Arizona Diamondbacks vs Miami Marlins Prediction 4/16/25 MLB Picks

Recent betting trends and streaks involving the Arizona Diamondbacks

Recent betting trends and streaks involving the Miami Marlins

Recent betting trends in games played between the Diamondbacks and Marlins

A summary that ties it all together and produces a favorable betting outcome for the Diamondbacks vs Marlins game

Arizona Diamondbacks Betting Preview

Arizona halved a four-game series against the Chicago Cubs in their opening series of 2025, then took two of three games against the New York Yankees in the next set. Arizona then lost two of three against the Washington Nationals before winning a three-game series against the Orioles. Following a 7-0 loss to the Milwaukee Brewers on Friday, the Diamondbacks came back for a 5-4 win in game two. Arizona scored all five in the bottom of the ninth during that miraculous victory. On Sunday, the Diamondbacks managed all of their runs during their final four innings in a 5-2 comeback win.

In the Tuesday opener versus the Marlins, Arizona scored four runs in the second inning and five more in the sixth during a 10-4 victory. The Diamondbacks got a home run, two runs, two hits, and five RBI from Corbin Carroll. Geraldo Perdomo and Josh Naylor each had a home run as well. 

Brandon Pfaadt will take the mound for the starting role on Wednesday for Arizona. This year, over his three starts, Pfaadt is 2-1 with a 3.50 ERA in 18.0 innings. In his career, Pfaadt is 16-20 with a 4.96 ERA in 54 games (53 starts). 

Miami Marlins Betting Preview

Over on the Marlins’ side, they managed to win three of four games versus the Pittsburgh Pirates in their opening series this year. Miami would continue with a series loss versus the New York Mets, and then a two-game split versus the Braves. The Marlins would lose two of three during their rematch with the Mets last week, then they split the first pair in the weekend series against the Washington Nationals. Miami ended up winning the series with an 11-4 Sunday victory. 

On Tuesday, the Marlins showed some life in a couple of innings but couldn’t close the gap in the end. Miami’s Xavier Edwards came up with two hits and one RBI. Griffin Conine added two hits with two runs, and starter Connor Gillispie lasted 5.0 innings with eight earned on eight this and two walks. 

It’ll be Max Meyer in the starter role for the Marlins on Wednesday. This year, Meyer is 1-1 over three starts, posting a 2.00 ERA in 18.0 innings. Meyer is 4-7 with a 5.00 ERA in 16 career starts in the MLB. 

Why the Miami Marlins will win

• The Marlins have won seven of their last eight night games following a loss.
• The Diamondbacks have lost five of their last seven games as favorites against National League opponents following a win.
• The Marlins have covered the run line in each of their last four games as home underdogs against National League opponents following a home loss.
• The Diamondbacks have failed to cover the run line in six of their last eight games as favorites against NL East opponents following a road win.

Why the Arizona Diamondbacks will win

• The Diamondbacks have won each of their last nine Wednesday games against National League opponents.
• The Marlins have lost each of their last six games against the Diamondbacks following a home loss.
• The Diamondbacks have covered the run line in each of their last 11 Wednesday games.
• The Marlins have failed to cover the run line in each of their last six games against the Diamondbacks following a home loss.
• The Marlins have trailed after 3 innings in six of their last seven home games against NL West opponents that held a winning record.
• The Diamondbacks have led after 5 innings in four of their last five games against the Marlins at LoanDepot Park.

Total Runs Facts

• Each of the Marlins' last five games against NL West opponents have gone OVER the total runs line.
• Each of the Diamondbacks' last five night games against NL East opponents have gone OVER the total runs line.
• The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Marlins' last five games against National League opponents.
• The 'Inning 1 OVER 0.5 runs' market has hit in five of the Diamondbacks' last six games as road favorites against NL East opponents.

Diamondbacks vs Marlins Prediction 

I’ll stick with the Marlins in this one. Meyer has one shaky start in the books this year, along with two solid outings. In the shaky one, Meyer still went 6.0 innings with three earned runs on eight hits and two walks. In the other two combined, Meyer is 1-0 with one earned run in 12.0 total innings. As for Pfaadt, he posted seven earned runs in 12.0 innings on 12 hits and one walk over his first two starts. Pfaadt followed that up with a win over Baltimore, notching 6.0 clean frames, four hits, and two walks. 

On Tuesday, Miami had a pretty good offensive night, but the couple of bad innings really did them in. After Gillispie’s eight earned in 5.0 innings, George Soriano followed up with 3.0 innings with two more earned runs. Meyer will need to get the team off to a better start on Wednesday.