Virginia Tech vs SMU Prediction 11/6/2026 Today’s College Football Picks

The Virginia Tech Hokies and the SMU Mustangs meet in week 10 college football action from Gerald J. Ford Stadium on Friday. We will look at this from a betting perspective and determine the best bets for this game. 

Virginia Tech Hokies vs. SMU Mustangs Prediction

I’m on Virginia Tech and the points here. I just think this is simply a case of too many points in this one, as SMU is a solid team at home but both teams are still in the mix to make the ACC title game. Virginia Tech’s road schedule this season hasn’t had the toughest tests, but I think that this Hokie team keeps it close at the very least, so give me Virginia Tech and the points here.

Virginia Tech Hokies Recap

The Virginia Tech Hokies come into this game looking to add on to their 20-16 win over Clemson last time out to sit at 6-2 this season. After this game, Virginia Tech will head home for a game against Stanford. Ethan Grunkemeyer has thrown for 2,140 yards, 17 touchdowns, and 2 interceptions while completing 71.4% of his passes to lead the Virginia Tech passing attack, backed by 187 completions on 262 attempts, with Bryce Baker providing supplemental support via 127 passing yards and 1 score on 11 completions, and Luke Reynolds adding 8 passing yards on 1 completion. The Hokies’ ground game is spearheaded by Jeffrey Overton Jr., who rushes for 639 yards and 4 touchdowns on 113 carries, followed closely by Marcellous Hawkins Jr. with 337 yards and 5 scores on 85 carries, Que’Sean Brown adding 34 rushing yards on 3 attempts, Messiah Mickens chipping in 34 yards on 8 carries, and Darius Taylor adding 22 yards on 5 rushing attempts. Through the air, Que’Sean Brown leads the receiving corps with 685 yards and 3 touchdowns on 51 catches, while Luke Reynolds adds 493 yards and 6 scores on 50 receptions, Ayden Greene logs 294 yards and 2 scores on 17 receptions, Jeffrey Overton Jr. adds 214 yards and 2 scores on 23 receptions, and Davion Brown rounds out key targets with 184 yards and 1 score on 13 receptions. Defensively, Keon Wylie anchors the Virginia Tech squad by logging a team-high 41 total tackles. Altogether, the Hokies’ defensive unit has successfully combined to bring down opposing quarterbacks for 24 sacks, 145 yards lost, and 18 pass deflections while also coming away with 2 total interceptions.

Why the Virginia Tech Hokies will win

• The underdog has won three of Virginia Tech’s last four games.
• The underdog has covered the spread in four of Virginia Tech’s last five games.
• Virginia Tech has won the first half in each of its last eight games.
• Virginia Tech has won the first quarter in six of its last eight games.

SMU Mustangs Recap

The SMU Mustangs come into this game looking to bounce back from their 30-27 loss at the hands of Syracuse last time out to sit at 6-2 this season. After this game, SMU will head home for a game against Wake Forest. Kevin Jennings has thrown for 2,414 yards, 21 touchdowns, and 5 interceptions while completing 73.7% of his passes to lead the SMU passing attack, backed by 185 completions on 251 attempts, with Ty Hawkins providing supplemental support via 117 passing yards and 2 scores on 12 completions. The Mustangs’ ground game is spearheaded by Kendrick Raphael, who rushes for 692 yards and 9 touchdowns on 135 carries, followed closely by Kevin Jennings with 115 yards and 2 scores on 56 carries, Dramekco Green adding 111 rushing yards on 36 attempts, Derrick McFall chipping in 87 yards on 15 carries, and Ty Hawkins adding 75 yards on 6 rushing attempts. Through the air, Yamir Knight leads the receiving corps with 523 yards and 3 touchdowns on 44 catches, while Yannick Smith adds 437 yards and 2 scores on 27 receptions, Jalen Cooper logs 389 yards and 1 score on 27 catches, Jalen Hale adds 258 yards and 3 scores on 16 receptions, and Randy Pittman Jr. rounds out key targets with 214 yards and 4 scores on 23 catches. Defensively, Alexander Kilgore anchors the SMU squad by logging a team-high 41 total tackles. Altogether, the Mustangs’ defensive unit has successfully combined to bring down opposing quarterbacks for 14 sacks, 130 yards lost, and 23 pass deflections while also coming away with 2 total interceptions.

Why the SMU Mustangs will win

• SMU has won each of its last 17 games against conference opponents at Gerald J. Ford Stadium.
• Virginia Tech has lost seven of its last eight games in November.
• Virginia Tech has failed to cover the spread in each of its last four road games in November.
• SMU has covered the spread in six of its last seven home games in November.
• SMU has won the first half in 22 of its last 23 games as a favorite in Texas.
• SMU has won the first quarter in each of its last seven November games against non-AP-ranked teams.

Chris Ruffolo's Pick: Virginia Tech +6.5