UConn vs DePaul Prediction 12/21/2025 Today’s College Basketball Picks

In this article, we will formulate a UConn vs DePaul Prediction for this College Basketball game on Sunday, December 21st. Let’s take a look at the prediction for this College Basketball matchup.

DePaul Blue Demons Preview

DePaul Blue Demons have an 8-4 record this season and are sitting in 8th place of the Big East. They have a 6-2 home record and are coming off a 79-66 away loss against St. John’s. Their previous three games were a 61-58 away win against Wichita State, a 92-49 home win against Morgan State, and a 76-72 home win against Arkansas-Pine Bluff.

Offensively, DePaul averages 76.4 points per game, while allowing 68.8 points per game defensively. The Blue Demons shoot with 45.4% from the field and grab 33.8 rebounds per game, while dishing out 17 assists per game. They average 3.3 blocks per game and 7.3 steals per game defensively.

CJ Gunn leads DePaul in scoring, with an average of 14.3 points per game, while shooting with 44.9% from the field and 78.9% from the free throw line. NJ Benson leads the team in rebounds with 6.5 per game, while Layden Blocker adds a team-high 3.8 assists per game.

UConn Huskies Preview

UConn Huskies have an 11-1 record this season and are sitting in 1st place of the Big East. They have a 1-0 home record and are coming off a 79-60 home win against Butler. Their previous three games were a 71-63 home win against Texas, a 77-73 home win against Florida, and an 83-59 home win against East Texas A&M.

Offensively, UConn averages 79 points per game, while allowing 61.7 points per game defensively. The Huskies shoot with 50% from the field and grab 36.3 rebounds per game, while dishing out 18.4 assists per game. They average 5.8 blocks per game and 7.3 steals per game defensively.

Solo Ball leads UConn in scoring, with an average of 15.4 points per game, while shooting with 42.6% from the field and 83.7% from the free throw line. Alex Karaban leads the team in rebounds with 5.3 per game, while Silas Demary Jr. adds a team-high 5.6 assists per game.

Connecticut Huskies @ DePaul Blue Demons Betting Trends: December 21, 2025

Why the DePaul Blue Demons will win

• DePaul has won each of its last four games at Wintrust Arena.
• DePaul has won the first half in four of its last five games at Wintrust Arena.

Why the Connecticut Huskies will win

• DePaul has lost each of its last 21 games against AP-ranked opponents.
• Connecticut has won each of its last 11 December games as an AP-ranked team.
• Connecticut has won the first half in each of its last eight games against non-AP-ranked opponents.

Total Points Facts

• Each of DePaul’s last nine games against Conference opponents have produced a total of 138+ points.
• Each of Connecticut’s last eight Sunday games against Conference opponents have produced a total of 142+ points.

UConn vs DePaul Prediction

In this UConn vs DePaul Prediction, UConn is coming as -14.5 road favorites. UConn has been the better team this season, as they have lost only once in their 12 games this season and have won their only road game so far. They are playing against a DePaul squad that is 6-2 in its last 8 games and 3-0 against the spread in their last 3, but they have been inferior both on the offensive and the defensive end. UConn is a top-50 team in the nation both offensively and defensively, with a +17.3 point differential this season and I expect them to get the job done on the road today. Take UConn and lay the points.

Nikos Lagouretos's Pick: UConn -14.5