Jackson State vs Louisville Prediction 11/6/2025 Today’s College Basketball Picks

In this article, we will formulate a Jackson State vs Louisville Prediction for this College Basketball game on Thursday, November 6th. Let’s take a look at the prediction for this College Basketball matchup.

Louisville Cardinals Preview

The Louisville Cardinals have a 1-0 record this season and are 1-0 ATS and 0-1 in Over/Under. They are coming off a 104-45 win at home against South Carolina State. The Cardinals shot 54.8% from the field and 44.4% from beyond the arc. They made 76.5% of their free throws and grabbed 46 rebounds, while dishing out 22 assists and committing 11 turnovers. They had 20 fast break points and 44 points in the paint.

Sananda Fru, Ryan Conwell, Mikel Brown Jr., Isaac McKneely and J’Vonne Hadley were the starting five for Louisville, with McKneely being the top scorer with 17 points and 4 rebounds, while shooting 46.2% from the field. J’Vonne Hadley followed with 13 points and 9 rebounds, while shooting 71.4% from the field. Ryan Conwell added 12 points and 3 rebounds.

Jackson State Tigers Preview

The Jackson State Tigers have a 0-1 record this season and are 0-1 ATS and 1-0 in Over/Under. They are coming off a 55-113 loss on the road against Illinois. The Tigers shot 30.6% from the field and 24.1% from beyond the arc. They made 71.4% of their free throws and grabbed 19 rebounds, while dishing out 5 assists and committing 11 turnovers. They had 17 fast break points and 20 points in the paint.

Kobe Butler, Devin Ree, Dorian McMillian, Jayme Mitchell Jr. and Daeshun Ruffin were the starting five for Jackson State, with Ree being the top scorer with 19 points and 1 rebound, while shooting 63.6% from the field. Daeshun Ruffin followed with 12 points and 5 rebounds, while shooting 45.5% from the field. Jayme Mitchell Jr. added 7 points and one rebound.

Jackson State Tigers @ Louisville Cardinals Betting Trends: November 6, 2025

Why the Louisville Cardinals will win

• Jackson State has lost each of its last 16 games against non-Conference opponents.
• Louisville has won each of its last 15 games at KFC Yum! Center against non-AP-ranked opponents.
• Louisville has won the first half in each of its last 11 games at KFC Yum! Center.

Why the Jackson State Tigers will win

• Jackson State has won each of its last four games following a road loss.
• Jackson State has won the first half in six of its last seven night games.

Total Points Facts

• Each of Louisville’s last 11 night games have produced a total of 157 or fewer points.
• Each of Jackson State’s last 12 Thursday games against non-Conference opponents have produced a total of 151 or fewer points.

Matchup/League Facts

• Louisville ranks T2nd for field goals attempted per game (70.0) in last season’s NCAA Tournament.
• Louisville ranks T2nd for turnovers per game (6.0) in last season’s NCAA Tournament.

Jackson State vs Louisville Prediction

Louisville has won both meetings against Jackson State, both at home, by 62-45 and 84-53. In this Jackson State vs Louisville Prediction, Louisville is coming as -34.5 home favorites. Louisville was the superior team last season and they started the new season on the right foot, with a dominating 59-point win against South Carolina State. On the flip side, Jackson State is coming off a brutal 58-point road defeat to Illinois and last season’s defensive woes seems to be continuing this year as well. Louisville is by far the better team in this matchup and I expect a comfortable win in this one. Take Louisville and lay the points at home.

Nikos Lagouretos's Pick: Louisville -34.5