Syracuse vs Virginia Prediction 10/10/2026 Today’s College Football Picks

The Syracuse Orange and the Virginia Cavaliers meet in week 6 college football action from the Scott Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Syracuse Orange vs. Virginia Cavaliers Prediction.

Syracuse Orange Recap

The Syracuse Orange come into this game looking to build on their 42-41 win over UConn last time out to sit at 2-2 this season. After this game, Syracuse will head home for a game against Louisville.

Orange Snap Two-Game Slide

Steve Angeli has thrown for 731 yards, 4 touchdowns and 5 interceptions on 54.8% passing while Tylik Hill leads Syracuse in rushing with 287 yards and a touchdown through 5 games this season. Shavane Anderson Jr. sits behind Hill on the ground with 146 yards and 3 touchdowns. Umari Hatcher leads the Orange in receiving with 434 yards and 29 catches along with 5 touchdowns, while Justus Ross-Simmons trails with 161 yards and 10 catches. On defense, Chris D’Appolonia has a team-high 26 tackles while Syracuse’s defense as a whole has combined for 11 sacks and 2 interceptions through 5 games this season.

Virginia Cavaliers Recap

The Virginia Cavaliers come into this game looking to bounce back from a 38-7 loss at the hands of Florida State last time out to sit at 3-2 this season. After this game, Virginia will head on the road for a game against SMU.

Cavaliers Alternate Wins & Losses In 4 Straight

Beau Pribula has thrown for 961 yards, 12 touchdowns and an interception on 67.8% passing while Jekail Middlebrook leads Virginia in rushing with 242 yards and a touchdown through 5 games this season. Xavier Brown sits behind Middlebrook on the ground with 166 yards and 2 touchdowns. Kameron Courtney leads the Cavaliers in receiving with 166 yards and 15 catches along with 2 touchdowns, while Rico Flores Jr. trails with 152 yards and 11 catches. On defense, Jacobie Henderson has a team-high 26 tackles while Virginia’s defense as a whole has combined for 11 sacks and 8 interceptions through 5 games this season.

Syracuse Orange @ Virginia Cavaliers Betting Trends: Week 6

Why the Virginia Cavaliers will win

• Syracuse has lost each of its last nine games against conference opponents.
• Virginia has won nine of its last 10 games at Scott Stadium.
• Virginia has covered the spread in each of its last four games at Scott Stadium.
• Syracuse has failed to cover the spread in each of its last four games in October.
• Virginia has won the first quarter in 10 of its last 11 games against non-AP-ranked teams.
• Syracuse has lost the first half in each of its last 13 October games as an underdog against non-AP-ranked teams.

Why the Syracuse Orange will win

• Syracuse has won three of its last four games as an underdog against teams from Virginia.
• Virginia has failed to cover the spread in each of its last four October games as a favorite.
• Syracuse has covered the spread in three of its last four games as an underdog against teams from Virginia.
• Virginia has lost the first half in four of its last five October games as a favorite.

Total Points Facts

• Each of Virginia’s last seven October games against non-AP-ranked teams have gone UNDER the total points line.
• Each of Syracuse’s last five games as an underdog against non-AP-ranked teams have gone UNDER the total points line.

Virginia Cavaliers Player Prop Facts

• Heading into Week 6, Brandyn Hillman ranks T2nd amongst FBS players for interceptions (3) this season.

Syracuse Orange Player Prop Facts

• Heading into Week 6, Umari Hatcher ranks T11th amongst FBS players for receiving touchdowns (5) this season.

Matchup/League Facts

• Virginia ranks 3rd among FBS teams for sacks this season (20.0).
• Virginia ranks T4th among FBS teams for average point differential in first quarters this season (+10.4).
• Syracuse ranks 5th among FBS teams for Q2 points per game this season (16.8).
• Syracuse ranks 10th among FBS teams for time of possession per game this season (33:51).

Syracuse Orange vs. Virginia Cavaliers Prediction

I’m on the under here. This for me is just another game on Saturday’s card that I think will be affected by weather and even if it wasn’t, these are two teams I don’t trust offensively, especially at the QB position. and I think this is a spot where it’s just a lot of mucking around between the 20s in a low-scoring game. Give me the under.

Chris Ruffolo's Pick: Under 49.5