Louisville Cardinals guard Ryan Conwell (3) drove to the basket during the second half as the Louisville Cardinals hosted the Kentucky Wildcats at the KFC Yum! Center on Tuesday, Nov. 11, 2025. The Cardinals defeated the Wildcats 96-88.
Jeff Faughender/Courier Journal / USA TODAY NETWORK via Imagn Images

Ohio vs Louisville Prediction 11/15/2025 Today’s College Basketball Picks

Pick details

MATCHUP Ohio Bobcats Louisville Cardinals
Team Records 1-2 3-0
Spread +31.5 -105 -31.5 -115
Moneyline +5000 -100000
Total Over 175.5 (-110) Under 175.5 (-110)
Where KFC Yum! Center, Louisville, KY
When Saturday, November 15, 2025
Time 12:00 PM EST
TV The CW Network

In this article we will formulate an Ohio vs Louisville prediction for this College Basketball game on Saturday, November 15th at the KFC Yum! Center in Louisville, Kentucky. Let’s take a look at the prediction for this College Basketball matchup.

Ohio Bobcats Betting Preview

The Ohio Bobcats are 1-2 this season after they lost to St. Mary’s by a score of 90-60 in their last game. Ohio trailed 45-27 at halftime and allowed 45 more points in the second half in the loss. The Bobcats shot 38% from the field, 25% on three pointers, and 86% on free throws in the game. Ohio was out rebounded by a total of 40-29, recorded 12 assists, and committed 14 turnovers in the loss. Jackson Paveletzke led Ohio with 19 points and four assists, while Javan Simmons added 12 points and three rebounds in the game. 

Prior to that game, Ohio defeated Illinois State by a score of 72-68, but lost to Arkansas State by a score of 89-85 before that. The Bobcats have scored 72.3 points per game with 29.7 rebounds and 12.0 assists per game, while they have allowed 82.3 points against per game this season. Jackson Paveletzke is averaging 18.0 points and 4.0 assists per game, while Aidan Hadaway is averaging 15.3 points and 5.7 rebounds per game for the Bobcats. Ohio is shooting 45.6% from the field, 64.3% on free throws, and 25.9% on three pointers this season. 

Louisville Cardinals Betting Preview

The Louisville Cardinals are 3-0 this year after they defeated Kentucky by a score of 96-88 in their last game. Louisville led 53-46 at halftime and added 43 points in the second half to escape with the win. The Cardinals shot 45% from the field, 32% on three pointers, and 68% on free throws in the game. Louisville was out rebounded by a total of 42-40, recorded 20 assists, and committed six turnovers in the win. Mikel Brown Jr led Louisville with 29 points and five assists, while Ryan Conwell added 24 points and two assists in the game. 

Prior to that game, Louisville defeated Jackson State by a score of 106-70 and South Carolina State by a score of 104-45. The Cardinals have scored 102.0 points per game with 22.3 assists and 45.3 rebounds per game, while they have allowed 67.7 points against per game this season. Mikel Brown Jr is averaging 19.3 points and 6.7 assists per game, while Ryan Conwell is averaging 18.3 points and 4.0 rebounds per game for the Cardinals. Louisville is shooting 50% from the field, 73.7% on free throws, and 33.3% on three pointers this year. 

Why the Louisville Cardinals will win

  • Louisville has won each of its last 14 games at KFC Yum! Center.
  • Ohio has lost five of its last six games.

Total Points Facts

  • Each of Louisville’s last 44 day games at KFC Yum! Center have produced a total of 174 or fewer points.
  • Eighty-five of Ohio’s last 87 day games have produced a total of 175 or fewer points.

Ohio vs Louisville Prediction 

Louisville comes into this matchup after getting a great win over Kentucky last time out and they are 3-0 to start the year. The Cardinals are shooting 50% from the field and they have scored at least 96 points in all three wins. Ohio just lost by 30 points to St Mary’s and they also allowed 89 points to Arkansas State in their first game. Louisville should roll to an easy win here, but I feel like this is a spot they may struggle to keep focus. Take the points with Ohio.

David Racey's Pick: Ohio +31.5

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