Chicago Cubs vs San Diego Padres Prediction 4/16/25 MLB Picks

Cubs Looking For Another Series Win

Kyle Tucker leads the Cubs with 25 hits, including team-highs of 8 doubles, 5 home runs, and 18 RBIs, while Seiya Suzuki also has 19 hits with a pair of doubles and 4 home runs and 15 RBIs of his own. Miguel Amaya added 6 doubles and 8 RBIs, and Pete Crow-Armstrong also has contributed 6 doubles this season. Dansby Swanson has added 4 home runs and 12 RBIs. Suzuki also has the unfortunate distinction of leading the Cubs with 23 strikeouts so far this season. Crow-Armstrong also has a team-high 7 stolen bases, while Nico Hoerner has 6 stolen bases this season.

Why the Chicago Cubs will win

• The Cubs have won four of their last five games as underdogs after playing the previous day.
• The Padres have lost 12 of their last 18 games as home favorites following an extra-innings loss.
• The Cubs have covered the run line each of their last six Wednesday day games against NL West opponents that held a winning record.
• The Padres have failed to cover the run line in five of their last six day games against National League opponents that held a winning record.

Chicago Cubs Player Prop Facts

• Nico Hoerner has recorded an RBI in each of the Cubs' last five day games against NL West opponents that held a winning record.
• Matthew Boyd has recorded a win in three of his last four appearances with his team as a road underdog against NL opponents.
• Justin Turner has scored a run in each of his last five appearances with his team as an underdog against the Padres.
• Matthew Boyd has recorded five or more strikeouts in each of his last seven appearances against NL opponents.
• Nico Hoerner has recorded at least one Single in nine of his last 10 appearances after playing the previous day.
• Kyle Tucker has recorded at least one hit in 14 of his last 15 road appearances against NL opponents that held a winning record.
• Seiya Suzuki has hit at least one home run in three of his last six road appearances.
• Kyle Tucker ranks T2nd in the league in Hits (25) this season.

San Diego Padres Recap

The San Diego Padres will try to bounce back and win the series after their loss in Tuesday’s matchup to drop to 14-4 on the year. After this series, the Padres will head on the road for an interleague series against the Houston Astros.

Padres Have Five-Game Win Streak Snapped

Manny Machado has 21 hits, including a team-high 7 doubles and 6 stolen bases, while Fernando Tatis Jr. has 23 hits with a team-high 6 home runs and 12 RBIs, along with 6 stolen bases of his own this season. Luis Arraez has added 21 hits with 3 doubles, while Jackson Merrill’s added 14 hits with 3 home runs and 10 RBIs as well. Xander Bogaerts also has 5 doubles and 4 stolen bases this season.

Why the San Diego Padres will win

• The Padres have won each of their last nine games as home favorites.
• The Cubs have lost each of their last six games at Petco Park following a win.
• The Padres have covered the run line in each of their last 10 games at Petco Park.
• The Cubs have failed to cover the run line in seven of their last eight road games following an extra innings win.

San Diego Padres Player Prop Facts

• Luis Arraez has recorded at least one Double in three of the Padres' last four games as favorites against NL Central opponents.
• Fernando Tatis Jr. has hit at least one home run in three of the Padres' last four games as favorites.
• Fernando Tatis Jr. has recorded at least one RBI in five of the Padres' last six games as favorites against NL opponents.
• Nick Pivetta has recorded a win in three of his last four home appearances.
• Manny Machado has scored at least one run in seven of the Padres' last eight games as favorites.
• Jose Iglesias has recorded at least one Single in each of his last 11 appearances in day games against teams that held a winning record.
• Nick Pivetta has recorded six or more strikeouts in seven of his last eight appearances with his team as a home favorite.
• Fernando Tatis Jr. has recorded at least one hit in each of the Padres' last 14 games as favorites against NL opponents.
• Fernando Tatis Jr. ranks T2nd in the league in Home Runs (6) this season.

Total Runs Facts

• Each of the Padres' last six day games as favorites have gone UNDER the total runs line.
• Each of the Cubs' last five games after going to extra innings have gone UNDER the total runs line.

Chicago Cubs vs. San Diego Padres Prediction

I’m on the under in this one. We saw a low-scoring game on Tuesday, and I think we could end up seeing another here as Boyd’s been really solid early on this season, and Pivetta has been at his best at Petco Park so far this season, which is a pitcher-friendly ballpark to begin with. I think we could see a pitcher’s duel in this one, so I’m going to roll with the under in this game.