Lipscomb vs Duke Prediction 12/16/2025 Today’s College Basketball Picks

In this article we will formulate a Lipscomb vs Duke prediction for this College Basketball game on Tuesday, December 16th at Cameron Indoor Stadium in Durham, North Carolina. Let’s take a look at the prediction for this College Basketball matchup.

Lipscomb Bisons Betting Preview

The Lipscomb Bisons are 6-4 this season after they defeated Alabama A&M by a score of 92-58 in their last game. Lipscomb led 35-28 at halftime and added 57 points in the second half for the blowout win. The Bisons shot 60% from the field, 38% on three pointers, and 62% on free throws in the game. Kennedy Okpara led Lipscomb with 17 points and three rebounds, while Grant Asman added 15 points and eight rebounds in the win. 

Prior to that game, Lipscomb defeated Tennessee Tech by a score of 83-80 and SEMO by a score of 88-77. The Bisons have scored 80.4 points per game with 36.6 rebounds and 19.0 assists per game, while they have allowed 73.8 points against per game this season. Grant Asman is averaging 13.7 points and 6.4 rebounds per game, while Ross Candelino is averaging 11.8 points and 5.4 rebounds per game for the Bisons. Lipscomb is shooting 44.4% from the field, 75.5% on free throws, and 34.5% on three pointers this season. 

Duke Blue Devils Betting Preview

The Duke Blue Devils are 10-0 this year after they defeated Michigan State by a score of 66-60 in their last game. Duke trailed 34-31 at halftime, but held MSU to just 26 points in the second half in the comeback win. The Blue Devils shot 38% from the field, 31% on three pointers, and 65% on free throws in the game. Cameron Boozer led Duke with 18 points and 15 rebounds, while Caleb Foster added 12 points and four rebounds in the win. 

Prior to that game, Duke defeated Florida by a score of 67-66 and Arkansas by a score of 80-71. The Blue Devils have scored 86.8 points per game with 42.2 rebounds and 18.7 assists per game, while they have allowed 59.6 points against per game this season. Cameron Boozer is averaging 23.0 points and 9.9 rebounds per game, while Isaiah Evans is averaging 12.2 points and 3.3 rebounds per game for the Blue Devils. Duke is shooting 50% from the field, 71.0% on free throws, and 35.5% on three pointers this year. 

Why the Duke Blue Devils will win

• Duke has won each of its last 22 games at Cameron Indoor Stadium.
• Lipscomb has lost each of its last four night games against non-Conference opponents.
• Lipscomb has lost the first half in each of its last four road night games against non-Conference opponents.

Why the Lipscomb Bisons will win

• Lipscomb has won each of its last five games against non-Conference opponents.

Lipscomb vs Duke Prediction 

Duke comes into this matchup trying to keep their undefeated record alive and they should have no issues winning this game. The Blue Devils are coming off of three ranked wins against Michigan State, Florida, and Arkansas, and they are shooting 50% from the field. Lipscomb has won five games in a row and they have scored at least 83 in all five. The Bisons are shooting just 44% from the field and they already have a 44 point loss to Vanderbilt on the season. I don’t love this number, but I think this is Duke or pass for me.

David Racey's Pick: Duke -33.5