the Mariners is Emerson Hancock, who is 0-1 in two starts this season, with a 12.71 ERA and 2.29 WHIP in 5.2 innings.

Boston Red Sox Betting Preview

The Boston Red Sox (14-11, 8-4 Home) are looking to win their third consecutive series after defeating the Tampa Bay Rays and Chicago White Sox. The Red Sox are going through their best period of the season as they have won six of the previous seven games. In Game 1 of the current series against the Mariners, Alex Bregman and Triston Casas led the team with three RBI apiece, while Brayan Bello got the win after allowing one run on four hits with three strikeouts and three walks over 5.0 innings of work.

This year, the Red Sox average 4.50 runs per game (12th in the MLB) on a .246/.326/.394 triple-slash. When it comes to pitching, the Red Sox’s staff has a 4.03 ERA (14th) and 1.27 WHIP (16th). Alex Bregman leads the Red Sox with a .302 batting average, four home runs, and 19 RBI this season.

Sean Newcomb will take the mound for the Red Sox on Wednesday. The 31-year-old left-hander has a 0-2 record in four starts this year with a 3.63 ERA and 1.90 WHIP in 17.1 innings.

Why the Red Sox will beat the Mariners

• The Mariners have lost eight of their last nine night games against AL East opponents that held a winning record.
• The Red Sox have won each of their last seven games as home favorites against the Mariners.
• The Red Sox have covered the run line in eight of their last nine night games against the Mariners following a win.
• The Mariners have failed to cover the run line in five of their last six games at Fenway Park.
• The Mariners have trailed after 5 innings in each of their last eight Wednesday night games against American League opponents that held a winning record.
• The Red Sox have led after 3 innings in eight of their last nine night games against AL West opponents that held a winning record.

Total Runs Facts

• Ten of the last 11 games between the Mariners and Red Sox at Fenway Park have gone OVER the total runs line.
• Five of the Mariners’ last six games as underdogs have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Mariners’ last eight road games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Red Sox’s last five games.

Matchup/League Facts

• The Red Sox rank T3rd in the league for hits this season (214).
• The Red Sox rank T4th in the league for steals this season (29).
• The Mariners rank 3rd in the league for steals this season (32).
• The Mariners rank T4th in the league for walks this season (98).

Mariners vs Red Sox Prediction

The Red Sox have won six of the previous ten H2H encounters, including four of the last five. Because of the pitching matchup, I am backing the Red Sox to win again on Wednesday. Hancock is a rather inexperienced major league pitcher and could struggle at Fenway Park, while Sean Newcomb has a favorable matchup against Seattle, which has a .212 BA in 217 at-bats against southpaws this season. Newcomb didn’t allow a single hit in 14 at-bats against the Mariners so far in his career. Back the Red Sox.