Louisville vs Indiana Prediction 12/6/2025 Today’s College Basketball Picks

The Louisville Cardinals and the Indiana Hoosiers meet Saturday in college basketball action from the Gainbridge Fieldhouse. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Louisville Cardinals vs. Indiana Hoosiers prediction.

Louisville Cardinals Recap

The Louisville Cardinals come into this game looking to rebound from an 89-80 loss at the hands of Arkansas last time out to sit at 7-1 on the year. After this game, Louisville will head home for a game against Memphis.

Cardinals Suffer First L

Ryan Conwell leads the Cardinals in scoring with 19.5 PPG along with 4.9 RPG and 2.6 APG while Mikel Brown Jr. has 17.6 PPG with a team-high 5.6 APG to lead the Cardinals in assists and 3.5 RPG. Isaac McKneely’s added 12.1 PPG with 3.6 RPG and Sananda Fru has 10.4 PPG with 6.1 RPG to lead the Cardinals in rebounding and to round out the group of double-digit scorers for Louisville so far this season. J’Vonne Hadley has 9 PPG with 5.7 RPG while Adrian Wooley’s added 8.6 PPG with 4.5 RPG and Khani Rooths has 7 PPG with 5 RPG this season. As a team, Louisville is averaging 94.6 PPG on 47.2% shooting from the field, 35.3% from three and 76% from the foul line this season.

Indiana Hoosiers Recap

The Indiana Hoosiers come into this game looking to bounce back from a 73-64 loss at the hands of Minnesota in their last game to sit at 7-1 on the year. After this game, Indiana will take on Penn State at home.

Hoosiers Have 7-Game Win Streak Snapped

Tucker DeVries leads the Hoosiers in scoring with 16.8 PPG along with 5.1 RPG and 3.4 APG while Lamar Wilkerson has 16.5 PPG with 2.6 RPG and 2.3 APG. Tayton Conerway has 12.6 PPG with a team-high 4.9 APG to lead the Hoosiers in assists along with 3.3 RPG while Reed Bailey has 10.6 PPG with 4.1 RPG and Sam Alexis has 10.5 PPG with a team-high 6 RPG to lead the Hoosiers in rebounding and to round out the group of double-digit scorers for the Hoosiers up to this point in the year. Trent Sisley also has 8.8 PPG with 4.9 RPG as well on the year.

Louisville Cardinals @ Indiana Hoosiers Betting Trends: December 6, 2025

Why the Indiana Hoosiers will win

• Indiana has won each of its last 12 games against non-Conference opponents.
• Louisville has lost 16 of its last 17 day games against AP-ranked opponents.
• Indiana has won the first half in each of its last 12 games against non-Conference opponents.

Why the Louisville Cardinals will win

• Indiana has lost each of its last seven games against AP-ranked opponents at a neutral venue.
• Louisville has won 28 of its last 32 games.
• Indiana has lost the first half in 14 of its last 15 games against AP-ranked opponents at a neutral venue.

Total Points Facts

• Forty-four of Louisville’s last 46 day games against AP-ranked opponents have produced a total of 158 or fewer points.
• Each of Indiana’s last nine day games against the Atlantic Coast Conference have produced a total of 157 or fewer points.

Louisville Cardinals vs. Indiana Hoosiers Prediction

I’m on Indiana and the points here. I just think that Indiana is a team I’m not looking to pass up points with, as this is a bit of a home game for the Hoosiers with this game being played in Indianapolis, and I think this is a game that could come down to the wire if the Hoosiers don’t win this game outright. Give me the Cardinals and the points here.

Chris Ruffolo's Pick: Indiana +4.5