LSU vs DePaul Prediction 11/29/2025 Today’s College Basketball Picks

The Depaul Blue Demons and the LSU Tigers meet Saturday in college basketball action from the Raider Arena. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Depaul Blue Demons vs. LSU Tigers prediction.

Depaul Blue Demons Recap

The Depaul Blue Demons come into this game looking to add on to their 75-61 win over Georgia Tech last time out to sit at 5-2 this season. 

Blue Demons Win 3 In A Row

CJ Gunn leads the Blue Demons in scoring with 14.6 PPG along with 3.3 RPG while Layden Blocker has 12.9 PPG with 2.6 RPG and a team-high 4.1 RPG to lead the Blue Demons in assists. NJ Benson has 10.7 PPG with a team-high 7.6 RPG to lead the Blue Demons in rebounding up to this point in the year. Kaleb Banks also has 8.1 PPG with 2.3 RPG and Brandon Maclin has 7.7 PPG with 4.6 RPG and 3 APG as well this season. As a team, Depaul is averaging 79.9 PPG on 45.6% shooting from the field, 34.3% from three and 71% from the foul line this season.

LSU Tigers Recap

The LSU Tigers come into this game looking to add on to their 71-62 win over Drake last time out to sit at 6-0 this season. 

Tigers Looking To Stay Unbeaten

Mike Nwoko leads the Tigers in scoring with 18.2 PPG and 5.8 RPG while Dedan Thomas Jr. has 14.8 PPG with 3.3 RPG and a team-high 7.3 APG to lead the Tigers in assists. Marquel Sutton has 13.3 PPG with 9 RPG to lead the Tigers in rebounding and Max Mackinnon has 13 PPG with 2.7 RPG and 3.2 APG to cap off the group of double-digit scorers for LSU so far this season. Jalen Reed also has 9.5 PPG with 5.7 RPG and Robert Miller III has 6.3 PPG with 3.5 RPG as well this season. As a team, LSU is averaging 52.9 PPG on 35.8% shooting from the field, 35.8% from three and 77.3% from the foul line this season.

LSU Tigers @ DePaul Blue Demons Betting Trends: November 29, 2025

Why the DePaul Blue Demons will win

• DePaul has won each of its last three games.
• LSU has lost 10 of its last 11 Saturday games.
• LSU has lost the first half in each of its last five games against the Big East Conference.

Why the LSU Tigers will win

• LSU has won each of its last 13 night games against non-Conference opponents.
• DePaul has lost each of its last nine Saturday night games.
• LSU has won the first half in each of its last 11 games against non-Conference opponents.

Matchup/League Facts

• DePaul ranks 17th among Division 1 teams for opponent three-point field goal attempts per game this season (18.3).
• DePaul ranks T36th among Division 1 teams for assists per game this season (18.3).
• LSU ranks 4th among Division 1 teams for opponent free throw percentage this season (61.9%).
• LSU ranks 6th among Division 1 teams for free throws made per game this season (22.7).

Depaul Blue Demons vs. LSU Tigers Prediction

I’m backing Depaul and the points here. I just think that the Blue Demons are competitive early on this season, and have been competitive the lone times they’ve had small lines or have been an underdog. LSU is solid, but they’ve failed to cover in three of their last four as decent-sized favorites and I think Depaul can cover this one. Give me the Blue Demons.

Chris Ruffolo's Pick: Depaul ATS