South Carolina vs Clemson Prediction 12/16/2025 Today’s College Basketball Picks

The South Carolina Gamecocks and the Clemson Tigers meet Tuesday in college basketball action from the Littlejohn Coliseum. We will look at this from a betting perspective and determine the best bets for this game. Here’s a South Carolina Gamecocks vs. Clemson Tigers prediction.

South Carolina Gamecocks Recap

The South Carolina Gamecocks come into this game looking to add on to their 71-55 win over the Citadel last time out to sit at 7-3 this season. After this game, South Carolina will head home for a game against South Carolina State.

Gamecocks Win Back-To-Back Games

Meechie Johnson leads the Gamecocks in scoring and assists with 15.5 PPG and 3.4 APG while Eli Ellis has 10.2 PPG with 2.9 RPG and 2.7 APG of his own this season. Mike Sharavjamts has 11.6 PPG with a team-high 6.6 RPG and Elijah Strong has 10.1 PPG to cap off the group of double-digit scorers for South Carolina so far this season. Kobe Knox has 9.3 PPG with 2.8 APG this season. As a team, South Carolina is averaging 80.1 PPG on 45.7% shooting from the field, 31.3% from three and 76.9% from the foul line this season.

Clemson Tigers Recap

The Clemson Tigers come into this game looking to add on to their 70-63 win over Mercer last time out to sit at 8-3 this season. After this game, Clemson will take on Cincinnati at home.

Tigers Snap Two-Game Slide

RJ Godfrey leads the Tigers in scoring and rebounding with 12.1 PPG and 6.4 RPG along with 2.3 APG while Carter Welling has 10.6 PPG with 6.2 RPG this season. Jestin Porter has 10.2 PPG with 2.1 RPG to cap off the trio of double-digit scorers for Clemson so far this season. Dillon Hunter has 9.2 PPG with 3.6 RPG and 2.7 APG while Nick Davidson has 8 PPG with 4.9 RPG and Jake Wahlin has 8 PPG with 4.8 RPG as well this season. Zac Foster’s added 7.8 PPG with 2.9 RPG and 2.9 APG as well to lead the Tigers in assists so far this season. As a team, Clemson is averaging 85.1 PPG on 46.3% shooting from the field, 32.8% from three and 74.9% from the foul line this season.

South Carolina Gamecocks @ Clemson Tigers Betting Trends: December 16, 2025

Why the Clemson Tigers will win

• Clemson has won each of its last 16 night games against non-Conference opponents at Littlejohn Coliseum.
• South Carolina has lost each of its last three games at Littlejohn Coliseum following a home win.
• Clemson has won the first half in each of its last 13 night games against non-Conference opponents at Littlejohn Coliseum.

Why the South Carolina Gamecocks will win

• South Carolina has won nine of its last 10 night games against non-Conference opponents.
• Clemson has lost three of its last four night games against the Southeastern Conference.
• South Carolina has won the first half in 25 of its last 27 night games against non-Conference opponents.

Total Points Facts

• Each of South Carolina’s last six road games against the Atlantic Coast Conference have produced a total of 139 or fewer points.
• Four of Clemson’s last five games against the Southeastern Conference have produced a total of 171+ points.

Matchup/League Facts

• Clemson ranks 6th among Division 1 teams for turnover percentage this season (11.3%).
• Clemson ranks T8th among Division 1 teams for turnovers per game this season (9.1).
• South Carolina ranks 2nd among Division 1 teams for opponent three-point field goals made per game this season (4.7).
• South Carolina ranks 7th among Division 1 teams for opponent three-point percentage this season (25.8%).

South Carolina Gamecocks vs. Clemson Tigers Prediction

I’m on South Carolina and the points here. This is just too many points for a rivalry game, and this historically has been a tight and competitive matchup. Clemson’s played a lot of teams close in step up spots this year, and I think that South Carolina can add themselves to that list here. Give me South Carolina and the points.

Chris Ruffolo's Pick: South Carolina +12.5