Minnesota Twins vs Chicago White Sox Prediction 4/1/25 MLB Picks

Chicago White Sox Betting Preview

The Chicago White Sox are 2-2 this year after they won game one by a score of 9-0 on Monday. Chicago scored three runs in the first, four in the second, and two in the third, and they were able to cruise to an easy victory behind a great pitching performance from Martin Perez. The White Sox recorded eight hits and committed one error in the win, and they were led by Benintendi and Vaughn, who both had one home run and three RBIs. Chicago started Martin Perez, who allowed zero earned runs and had nine strikeouts in 6.0 innings of work for the win. 

Prior to that win, the White Sox lost two out of three games against the Angels by scores of 8-1, 0-1, and 2-3. The Chicago pitching staff has a 0.75 ERA with a 0.92 WHIP and a .169 opponent batting average, while their offense has scored 19 runs with a .210 batting average and a .283 on-base percentage this year. Andrew Benintendi has led Chicago with two home runs and six RBIs, while Andrew Vaughn has added one home run and three RBIs. The projected starting pitcher for Chicago is Shane Smith, who is making his MLB debut here. The White Sox will meet the Tigers after this series.

Why the White Sox will beat the Twins 

• The Twins have lost each of their last seven games as favorites following a loss.
• The White Sox have won five of their last six games as home underdogs after playing the previous day.
• The White Sox have covered the run line in each of their last nine home games.
• The Twins have failed to cover the run line in each of their last eight games as favorites.
• The White Sox have led after 3 innings in each of their last three games against AL Central opponents.
• The Twins have lost the first inning in three of their last four road games.
• The White Sox have led after 5 innings in each of their last three games against the Twins at Rate Field.

Total Runs Facts

• Six of the Twins' last seven games after playing the previous day have gone OVER the total runs line.
• Five of the White Sox's last six night games as underdogs have gone UNDER the total runs line.
• The 'Inning 1 OVER 0.5 runs' market has hit in 10 of the White Sox's last 11 games as home underdogs against AL Central opponents.
• The 'Inning 1 OVER 0.5 runs' market has hit in each of the Twins' last four road games.

Chicago White Sox Player Prop Facts

• Andrew Vaughn has recorded two or more RBIs in each of the White Sox's last four home games against AL Central opponents that held a losing record.
• Andrew Benintendi has hit a home run in each of his last two appearances against AL Central opponents.
• Andrew Benintendi has recorded at least one hit in each of his last nine appearances at Rate Field against opponents that held a losing record.
• Austin Slater has recorded at least one Single in each of his last six home appearances against AL Central opponents that held a losing record.
• Andrew Benintendi has scored a run in each of his last four home appearances against AL Central opponents that held a losing record.

Minnesota Twins Player Prop Facts

• Trevor Larnach has recorded two hits in four of his last five appearances in night games.
• Willi Castro has recorded at least one Single in each of the Twins' last four games against the White Sox.
• Trevor Larnach has scored at least one run in nine of his last 10 appearances with the Twins as favorites against the White Sox.
• Willi Castro has recorded an RBI in four of the Twins' last five games as road favorites.
• Byron Buxton has hit at least one home run in 11 of his last 32 appearances against the White Sox.
• Willi Castro has recorded a Double in three of the Twins' last four road games.

Minnesota Twins vs Chicago White Sox Prediction 

Chicago marches into this matchup after a dominating win on Monday, and they have the best pitching staff in the MLB through four games. The White Sox have allowed a total of five runs so far this season, which has covered up for some poor hitting. Minnesota is searching for their first win of the season, and they have scored a total of three runs in their last three games. The Twins will send Woods Richardson to the mound in this game, who was a decent option in 2024, while Shane Smith is making his first appearance in the MLB for Chicago. I think Minnesota is probably the better option in this game, especially against a rookie, but I can’t back their offense with how they are hitting. Take the White Sox and the plus money at home.