Oct 20, 2026; San Antonio, Texas, USA;  Oklahoma City Thunder guard Shai Gilgeous-Alexander (2) looks on in the second half against the San Antonio Spurs at Frost Bank Center.  Mandatory Credit: Daniel Dunn-Imagn Images
IMAGN IMAGES via Reuters Connect

Nuggets vs Thunder Prediction 10/22/2026 Today’s NBA Picks

Pick details

Denver vs Oklahoma City Odds and Matchup Info
MATCHUP Denver Nuggets Oklahoma City Thunder
Team Records 0-0 1-0
Spread +8.5 -110 -8.5 -110
Moneyline +270 -340
Total Over 235.5 (-110) Under 235.5 (-110)
Where Paycom Center, Oklahoma City, OK
When Thursday, October 22, 2026
Time 09:30 PM EDT
TV ESPN

The Nuggets and Thunder meet Thursday in NBA action at the Paycom Center. Here’s a Nuggets vs Thunder Prediction. This article will include a Nuggets vs Thunder Pick.

Nuggets Betting Preview

The Nuggets have made the playoffs in each of the last eight years and enter year three under coach David Adelman. The Nuggets haven’t gone two straight seasons without a playoff win since the 2012-13 season.

The Nuggets added DeMar DeRozan while watching Peyton Watson and Tim Hardaway Jr. leave. The core of Nikola Jokic, Aaron Gordon, and Jamal Murray returns. The Nuggets have a puncher’s chance every night due to having the best player in the league, but legit success comes down to depth and health. Murray and Gordon have to avoid injury. Guys like Cameron Johnson, DeRozan, and Tyus Jones have to contribute consistently. The Nuggets are a 50-win team on paper, but getting back to title aspirations will take work.

Thunder Betting Preview

The Oklahoma City Thunder beat the Spurs, and they play the Clippers and Suns next. The Thunder have won 20 of their last 23 regular season games.

The Oklahoma City Thunder are averaging 116 points on 45.3 percent shooting and allowing 104 points on 38.7 percent shooting. Shai Gilgeous-Alexander is averaging 32 points and 4 assists, while Jared McCain is averaging 20 points and 2 rebounds. Chet Holmgren is the third double-digit scorer, and Jalen Williams is grabbing 7 rebounds. The Oklahoma City Thunder are shooting 45.2 percent from beyond the arc and 80 percent from the free-throw line. The Oklahoma City Thunder are allowing 27 percent shooting from deep and are grabbing 47 rebounds per game.

Nuggets vs Thunder Injury Report

The Thunder will be without Otega Oweh, Thomas Sorber, and Nikola Topic.

The Nuggets will be without Julian Strawther. Spencer Jones is questionable with a hamstring issue.

Nuggets vs Thunder Prediction

I considered the Nuggets, and the points and the underdog have covered 6 of the last 9 games between these teams. However, I value teams that have a game under their belt over teams that don’t. OKC has had a chance to get its feet under it while the Nuggets will be ironing out the wrinkles on the road. Not a great spot for a Nuggets team that lost some depth and will be asking more from its veteran core. The Thunder have also been covering machines for NBA bettors over the last two or three regular seasons and already cashed a nice underdog ticket one game through the season. Give me OKC and the chalk.

Randy Chambers's Pick: Oklahoma City -8.5

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